Bats represent the second largest order of mammals and are the only flying mammals, exhibiting remarkable biological characteristics such as viral tolerance, longevity, and low tumor incidence. Although bats serve as reservoirs for numerous zoonotic vi…
IntroductionInfectious salmon anemia virus (ISAV), the causative agent of infectious salmon anemia (ISA), is one of the most regulated pathogens affecting Atlantic salmon aquaculture globally. Recent investigations suggest a linkage between the host ge…
BackgroundHepatocellular carcinoma (HCC) with VP4 portal vein tumor thrombosis (PVTT) has a poor prognosis. Although hepatic arterial infusion chemotherapy (HAIC) combined with tyrosine kinase inhibitors (TKIs) and programmed cell death protein 1 (PD-1…
IntroductionHematological patients are at higher risk of severe SARS-CoV-2 infection and exhibit impaired vaccine responses due to disease and therapy. Treatments like Rituximab are known to compromise immune function, reducing the generation of protec…
X-linked adrenoleukodystrophy (X-ALD) is driven by ABCD1 dysfunction, causing very-long-chain fatty acid (VLCFA) accumulation and cerebral inflammation, yet the role of T cells in X-ALD remains unclear. Here, we show that Abcd1-deficient CD4+ T cells e…
BackgroundTriple-negative breast cancer (TNBC) has poor prognosis, largely due to its high rates of metastasis and recurrence. Anoikis plays a pivotal role in tumor metastasis; however, its role in TNBC remains elusive.MethodsCox regression analysis wa…
ObjectivesRheumatoid arthritis is more prevalent in women than in men, but rheumatoid arthritis-associated interstitial lung disease occurs more frequently and with greater severity in men. To address this paradox, we investigated whether sex- and tiss…
Genetic variation alone does not fully explain how marine organisms adapt locally; epigenetic mechanisms such as long non-coding RNAs (lncRNAs) may also contribute. This study explores expression differences associated with differentially expressed lnc…
BackgroundRhinolophus pusillus is currently the only known horseshoe bat that simultaneously harbors SARS-CoV-related coronaviruses (SARSr-CoVs), SARS-CoV-2-related coronaviruses (SC2r-CoVs), and a sarbecovirus recombinant lineage with a mosaic genome …
BackgroundStaphylococcus aureus (S. aureus) is the most common pathogen in musculoskeletal infections (MSKI). Application of antibody responses to S. aureus virulence factors have suggested to improve diagnostic specificity. Iron acquisition plays a cr…
