inmunoadmin Cancer Immunol Res. 2026 Sep 4:OF1-OF2. doi: 10.1158/2326-6066.CIR-26-0906. Online ahead of print. ABSTRACT The therapeutic potential of chimeric antigen receptor (CAR) T cells has long been limited by the static nature of the engineered receptor; once manufactured, the cell is committed to a single antigen, unable to respond to the immune evasion and antigen heterogeneity … Read more
J Leukoc Biol. 2026 Sep 4:qiag121. doi: 10.1093/jleuko/qiag121. Online ahead of print. ABSTRACT As a scientist, teacher, research mentor, and mom, I asked myself, “what is my legacy?” Legacies usually have numbers associated with them. When asked this question in the past, I summed my accomplishments in terms of who, not what. First and foremost, … Read more
Semin Immunol. 2026 Sep 3:102058. doi: 10.1016/j.smim.2026.102058. Online ahead of print. NO ABSTRACT PMID:42692896 | DOI:10.1016/j.smim.2026.102058
J Immunol. 2026 Aug 29;215(9):vkag224. doi: 10.1093/jimmun/vkag224. ABSTRACT Hepatic ischemia-reperfusion (I/R) injury triggers release of small extracellular vesicles (sEVs) that can function as systemic conveyors of inflammatory signals. While sEV-mediated immune cell modulation has been studied extensively in vitro, knowledge is based largely on sEVs derived from cultured cells, rather than injured tissues. Consequently, the … Read more
Cancer Immunol Res. 2026 Sep 2;14(9):1369. doi: 10.1158/2326-6066.CIR-14-9-WWR. NO ABSTRACT PMID:42682071 | DOI:10.1158/2326-6066.CIR-14-9-WWR
Circulating antigen-reactive CD4+ T cells and antibody responses in serum and lavage against the ETEC noncanonical virulence factors EatA, EtpA, and YghJ were found in volunteers experimentally infected with ETEC. This documents the immunogenicity of these antigens and supports their further evaluation as ETEC vaccine candidates. ABSTRACT A broadly protective licensed vaccine against enterotoxigenic Escherichia … Read more
Trends Immunol. 2026 Sep 1:S1471-4906(26)00220-6. doi: 10.1016/j.it.2026.08.004. Online ahead of print. ABSTRACT Multiple myeloma remains incurable despite therapeutic advances. Longitudinal profiling of bone marrow and peripheral blood by Chander et al. reveals selective persistence of malignant plasma cell states, compartment-specific immune remodeling, incomplete humoral recovery after autologous stem cell transplantation, and divergent vaccine responses. PMID:42680673 … Read more
J Immunol. 2026 Aug 29;215(9):vkag178. doi: 10.1093/jimmun/vkag178. ABSTRACT Neutrophils have been implicated in mediating immune crosstalk between injured tissue and distal organs, either promoting local and distal inflammation or mediating tissue repair. Skin injury from ultraviolet (UV) light triggers neutrophil migration to the kidney, which may have implications for nephritis flares in systemic lupus erythematosus. … Read more
J Clin Immunol. 2026 Jul 24;46(1):86. doi: 10.1007/s10875-026-02054-6. ABSTRACT Down syndrome (DS), caused by trisomy 21, is characterized by complex immune dysregulation that increases susceptibility to infections and alters vaccine responsiveness. Gene dosage effects involving interferon receptor loci on chromosome 21 contribute to chronic type I interferon hyperactivation, sustained JAK-STAT signaling, and persistent expression of … Read more
Cancer Immunol Res. 2026 Aug 31. doi: 10.1158/2326-6066.CIR-26-0177. Online ahead of print. ABSTRACT Immune checkpoint blockade (ICB) has markedly improved overall survival in various cancers, but is associated with severe and sometimes fatal immune-related adverse events (irAEs). Current management of irAEs involves discontinuation of ICB therapy and administration of immunosuppressive drugs, such as corticosteroids, which … Read more
