The “Christchurch” protective variant in the APOE gene has recently been identified, but its mechanisms of action remain unknown. In this issue of Immunity, Naguib and Lopez-Lee et al. provide evidence for the APOE-Christchurch variant suppressing micr…
Understanding fundamental lymphocyte biology and developing innovative strategies to harness lymphocytes to treat human diseases were the themes of the first SMART Symposium in Immunology held in March 2025 in Shenzhen, China.
Phospholipids regulate immune cell functions through both intracellular and extracellular mechanisms, engaging lipid-modifying enzymes, cell surface receptors, and lipid mediators such as lysophosphatidic acid (LPA), sphingosine 1-phosphate, and prosta…
In the letter to Immunity, Morris et al.1 discuss the possible regulatory mechanism of phospholipid phosphate phosphatase 1 (PLPP1) in CD8+ T cell activity. Here, we conduct an in-depth analysis of our work and other published studies, identifying pote…
Regulatory T (Treg) cells maintain immune and tissue homeostasis. In this issue of Immunity, Bündgen et al. find that intratumoral polyamines promote immunosuppressive Treg cells via CK2. Targeting the polyamine-CK2 axis shifts Treg cells to become tis…
Pulmonary immunity must strike a precise balance between protecting the delicate mucosal tissue from environmental threats and preserving its vital gas-exchange function. In this issue of Immunity, Li et al. and Hiroki et al. illuminate how the nervous…
ICOS agonists are being investigated for cancer immunotherapy based on the idea that they will reinvigorate exhausted CD8+ T cell anti-cancer immunity. Humblin et al. unexpectedly find the opposite—that CD8+ T cell-intrinsic ICOS expression restrains r…
Mitochondrial reactive oxygen species (mtROS) serve as critical signaling molecules that regulate immunity. Chandel et al. review the spectrum of mtROS effects, ranging from essential roles in innate immune activation and T cell differentiation to path…
Neutrophils are highly dynamic immune cells with diverse phenotypes shaped by development, tissue-specific signals, and disease contexts. This perspective proposes a four-tiered framework integrating maturation, tissue localization, and function to sta…
Mutations in MLL3, encoding the histone methyltransferase MLL3/KMT2C, are frequent in various cancer types. Boutet, Nishitani, et al. show that the loss of MLL3 stabilizes HIF1α, which induces expression of the chemokine CCL2 and promotes infiltration …
