BackgroundNecrotizing enterocolitis (NEC) is a severe multifactorial inflammatory disorder of the preterm intestine for which effective preventive and therapeutic strategies remain limited. Using formula feeding (FF)-associated dysbiosis combined with …
IntroductionAeromonas hydrophila is a major pathogen of bacterial enteritis in aquaculture and a pathogen threatening the safety of fish products; sustainable alternatives to antibiotics are urgently needed. This study explored the potential effects of…
ObjectiveThis retrospective cohort study enrolled 20,538 middle-aged and older patients with acute ischemic stroke (AIS) to identify immune-metabolic clinical subtypes by unsupervised clustering, to examine the differential association between subtype …
IntroductionSepsis-induced intestinal epithelial barrier dysfunction contributes to gastrointestinal injury during critical illness, yet the molecular mechanisms underlying barrier disruption remain incompletely understood. This study investigated the …
BackgroundFatigue and depression are among the most prevalent and disabling symptoms in multiple sclerosis (MS) and are frequently reported to be strongly associated. This association is often interpreted as reflecting shared pathophysiology. However, …
IntroductionTo investigate the association between gut-airway microbiota dysbiosis, serum queuine levels, and early malignant transformation in patients with chronic obstructive pulmonary disease (COPD). We further explored whether the potential mechan…
Glioblastoma (GBM) is a highly malignant tumor with poor prognosis and limited effective treatment options. Emerging studies have suggested that gut microbiota may influence glioma progression through the gut-brain axis, though the precise mechanisms r…
BackgroundBulky tumor (T ≥ 50 mm) significantly compromises treatment outcomes in advanced non-small cell lung cancer (NSCLC) due to excessive tumor burden. Bronchial arterial chemoembolization (BACE) serves as an effective local intervention for reduc…
ObjectivesTo evaluate inflammatory-nutritional indices in relation to breast cancer (BC) risk and mortality and develop a cross-ethnically validated prediction model.MethodsFrom National Health and Nutrition Examination Survey (NHANES) 2005–2018, 485 B…
Persistent immune activation and inflammation contribute to non–AIDS comorbidities in people living with HIV (PLWH) despite long-term virological suppression. Given the central role of the gut in immune homeostasis, we investigated whether mucosal and …
