Non-canonical open reading frames (ncORFs) encoded throughout the human genome can be translated into unconventional proteins, several of which are implicated in tumorigenesis through disruption of key regulatory pathways. Although previous studies sho…
BackgroundPulmonary fibrosis (PF) is a progressive interstitial lung disease driven in part by epithelial–mesenchymal transition (EMT), but the upstream epithelial regulators remain undefined, and conventional screens rarely separate causal drivers fro…
The frequent outbreaks of “water bubble disease” in recent years have emerged as a major bottleneck hindering the healthy and sustainable development of the Macrobrachium rosenbergii farming industry. This study aimed to confirm the pathogenicity of Ci…
BackgroundTriple-negative breast cancer (TNBC) is characterized by limited therapeutic options and frequent immune escape, while the molecular mechanisms linking tumor-intrinsic programs with antitumor immunity remain incompletely understood.MethodsLAR…
IntroductionImmune reconstitution following HLA-haploidentical hematopoietic cell transplantation (Haplo-HCT) is often delayed compared with HLA-identical transplantation, which frequently poses clinical challenges. The reasons for these differences in…
BackgroundChimeric antigen receptor (CAR)-engineered cells are being investigated for urothelial carcinoma, but evidence requirements for antigen selection and local or systemic delivery remain undefined. We asked whether any target or route can presen…
BackgroundAntibody-mediated rejection remains the leading cause of kidney allograft failure in pediatric recipients. While non-HLA antibodies targeting G protein-coupled receptors, particularly anti-endothelin-1 type A receptor (ETAR) antibodies, have …
ObjectiveTo assess the CT-referenced diagnostic performance of short-echo time (TE) first-echo images derived from a T2* mapping acquisition for detecting sacroiliac joint (SIJ) structural lesions in patients evaluated for axial spondyloarthritis (axSp…
BackgroundBladder urothelial carcinoma (BUC) exhibits high recurrence and poor prognosis, with limited efficacy of current immunotherapies. The role of the aggrephagy-related gene TUBA1A in the BUC immune microenvironment remains unclear.MethodsSingle-…
IntroductionInflammation is implicated in Parkinson disease (PD), but the prognostic value of circulating cytokines beyond clinical information remains incompletely defined.MethodsWe studied cytokines measured in polymer-precipitated plasma extracellul…
