The efficacy of immune checkpoint blockers in solid tumors remains limited by the physical and biological barriers posed by the tumor microenvironment, which restrict antibody transport and suppress anti-tumor immune responses. Focused ultrasound has e…
Macrophages are highly plastic immune cells derived from bone marrow progenitors that respond dynamically to environmental cues and coordinate inflammation, debris clearance, tissue remodeling, wound repair, and regeneration. Although traditionally cla…
Background and aimsHepatocellular carcinoma (HCC) has a spatially heterogeneous immune microenvironment, but the compartment-specific distribution of tumor-associated neutrophils (TANs) and its relationship with systemic inflammation remain incompletel…
BackgroundPediatric tuberculosis (TB) remains a diagnostic challenge due to atypical presentations and low pathogen detection rates. Overlapping clinical features with Mycoplasma pneumoniae (MP) infection further complicate differential diagnosis. Immu…
Antibody fusion proteins incorporating immunomodulatory molecules, such as cytokines of the common γ-chain receptor family and costimulatory members of the TNF superfamily, hold great potential for cancer immunotherapy, with many candidates already adv…
BackgroundKeloids are fibroproliferative skin disorders characterized by persistent extracellular matrix deposition and limited treatment options. Ferroptosis has been implicated in fibrosis, but the molecular basis of ferroptosis-related changes in ke…
Lentivirus (LV)-based manipulation of immune cells is a commonly used approach in cell therapies. However, the most frequently used Vesicular Stomatitis Virus Glycoprotein (VSV-G) pseudotyping approach is inefficient to support LV gene delivery of mous…
ObjectiveTo explore the role and underlying mechanism of mitochondrial transcription elongation factor TEFM in osteoarthritis (OA) cartilage degeneration.MethodsBioinformatics analysis based on the GSE114007 human knee cartilage dataset and two-sample …
BackgroundHyperkalemia occurs in liver transplant (LT) recipients due to calcineurin inhibitor initiation and post-operative renal dysfunction and is associated with significant patient morbidity and resource expenditures. Little is known about the pre…
Background and purposeIsolated seizures represent a distinct, rare, and underrecognized phenotype of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD). In recent years, documentation of this phenotype has been limited to spo…
