BackgroundNon-starch polysaccharides (NSPs) support gut health at low levels but may impair nutrient absorption and trigger inflammation when consumed excessively. Pomegranate peel powder (PPP), rich in punicalagin, ellagic acid, gallic acid, and querc…
IntroductionBladder cancer remains a therapeutic challenge due to its high recurrence and metastasis rates. Cancer-associated fibroblasts (CAFs) are recognized as pivotal regulators of the tumor microenvironment (TME), however the specific contribution…
BackgroundImmunological non-responders (INRs) and immunological responders (IRs) exhibit distinct patterns of immune reconstitution despite suppressive antiretroviral therapy (ART); however, the genetic characteristics of the HIV-1 reservoir in these g…
ObjectiveTo elucidate the role and molecular mechanism of the NADPH oxidase key subunit p47phox in deep vein thrombosis (DVT) formation by investigating its regulatory effects on neutrophil extracellular traps (NETs) generation, the PAC-1/FNG/MAC-1 sig…
Age-associated B cells (ABCs) have emerged as a distinct B cell population associated with aging, chronic inflammation, and autoimmunity. Notably, the expansion of ABC-like CD11c-expressing B cells has been observed in patients with systemic lupus eryt…
Antigen 85B (Ag85B), an immunodominant protein secreted by Mycobacterium tuberculosis (Mtb), induces robust T-cell-mediated immunity in host cells. Previous studies have demonstrated that recombinant BCG strains overexpressing Ag85B (BCG85B) confer sig…
BackgroundRising antimicrobial resistance rates require new therapeutic approaches such as antimicrobial peptides (AMPs), which are part of the innate immune defense, as alternatives to antibiotics. In this study, we aim to unravel the antibacterial ac…
BackgroundKiller-cell immunoglobulin-like receptors (KIR) are highly polymorphic receptors expressed by natural killer (NK) cells that regulate immune responses through interactions with HLA class I ligands. Variation in KIR gene content influences imm…
IntroductionBurn injuries are a common and devastating trauma that induce profound alterations in the immune microenvironment and further influence patient recovery and clinical outcomes. This study aimed to characterize the immune landscape of burn pa…
BackgroundThe ongoing circulation of SARS-CoV-2 Omicron sublineages continues to threaten vulnerable populations such as individuals with diabetes mellitus. Diabetes is well documented to impair host immune function; however, the correlation between cl…
