Salmonella is a major foodborne pathogen that causes approximately 1.35 million infections annually in the US and remains a leading cause of poultry-associated foodborne illness. To improve chickens’ resistance to this pathogen, it is important to unde…
BackgroundRadiation-induced intestinal injury denotes structural and functional impairment of the intestines resulting directly or indirectly from ionizing radiation, such as that employed in radiation therapy for malignant tumors in the abdominal or p…
BackgroundRituximab (RTX) represents an established therapeutic option for myasthenia gravis refractory to conventional immunotherapy. However, its heterogeneous efficacy across populations creates a challenge in clinical application, necessitating the…
Background and objectiveChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is common in young and middle-aged men, but existing animal models have key limitations. We aimed to establish a C57BL/6N mice model for mechanistic studies of CP/CPPS.M…
IntroductionCervical tuberculous lymphadenitis (CTL) represents a localized manifestation of Mycobacterium tuberculosis infection in which immune responses are organized within lymphoid tissue. While cytotoxic lymphocyte responses contribute to antimyc…
BackgroundDegenerative lumbar spine disorders (DLSD), including intervertebral disc disorders (IDD), degenerative spondylolisthesis, and lumbar spinal stenosis (LSS), are major contributors to low back pain and disability. Associations among gut microb…
BackgroundPediatric asthma (PA) is a prevalent chronic respiratory disease. Emerging evidence suggests that dysregulated macrophage heterogeneity and immune-metabolic crosstalk contribute to disease pathogenesis, yet specific molecular nodes linking in…
IntroductionPersistent immune activation and inflammation remain significant barriers to managing comorbidities in people living with HIV (PLWH) on suppressive antiretroviral therapy (ART). While ART substantially reduces plasma viral loads to an undet…
BackgroundJohne’s disease (JD), caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic enteric disease affecting cattle worldwide, with considerable economic implications for dairy producers. MAP is a robust, intracellular pathogen h…
PurposeTP53 mutations are among the strongest adverse prognostic factors in large B-cell lymphoma (LBCL) treated with chemoimmunotherapy. Whether this unfavorable prognostic impact persists in the era of chimeric antigen receptor (CAR) T-cell therapy r…
