Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are established components of endocrine therapy for hormone receptor-positive (HR+), HER2-negative breast cancer. Beyond RB-dependent G1 arrest, these drugs alter antigen presentation, interferon sign…
BackgroundMitochondria transfer is an emerging mechanism of intercellular communication involved in mitochondrial homeostasis, metabolic remodeling, immune regulation, inflammatory responses, tumor progression, and mitochondrial transplantation-based t…
BackgroundImmune checkpoint inhibitor (ICI)-related cardiovascular toxicity is associated with high mortality, and prediction models may facilitate its prevention and management. However, the predictive performance, quality, risk of bias, and applicabi…
IntroductionAntibody–drug conjugates (ADCs) have established roles in selected lymphoma settings, but the maturity, subtype distribution, and platform diversity of the clinical pipeline remain unclear. We mapped interventional trials to evaluate develo…
BackgroundTalquetamab, a first-in-class G protein–coupled receptor family C group 5 member D (GPRC5D) × CD3 bispecific antibody, demonstrates substantial clinical activity in relapsed/refractory multiple myeloma (RRMM). However, immune dysfunction asso…
IntroductionPembrolizumab, an immune checkpoint inhibitor (ICI) targeting programmed cell death protein 1 (PD-1), has demonstrated significant clinical value in the treatment of human epidermal growth factor receptor 2 (HER2)-negative advanced gastric …
BackgroundPreeclampsia is a pregnancy disorder endangering maternal and fetal health, often accompanied by complications such as hypertension and proteinuria. Natural killer cells are indispensable in the occurrence and development of preeclampsia. Up …
BackgroundTumor-associated macrophages (TAMs) play a critical role in lung cancer progression, immune evasion, and treatment resistance within the unique, tissue-specific pulmonary immune microenvironment. However, a comprehensive bibliometric synthesi…
BackgroundWhile immune checkpoint inhibitors (ICIs) have revolutionized first-line treatment for advanced gastric and gastroesophageal junction (GEJ) adenocarcinoma, outcomes across phase III trials remained heterogeneous. This study aimed to determine…
BackgroundKrabbe disease is a rare, rapidly progressive leukodystrophy with high early mortality. Hematopoietic stem cell transplantation (HSCT) is the main disease-modifying intervention used in clinical practice and may act through donor-derived myel…
