inmunoadmin

Histone H3K18 Lactylation Drives Immunosuppression by Upregulating CD38 in Myeloid-Derived Suppressor Cells in Lung Cancer

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Cancer Immunol Res. 2026 Sep 18. doi: 10.1158/2326-6066.CIR-25-1401. Online ahead of print. ABSTRACT Histone lactylation is an epigenetic modification that connects lactate metabolism with protein function. Our study identified lactate enhances the protein lactylation level not only in Myeloid-derived suppressor cells (MDSCs) of tumor-bearing mice, but also in the tumor tissues of lung cancer patients. … Read more

Exacerbation of inflammatory bone loss in TET2-driven clonal hematopoiesis

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J Immunol. 2026 Aug 29;215(9):vkag248. doi: 10.1093/jimmun/vkag248. ABSTRACT Clonal hematopoiesis of indeterminate potential (CHIP) arises from age-related somatic mutations in hematopoietic stem cells in the bone marrow (BM), driving clonal expansion and altered phenotypes. Loss-of-function mutations in the epigenetic regulator TET2 are among the most frequent in CHIP and increase the risk of hematologic malignancies … Read more

Cellular stress leading to epithelial cell dysfunction in Sjögren’s syndrome

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Curr Opin Immunol. 2026 Sep 17;103:102838. doi: 10.1016/j.coi.2026.102838. Online ahead of print. ABSTRACT Cells are highly compartmentalized entities composed of membranous and nonmembranous structures, where organelles such as the endoplasmic reticulum (ER), Golgi apparatus, nucleus, mitochondria, lysosomes, peroxisomes, endosomes, and plasma membrane are organized. The plasma membrane physically and functionally connects the cytoplasm to the … Read more

Clinical relevance of antiphosphatidylserine/prothrombin antibodies in antiphospholipid syndrome

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Curr Opin Immunol. 2026 Sep 17;103:102842. doi: 10.1016/j.coi.2026.102842. Online ahead of print. ABSTRACT Antiphospholipid syndrome (APS) is characterised by thrombosis and/or pregnancy morbidity associated with persistent antiphospholipid antibodies (aPL). Beyond the criteria antibodies, non-criteria aPL, particularly antiphosphatidylserine/prothrombin (aPS/PT), have emerged as clinically relevant aPL in the diagnosis of APS. aPS/PT antibodies, especially IgG, are strongly … Read more

Pre-existing immunity and hrHPV status determine immunotherapy response in advanced penile cancer: biomarkers and overall survival in the PERICLES trial

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Cancer Immunol Res. 2026 Sep 17. doi: 10.1158/2326-6066.CIR-26-0236. Online ahead of print. ABSTRACT Penile squamous cell carcinoma (PeSCC) is a rare malignancy with limited treatment options in advanced stages. The phase II PERICLES trial (NCT03686332) investigated atezolizumab with or without radiotherapy in advanced penile cancer. Here, we report mature overall survival (OS) and updated progression-free … Read more

Immunopeptidomics-driven MHC class II peptide-binding motif discovery for 2 common canine DR alleles

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J Immunol. 2026 Aug 29;215(9):vkag243. doi: 10.1093/jimmun/vkag243. ABSTRACT Despite the central role of major histocompatibility complex (MHC) class II in adaptive immunity, peptide-binding motifs have yet to be characterized for any canine MHC class II allele. Here, we report the first immunopeptidomics-derived binding motifs for DLA-DRB1*015:01 (DLA-DR15) and DLA-DRB1*012:01 (DLA-DR12), 2 alleles overrepresented in breeds … Read more

Erythropoietin impacts immune adaptation through myeloid-cell programming. Xiangyue Zhang

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Trends Immunol. 2026 Sep 16:S1471-4906(26)00230-9. doi: 10.1016/j.it.2026.08.014. Online ahead of print. ABSTRACT The immune system balances protective immunity against pathogens with tolerance to self and selected foreign antigens. Emerging evidence identifies erythropoietin (EPO) as a systemic immunoregulatory signal that links physiological stress to immune adaptation. Beyond its canonical role in erythropoiesis, EPO-EPO receptor (EPOR) signaling … Read more

Dendritic cells as programmable platforms for cancer immunotherapy. Yuchen Liu

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Trends Immunol. 2026 Sep 16:S1471-4906(26)00229-2. doi: 10.1016/j.it.2026.08.013. Online ahead of print. ABSTRACT Dendritic cells (DCs) are professional orchestrators of the immune system, integrating environmental signals to initiate, modulate, and sustain antitumor immunity. Although their therapeutic potential extends beyond antigen delivery, most clinical strategies have used DCs primarily as cellular vaccines. Here, we propose that DCs … Read more

Leishmania inhibits NLRP3 expression through IL-33/ST2 signaling driven SOCS1-mediated p65 degradation

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J Immunol. 2026 Aug 29;215(9):vkag246. doi: 10.1093/jimmun/vkag246. ABSTRACT The dynamic interplay between pro- and anti-inflammatory cytokines plays a crucial role in regulating host immune responses. In our earlier study, we showed that Leishmania donovani-induced IL-33 destabilizes host cytokine dynamics by downregulating TNF-α and IL-12 and ensures intramacrophage parasite survival. Another pertinent host favorable proinflammatory cytokine … Read more

MRP8‐Cre Transgenic Mice Are Resistant to Weight Gain and Diet‐Induced Obesity Independently of Neutrophils. [[{“value”:”Stephan Forisch, Fatemeh Soltani, Laia Salvat Costa, Beatriz M. Cardoso, Yaiza Moreno Galiano, Cedric Duval, Robert A. S. Ariëns, Navdeep S. Chandel, Mari T. Kaartinen, Stefanie K. Wculek”}]]

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The MRP8Cre mouse model is frequently used to investigate the biology of neutrophils. This study reports that MRP8Cre transgenic have a lower body weight and improved metabolic health, especially after high fat diet feeding, which correlates with decreased Serpine1/PAI-1 expression in metabolic organs. Image created with BioRender.com. ABSTRACT Obesity is a major risk factor for … Read more

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