Kawasaki disease (KD) is an acute pediatric vasculitis with risk of coronary artery injury. A two-transcript IFI27–MCEMP1 score has distinguished KD from other febrile illnesses, but its relationship to long noncoding RNAs (lncRNAs) is incompletely def…
IntroductionLINC00887 plays critical roles in tumor biology, from oncogenesis to metastasis and drug resistance, while the specific mechanism in ccRCC remains unclear. We analyzed the expression profiles of LINC00887 and UPF1 and assessed their correla…
BackgroundPathological complete response (pCR) after neoadjuvant chemoimmunotherapy (NACI) varies among patients with non-small cell lung cancer (NSCLC). This study aimed to quantify intratumoral heterogeneity using habitat analysis and to develop a pr…
BackgroundThymectomy is an established treatment for thymoma-associated myasthenia gravis (MG). However, a subset of patients develop new-onset MG after surgery. Although thymectomy affects immune homeostasis, its comprehensive impact on the peripheral…
Thymocytes upregulate expression of recombination activating genes (RAGs) upon developmental transition from the CD4−CD8− double-negative to the CD4+CD8+ double-positive (DP) stage. Although enhanced RAG expression is necessary to generate a complete T…
Background and aimsHepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is associated with high short- and long-term mortality. Prior nucleos(t)ide analogue (NA) treatment history, particularly treatment withdrawal and virological resist…
ObjectivePeripheral immune-inflammatory activity may influence postoperative vascular remodeling in Moyamoya disease (MMD), but the relevant pathways may differ by developmental stage. We investigated age-dependent associations of blood cell-derived in…
BackgroundSelpercatinib is a highly selective rearranged during transfection (RET) receptor tyrosine kinase inhibitor approved for RET fusion-positive cancers and known to penetrate the blood–brain barrier. Although RET signaling has been implicated in…
A significant challenge in the study of neuroimmune responses is the identification and separation of resident microglia from infiltrating bone marrow-derived macrophages. Therefore, we investigated whether dual labelling of Cx3cr1 and Ccr2 is sufficie…
A significant challenge in the study of neuroimmune responses is the identification and separation of resident microglia from infiltrating bone marrow-derived macrophages. Therefore, we investigated whether dual labelling of Cx3cr1 and Ccr2 is sufficie…
