Whether inflammation leaves a lasting imprint on the intestinal stem cell (ISC) niche has remained unknown. Adir et al. find that persistent modified ECM (modECM) encodes inflammatory memory, reshapes Lgr5+ ISCs into wound-associated epithelia, and pro…
Mechanisms governing T cell responses to food or microbes have been characterized; however, whether they also regulate gut autoimmunity is unknown. Zhou et al. uncover that self-antigens depend on distinct subsets of antigen-presenting cells compared w…
Cytokine cues reshape how chromatin folds to control immune gene activity. Jay et al. show that cytokine signals reposition the Ets1 super-enhancer toward the geometric center of the locus and sustain Ets1 expression required for helper T cell differen…
The role of noncoding lncRNAs in human disease is difficult to ascertain. Yang-Fischer et al. identify lnc15 (2310015A10Rik/ENSMUSG00000097729) as a cytoplasmic brake on intestinal inflammation. lnc15 expression is decreased in active human inflammator…
Ginhoux and colleagues review the mechanisms underlying the impact of obesity on cancer susceptibility, progression, and response to therapy. They discuss how metabolic stress reprograms myeloid cells, particularly macrophages, driving chronic inflamma…
The intestinal barrier harbors numerous intraepithelial lymphocytes (IELs) that promote tissue integrity and whose dysfunction contributes to disease. Earley et al. studied the G-protein coupled receptor signals regulating IEL movement and function and…
Recent studies have expanded the field of autophagy in immunity to include related but incompletely understood noncanonical autophagy processes. Deretic reviews these advancements in the context of immunity, offering a unifying framework for canonical …
(Immunity 25, 237–247; August 2006)
UVR-damaged melanocytes evade immune attack despite harboring many mutations. Lo et al. show that MITF, a transcriptional regulator crucial to melanocyte identity, directly induces the immune checkpoint molecule PD-L1. This intrinsic tolerance program …
Generating mice that express human antibodies is a lengthy and labor-intensive process. Knocking in human gene segments into mice has potential, but how large a gene segment can be knocked into a zygote? Nair et al. insert a 155-kb human VH locus direc…
