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Streptococcus anginosus Activates the NLRP3 Inflammasome to Promote Inflammatory Responses from Macrophages​Anika M Arias on 8 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 8:qiag061. doi: 10.1093/jleuko/qiag061. Online ahead of print. ABSTRACT Chronic inflammation and oral dysbiosis are common features of oral squamous cell carcinoma (OSCC). The commensal streptococci, S. anginosus, is increased in oral diseases including OSCC. Our previous work revealed that S. anginosus promotes inflammatory responses from macrophage cell lines, however the … Read more

Mapping of Neutrophils in Cancers: Insights From Spatial Omics Technologies. [[{“value”:”Xiaohe Li, Xi He, Shan Cao, Changming Shih, Xiaoxiang Chen, Lai Guan Ng”}]]

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The evolving landscape of transcriptomic technologies tailored for neutrophil research. ABSTRACT Tumor neutrophils exhibit marked phenotypic plasticity and can play dual roles in tumor biology, encompassing both tumor-promoting and tumor-suppressive activities. Single-cell RNA sequencing (scRNA-seq) enables transcriptomic profiling of tumor neutrophils at single-cell resolution, whereas spatial transcriptomics (ST) addresses key limitations of scRNA-seq by preserving … Read more

Unfavourable H‐CDR3 Loops in preB Cells Lead to Highly Expanded Plasma Cell Clones. [[{“value”:”Alaitz Aranburu, Erik Engström, Erik Demitz‐Helin, Julia M. Scheffler, Alessandro Camponeschi, Timothy Sundell, Zhong Ni, Inga‐Lill Mårtensson”}]]

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In the absence of a pre-BCR, a subset of mature B cells that expresses IgH chains with very short, hydrophobic and positively charged H-CDR3 loops is generated. This results in massive clonal expansion and the development of autoreactive plasma cells exhibiting these characteristics. ABSTRACT The immune system is essential for protection against invading pathogens. However, if … Read more

CD8 T Cell Sensing of Type I Interferon Impacts Anergy. [[{“value”:”Anne S. Haefke, Hanna Gröber, Ioana Sandu, Vanessa Skipness, Nikos Pantouloufos, Fabienne Gräbnitz, Marie‐Elen Tuchel, Nathan Zangger, Dominique Stark, Marvin Kříž, Carmine Cristinzio, Hanspeter Pircher, Roman Spörri, Isaak Quast, Annette Oxenius”}]]

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Basal IFN-I acts as a rheostat to fine-tune CD8 T cell anergy. The presence of IFN-I induces a less deep anergic state characterised by greater expansion, residual effector function and plasticity. This favours the accumulation of autoreactive T cells that retain the potential to break tolerance rather than undergoing deletion. Created in BioRender (2026). https://BioRender.com/y0syq8s … Read more

Integrins in engraftment of ex vivo generated plasma cells

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J Immunol. 2026 Apr 15;215(4):vkag084. doi: 10.1093/jimmun/vkag084. ABSTRACT Plasma cells (PCs) are terminally differentiated B cells that are long-lived and have high rates of protein secretion. Because of these features, ex vivo generated PCs are being developed as therapeutics for long-term protein delivery. Here, we used proteomics and flow cytometry-based approaches to comprehensively interrogate the … Read more

Role of Ca2+-activated KCa3.1 potassium channel in CAR T cell effector function

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J Immunol. 2026 Apr 15;215(4):vkag078. doi: 10.1093/jimmun/vkag078. ABSTRACT Genetically modified chimeric antigen receptor (CAR) T cells eliminate tumors by recognizing specific antigens on the cell surface. T cell ion channels (e.g. Kv1.3, KCa3.1) influence activation, proliferation, and effector functions such as target cell killing, through the regulation of Ca2+ signaling. We showed that CAR-expressing cells … Read more

An overview of human inflammasomes: Activation and regulation

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J Immunol. 2026 Apr 15;215(4):vkag081. doi: 10.1093/jimmun/vkag081. ABSTRACT The innate immune system has evolved as the primary response mechanism against microbial infections, tissue damage, and cellular stress. Signals that disrupt homeostasis are sensed by pattern recognition receptors and initiate innate immune responses to restore homeostasis. Some intracellular pattern recognition receptors belonging to the Nod-like receptor, … Read more

GLUT1-mediated glucose flux constrains autoreactive but not foreign antigen-specific B-cell responses

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J Immunol. 2026 Apr 15;215(4):vkag092. doi: 10.1093/jimmun/vkag092. ABSTRACT Emerging evidence from lupus-prone mice and patients with systemic lupus erythematosus implicates enhanced glycolysis in lymphocytes as a driver of disease. We previously showed that the pharmacologic blockade of glycolysis reduced the production of autoantibodies without affecting antibodies induced by immunization to a foreign protein. Here we … Read more

The sweet truth about germinal centers. Vishal N Rao

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Trends Immunol. 2026 May 5:S1471-4906(26)00098-0. doi: 10.1016/j.it.2026.04.005. Online ahead of print. ABSTRACT Glycan-specific antibodies are classically associated with limited durability. In a recent Immunity article, Fryer et al. showed that repeated Streptococcus pyogenes exposure elicits glycan-specific germinal center responses in tonsils despite reduced T cell help, revealing key limitations of anti-glycan immunity and opportunities to … Read more

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