Trends in Immunology

Trends Immunol. 2026 Aug 5:S1471-4906(26)00183-3. doi: 10.1016/j.it.2026.07.004. Online ahead of print. ABSTRACT Emerging evidence now points to innate tissue immunity as a critical orchestrator of both local tissue adaptation and long-range hematopoietic reprogramming, including the amplification of emergency granulopoiesis through bone marrow progenitor remodeling. These findings position the intestine as an instructive niche capable of … Read more

Trends Immunol. 2026 Aug 1:S1471-4906(26)00184-5. doi: 10.1016/j.it.2026.07.005. Online ahead of print. NO ABSTRACT PMID:42542412 | DOI:10.1016/j.it.2026.07.005

Trends Immunol. 2026 Aug 1:S1471-4906(26)00187-0. doi: 10.1016/j.it.2026.07.008. Online ahead of print. ABSTRACT Spatial multi-omics of aging human lymph nodes by Fan and colleagues reveals that immunosenescence manifests as focal B cell coalescence into ‘SenSpots’ within germinal centers, where concerted epigenetic, transcriptional, proteomic, and metabolic reprogramming spatially orchestrates the decline of humoral immunity. PMID:42538165 | DOI:10.1016/j.it.2026.07.008

Trends Immunol. 2026 Jul 31:S1471-4906(26)00181-X. doi: 10.1016/j.it.2026.07.002. Online ahead of print. ABSTRACT CD8+ T cell exhaustion is increasingly recognized as a regulated adaptation to chronic antigenic stimulation rather than a simple immune failure. Indeed, recent studies reveal that exhaustion is imprinted early after T cell activation, integrating transcriptional and epigenetic cues to balance effector function … Read more

Trends Immunol. 2026 Jul 30:S1471-4906(26)00182-1. doi: 10.1016/j.it.2026.07.003. Online ahead of print. ABSTRACT Homing pigeons’ navigation in darkness relies on Earth’s magnetic field. However, the underlying mechanism of magnetoreception remains poorly understood. Recently, Lisowski et al. demonstrated that superparamagnetic hepatic macrophages are potential magnetoreceptors that detect and transmit geomagnetic information to support the navigation of pigeons. … Read more

Trends Immunol. 2026 Jul 29:S1471-4906(26)00180-8. doi: 10.1016/j.it.2026.07.001. Online ahead of print. NO ABSTRACT PMID:42527288 | DOI:10.1016/j.it.2026.07.001

Trends Immunol. 2026 Jul 15:S1471-4906(26)00164-X. doi: 10.1016/j.it.2026.06.008. Online ahead of print. ABSTRACT More than 4 decades after the discovery of MHC restriction, it is clear that the phagocytosis of dying cells is not the only route by which macrophages acquire antigens. Fan and colleagues further expand this paradigm by showing that macrophages can sample a … Read more

Trends Immunol. 2026 Jul 16:S1471-4906(26)00165-1. doi: 10.1016/j.it.2026.06.009. Online ahead of print. ABSTRACT Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies, characterized by a highly complex and dynamic tumor microenvironment in which tumor-associated macrophages (TAMs) are particularly abundant. TAMs regulate tumor initiation, progression, metastasis, and therapy response, making them attractive targets. However, targeting TAMs … Read more

Trends Immunol. 2026 Jul 14:S1471-4906(26)00163-8. doi: 10.1016/j.it.2026.06.007. Online ahead of print. ABSTRACT Macrophages are central regulators of immunity, tissue homeostasis, and repair, whose plasticity enables them to integrate cues from their local microenvironment. Dysregulated macrophages contribute to chronic inflammation, fibrosis, impaired wound healing, and tumor progression. Biomaterials enable the modulation of macrophages through localized delivery … Read more

Trends Immunol. 2026 Jul 8:S1471-4906(26)00161-4. doi: 10.1016/j.it.2026.06.005. Online ahead of print. ABSTRACT CD8+ T cell dysfunction, characterized by impaired effector function, proliferative capacity, and sustained inhibitory receptor expression, limits immune control in both cancer and chronic viral infections. Despite arising from distinct disease processes, these conditions induce a shared state of CD8+ T cell dysfunction, … Read more