BackgroundPrimary Sjögren’s syndrome (pSS) is epidemiologically associated with an increased risk of Alzheimer’s disease (AD); however, the shared IFN-γ-related immune mechanisms underlying this association remain poorly understood.MethodsPeripheral bl…
BackgroundImmune regulatory networks contribute to colorectal cancer (CRC) progression, but most clinical studies focus on tissue immune-cell abundance or static inflammatory mediators. We investigated cytokine-response patterns in cultures derived fro…
BackgroundBone destruction constitutes the primary cause of disability in rheumatoid arthritis (RA). Herbal medicines feature unique multi-target advantages, rendering them promising therapeutic candidates for attenuating RA-associated bone damage.Obje…
BackgroundPrimary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by thrombocytopenia, and approximately 20-30% of patients are refractory to or dependent on first-line glucocorticoid therapy. Our previous prospective phase II stu…
Lupus mesenteric vasculitis (LMV) is a gastrointestinal lesion primarily caused by vasculitis associated with systemic lupus erythematosus (SLE). In our preliminary experiments, we found that NZBWF1 (BWF1) mice, a spontaneous SLE mouse model, developed…
Aging is a major contributor to the decline in egg quality, with uterine inflammaging playing a key role in this process. Implementing anti-aging strategies to prevent uterine inflammaging and sustain optimal eggshell quality is imperative. This study …
IntroductionChildren with latent tuberculosis (LTBI) infection are more susceptible to Mycobacterium tuberculosis (Mtb) disease than adults with LTBI. HIV infection in children significantly enhances the development of LTBI into active TB due to the im…
ObjectiveThe neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and triglyceride-glucose (TyG) index are used to evaluate the risk of coronary artery disease (CAD) or chronic kidney disease (CKD). However, there are limited repor…
Sepsis frequently induces intestinal barrier injury, which exacerbates systemic inflammation, and contributes to high mortality. Group 3 innate lymphoid cells (ILC3s) are key regulators of mucosal immunity, yet their role in sepsis-associated intestina…
BackgroundThe complement system plays an important role in innate immunity and age-related inflammation, but its prognostic value in centenarians remains unclear. This study aimed to examine the associations between serum complement C3 and C4 levels an…
