BackgroundCommunity residents with chronic diseases face a higher risk of falls, functional decline, and loss of independence, constituting a significant public health burden. Exercise therapy is widely recommended; however, its efficacy in improving b…
IntroductionHighly sensitized candidates, preformed donor-specific antibodies, and ABO incompatibility restrict access to kidney transplantation and increase antibody-mediated rejection (AMR) risk. We systematically evaluated peri-transplant eculizumab…
BackgroundThe efficacy of adding PD-1/PD-L1 inhibitors to chemotherapy ± bevacizumab in recurrent or metastatic cervical cancer is under active investigation.ObjectiveTo systematically evaluate the efficacy and safety of PD-1/PD-L1 inhibitors combined …
BackgroundUlcerative colitis (UC) reduces the quality of life for patients and creates a significant economic burden on global healthcare systems. Although there have been advances in UC clinical trials recently, most existing reviews have primarily fo…
BackgroundThe intestinal mycobiome is increasingly recognized as an important component of host–microbiota interactions in inflammatory bowel disease (IBD), yet its contribution to intestinal immune dysregulation remains incompletely characterized. We …
Yellow fever (YF) 17D-lineage vaccines are among the most effective vaccines ever developed, providing long-term protection traditionally attributed to neutralizing antibodies. However, growing evidence suggests that cellular immunity also contributes …
The trematodes Fasciola hepatica and Fasciola gigantica exhibit a broad host range, infecting various mammalian species, including sheep, cattle, and, sporadically, humans. In cattle, fasciolosis constitutes a significant economic concern, often result…
BackgroundInterleukin-33 (IL-33) is an epithelial-derived member of the IL-1 cytokine family that functions as an alarmin and signals through the ST2 receptor, upstream of type 2 inflammation. Together with thymic stromal lymphopoietin (TSLP) and IL-25…
BackgroundExercise, physical activity, and physical fitness are increasingly discussed in psoriasis and psoriatic arthritis (PsA), but the evidence base is uneven: intervention reviews predominantly concern PsA, whereas evidence for cutaneous psoriasis…
BackgroundAnti-melanoma differentiation-associated protein 5 antibody-positive dermatomyositis (anti-MDA5+ DM) spans pulmonary states from no detectable interstitial lung disease (ILD) to rapidly progressive ILD (RP-ILD). We mapped molecular programs a…
