BackgroundCartilage injury is a hallmark of osteoarthritis (OA). erb-B2 receptor tyrosine kinase 2 (ERBB2) has been reported to be involved in mediating the therapeutic effects of polyphenols in orthopedic diseases. This study aimed to investigate the …
BackgroundChronically activated T-effector (Teff) cells can play a pivotal role in T-cell-mediated diseases including systemic lupus erythematosus subsets, lupus nephritis and graft-vs-host disease (GvHD). Since T cells require diverse costimulation si…
BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic inflammatory disease of the upper airway driven by diverse inflammatory cells and mediators. This study aimed to characterize the inflammatory landscape of CRSwNP and to identify …
BackgroundSequential conditioning allogeneic hematopoietic stem cell transplantation (allo-HSCT) regimens might offer improved disease control in high-risk myeloid patients. But concerns remain regarding toxicity, infection risk and delayed immune reco…
BackgroundTacrolimus is a core immunosuppressant in organ transplantation, but its narrow therapeutic window and significant pharmacokinetic variability hinder precision dosing. Although CYP3A5-guided strategies have established clinical relevance for …
BackgroundAcute gouty arthritis (AGA) is an acute inflammatory disorder triggered by the deposition of monosodium urate crystals (MSU) in the joints, clinically characterized by severe pain and transient limitation of joint mobility. Without proper int…
ObjectiveThrombocytopenia in APS is often regarded primarily as a bleeding-related manifestation, but the relationship between platelet-count severity and thrombotic manifestations remains uncertain. We evaluated the association between severe thromboc…
BackgroundOsteoporosis (OP) is a frequent comorbidity in rheumatoid arthritis (RA). This study compared the performance of RA disease-activity scores with complete blood count (CBC)-derived indices for identifying prevalent OP.MethodsWe retrospectively…
BackgroundTrigger finger (TF) is a common hand disorder traditionally viewed as a localized mechanical condition. Recent evidences suggests potential links between tenosynovial pathology and systemic inflammatory diseases, especially rheumatoid arthrit…
IntroductionTyrosine kinase inhibitors targeting the c-KIT receptor are pivotal in the targeted therapy of malignancies such as gastrointestinal stromal tumors (GIST). The bioactivity of these inhibitors is typically quantified by the half-maximal inhi…
