inmunoadmin J Leukoc Biol. 2026 May 13;118(5):qiag060. doi: 10.1093/jleuko/qiag060. NO ABSTRACT PMID:42124390 | DOI:10.1093/jleuko/qiag060
Nur77 is associated with a TCF-1+ memory-like, polyfunctional profile in virus-specific human CD8+ T cells across acute-resolved, vaccinated, and chronic viral infections, and its pharmacologic modulation in vitro enhances the functionality of dysfunctional HIV- and HBV-specific CD8+ T cells in chronic co-infections. ABSTRACT Human CD8+ T cells undergo significant metabolic and transcriptional shifts during activation … Read more
J Immunol. 2026 Apr 15;215(4):vkag093. doi: 10.1093/jimmun/vkag093. ABSTRACT Major histocompatibility complex class II molecules present exogenous antigen-derived peptide to CD4+ T cells leading to T cell activation as well as signaling into the antigen-presenting cell. Class II is an αβ heterodimer that forms 2 distinct conformers via differential pairing of transmembrane domain GxxxG motifs (i.e. … Read more
J Immunol. 2026 Apr 15;215(4):vkag076. doi: 10.1093/jimmun/vkag076. ABSTRACT A large body of evidence indicates that Th17 cells play essential roles in mucosal immune responses and trigger autoimmune diseases, including multiple sclerosis, inflammatory bowel disease, and psoriasis. Targeting Th17 cells holds promise for therapeutic innovation. While the core cytokine signaling networks driving Th17 differentiation have been … Read more
J Immunol. 2026 Apr 15;215(4):vkag077. doi: 10.1093/jimmun/vkag077. ABSTRACT Tissue-resident monocyte-lineage cells (TRMCs) are an extravascular population distinct from circulating monocytes and synovial macrophages and are critical for the development of inflammatory arthritis. However, the precise identities and origins of TRMC subpopulations remain unclear. Here, we characterize the ontogeny of TRMCs, which are comprised of bone … Read more
J Leukoc Biol. 2026 May 12:qiag058. doi: 10.1093/jleuko/qiag058. Online ahead of print. ABSTRACT Increased sensory nerve density has been described in type II inflammatory conditions and is linked to eosinophil and mast cell infiltration and neuropathic pain. To examine these relationships in eosinophilic gastrointestinal diseases (EGIDs), we developed a protocol using Clearing-enhanced 3D (Ce3D) tissue … Read more
Cancer Immunol Res. 2026 May 11. doi: 10.1158/2326-6066.CIR-25-0691. Online ahead of print. ABSTRACT CD19-directed chimeric antigen receptor (CAR) T-cell therapy has significantly advanced the treatment landscape for relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL). However, up to 60% of patients do not achieve a complete response. To uncover determinants of therapeutic efficacy, we analyzed the … Read more
Mucosal Immunol. 2026 May 7:100348. doi: 10.1016/j.mucimm.2026.100348. Online ahead of print. ABSTRACT Commensal microbes can cause invasive infection but can also stimulate protective immune responses as exemplified by the gut pathobiont Candida albicans. This species primes systemic Th17 immunogenicity which protects against disseminated infection, and yet the fungal determinants driving protection remain uncertain. Here we … Read more
J Clin Immunol. 2026 May 9. doi: 10.1007/s10875-026-02027-9. Online ahead of print. ABSTRACT The Janus Kinase 3 (JAK3) germline gain-of-function (GOF) mutation is a rare inborn error of immunity, first reported in 2020, characterized by lymphopenia and chronic NK-cell proliferation. However, its role in autoimmunity remains unclear, and no direct association with hyper-IgE syndrome (HIES) … Read more
J Immunol. 2026 Apr 15;215(4):vkag086. doi: 10.1093/jimmun/vkag086. ABSTRACT Hematopoietic stem cell transplantation as treatment for patients with leukemia relies on chemotherapy and/or irradiation-based conditioning regimens to prevent graft rejection and cancer relapse. Despite advances in radiotherapy, total body irradiation for myeloablative conditioning is associated with dose and temporal heterogeneity, and how these variables impact thymus … Read more
