BackgroundSpinal cord injury (SCI) causes severe and persistent neurological dysfunction. Ferroptosis has been implicated in multiple neurological disorders, but its contribution to SCI and its relationship to myeloid-cell responses, inflammatory ampli…
BackgroundSepsis is a life-threatening syndrome with dysregulated immune responses and multiple organ dysfunction. However, precise diagnostic biomarkers and effective therapeutic targets for this syndrome are still lacking. Protein ubiquitination modu…
BackgroundCurrent therapeutic options for severe acute pancreatitis (SAP) remain limited. The integration of traditional Chinese and Western medicines offers a promising approach for patients with SAP, with Qingyi decoction (QYD) emerging as a classic …
Background and purposeInterferon-induced protein 27 (IFI27) is implicated in immune regulation, and regulatory T cells (Tregs) play a critical role in maintaining pulmonary immune homeostasis during sepsis. However, the relationship between IFI27 and T…
BackgroundMany variants within the ABO gene across multiple subtypes have been identified. These variants are located in the coding region, the erythroid-specific regulatory element region of intron 1, splice sites, and other non-coding regions. Howeve…
BackgroundIntervertebral disc degeneration (IVDD) is a major cause of chronic low back pain, characterized not only by extracellular matrix (ECM) degradation but also by a chronic low-grade inflammatory response. The crosstalk between immune microenvir…
BackgroundThis study aimed to investigate the role of myofiber-specific TGF-β signaling in the development of muscle inflammation by modulating Treg-cell-mediated macrophage efferocytosis.MethodsCTX-induced muscle injury was performed in the tibialis a…
Shigellosis is an intestinal infection causing severe and often life-threatening diarrheal disease, with high prevalence in children under five years of age in low- and middle-income countries. Given the rise of antimicrobial resistance to Shigella, th…
Background and aimsSeasonal influenza virus infections represent a global health threat, especially in high-risk groups, including patients with liver cirrhosis that are considered to be immunocompromised, in particular in decompensated stages. Althoug…
BackgroundProlonged indoor heat exposure disrupts immune homeostasis and can precipitate acute systemic inflammation. However, the core temperature threshold triggering sex-specific immune cell (leukocytes and neutrophils) mobilization during passive i…
