BackgroundHepatocellular carcinoma (HCC) has a poor prognosis, and identifying key driver genes and their molecular mechanisms is crucial for improving patient outcomes. While TOP2A is dysregulated in multiple cancers, its role and regulatory network i…
BackgroundThe fatality rate of virulent rabies virus (RABV) following central nervous system (CNS) invasion is nearly 100%. Infection with the virulent CVS-11 strain is associated with severe neurological symptoms and lethal outcomes, while the attenua…
ObjectivesJanus kinase (JAK) inhibitors are approved for several immune-mediated inflammatory disorders (IMIDs), but regulatory agencies, including the European Medicines Agency and the US Food and Drug Administration, have issued class-wide safety war…
The microbiome is an important immune regulator, but the mechanisms by which commensal microbes shape systemic host defense during bloodstream infection remain poorly defined and commonly used pre-clinical models have practical, ethical and scientific …
BackgroundHouse dust mite (HDM) Blomia tropicalis is a major global inducer of allergic asthma, yet its epigenetic impact on airway tissues remains poorly understood. The aim of this study was to perform an exploratory, hypothesis-generating screening …
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited therapeutic options, in which neuroinflammation critically drives disease progression. Regulatory T cells (Tregs) exert potent immunosuppressive and neuroprotective e…
BackgroundThe rising global incidence of inflammatory bowel disease (IBD) creates an urgent need for safer, gut-targeted therapies. Current treatments, from small-molecule drugs to systemic anti-tumor necrosis factor-alpha (TNF-α) biologics, are freque…
BackgroundHuman dental pulp stem cells (hDPSCs) are a mesenchymal stromal cell (MSC)–like population with emerging therapeutic relevance, yet their immunomodulatory behavior remains incompletely defined.MethodsHere we examine how hDPSCs from three inde…
ObjectiveTo define the shared and divergent immune architecture of periodontitis (PD) and peri-implantitis (PI) and to identify intercellular communication programs linked to plasma cell accumulation.MethodsDifferentially expressed genes (DEGs) in PD a…
IntroductionKoi herpesvirus (KHV or CyHV-3) causes a highly contagious and lethal disease in common carp and koi, resulting in substantial economic losses in global aquaculture. Rapid point-of-care testing (POCT) of KHV is critical for curbing its spre…
