Atrial fibrillation (AF) is the most common cardiac arrhythmia, linked to greater risk of heart failure, stroke and death. Inflammation has been connected to AF emergence, however mechanisms of inflammation-caused AF remain thus far elusive, leading to…
IntroductionEndometrial receptivity is essential for implantation in both natural and ART cycles, yet the cellular and molecular environment of the endometrium during this window remains poorly characterized. While cytokines affecting implantation have…
BackgroundT-cell engagers (TCEs), “off-the-shelf” immunotherapies are seeing widespread clinical application, yet their real-world safety profile is not fully defined. This study aimed to characterize the comprehensive adverse event (AE) profile of TCE…
ObjectiveRecurrent spontaneous abortion (RSA) affects 0.5%–2.5% of fertile couples and arises from complex, interacting thrombotic, immune, coagulation, endocrine–metabolic, and demographic factors. However, current early risk stratification in routine…
IntroductionMetastatic recurrence drives dismal survival in esophageal squamous cell carcinoma (ESCC), yet epigenetic mechanisms underlying metastasis remain poorly defined. While DNMT1 and DNMT3A contribute to ESCC pathogenesis, DNMT3B’s role is enigm…
IntroductionPregnancy requires coordinated immunometabolic adaptations that allow maternal immune tolerance while preserving tissue remodeling and host defense. Circulating monocytes contribute critically to these processes, yet how gestation shapes th…
BackgroundAtlantic cod lack functional MHC class II and CD4, raising fundamental questions about how vaccination generates protection in this species. MethodsWe combined single-cell transcriptomic profiling of splenic cells with qRT-PCR across compleme…
IntroductionIt is becoming increasingly evident that SARS-CoV-2 infection is here to stay. Therefore, understanding whether genetic variants may impact the response to the virus or vaccination is crucial. Studies on the genetic determinants of immune …
BackgroundDonor-derived infections (DDIs) have become a significant cause of infection in organ transplant recipients. Elaborating on the species, distribution, and resistance of donor-derived pathogens (DDPs) holds important implications.MethodsA retr…
ObjectiveThe objective was to investigate the association between tonsillectomy and subsequent ankylosing spondylitis (AS) risk, with particular emphasis on racial disparities in disease susceptibility.MethodsA retrospective cohort study was conducted …
