BackgroundBladder urothelial carcinoma (BUC) exhibits high recurrence and poor prognosis, with limited efficacy of current immunotherapies. The role of the aggrephagy-related gene TUBA1A in the BUC immune microenvironment remains unclear.MethodsSingle-…
IntroductionInflammation is implicated in Parkinson disease (PD), but the prognostic value of circulating cytokines beyond clinical information remains incompletely defined.MethodsWe studied cytokines measured in polymer-precipitated plasma extracellul…
Platelets are increasingly recognized as active amplifiers of neuroinflammation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). P2Y12 is an essential ADP receptor that regulates platelet activation and is upregulated in neuro…
BackgroundThe global prevalence of ischemic stroke (IS) and osteoporosis (OP) is rising, posing significant public health challenges in aging populations. We aimed to uncover shared genetic factors and elucidate the molecular mechanisms linking IS and …
Probiotics are widely recognized for their ability to promote gut health, modulate immunity, and reduce oxidative stress. As an emerging probiotic within the genus Weissella, Weissella koreensis (WK) exhibits promising immunomodulatory potential. Recen…
BackgroundPolycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental toxicants, yet the toxicological mechanisms by which they induce idiopathic pulmonary fibrosis (IPF) remain poorly understood. This study aims to systematically elucidate th…
IntroductionThe optimal frontline treatment option for Peripheral T-cell lymphomas (PTCLs) has not been completely defined.MethodsTo compare the efficacy and safety of brentuximab vedotin (BV) combined with CHP-like regimen (cyclophosphamide, an anthra…
Scientific problemStudying the acute, cell-intrinsic functions of signaling proteins in T cells has long been challenging. Existing constitutive or inducible gene deletion cannot overcome developmental adaptation that obscures true phenotypes. Similarl…
BackgroundLangerhans cell histiocytosis (LCH) is a rare pediatric disease with marked clinical heterogeneity. Current risk stratification relies on the extent of organ involvement and risk-organ status, yet reliable protein biomarkers for distinguishin…
ObjectiveReliable biomarkers for early interstitial lung disease (ILD) risk stratification are limited; therefore, we aimed to identify prediagnostic proteins associated with incident ILD and develop a long-term prediction model.MethodsWe analyzed 52,7…
