inmunoadmin

Access to CAR-T therapy in Latin America: Barriers, gaps, and pathways forward. Jorge Contreras

by

Semin Immunol. 2026 May 5;82:102029. doi: 10.1016/j.smim.2026.102029. Online ahead of print. ABSTRACT Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematological malignancies, offering durable responses in conditions such as diffuse large cell lymphoma, B-cell leukemias and multiple myeloma. However, access to this therapy is still limited in low- and middle-income nations, … Read more

Automated Computational Flow Cytometry Correlates Decreasing Neutrophil-to-Lymphocyte Ratio to Improved Survival in NSCLC After Immune Checkpoint Blockade

by

Cancer Immunol Res. 2026 May 6. doi: 10.1158/2326-6066.CIR-25-0662. Online ahead of print. ABSTRACT Immune checkpoint blockade (ICB) therapy is transforming non-small cell lung cancer (NSCLC) treatment and prolonging overall survival (OS). However, not all patients are responsive. Using computational cytometry analysis to identify immune cell subsets and early dynamic changes, we aimed to unravel the … Read more

Comprehensive Profiling of T- and B-Cell Receptor Repertoires Demonstrates Impaired Developmental and Activation of Adaptive Immunity in DOCK8 Deficiency

by

J Clin Immunol. 2026 May 6. doi: 10.1007/s10875-026-02031-z. Online ahead of print. ABSTRACT Dedicator of cytokinesis protein 8 (DOCK8) is a crucial regulator for the formation of immune synapses, allowing for a proper function of innate and adaptive immune systems. DOCK8 deficiency is a primary immunodeficiency, currently known as Inborn Errors of Immunity (IEI) affecting … Read more

The role of different aPL subpopulations in the lupus anticoagulant phenomenon

by

Curr Opin Immunol. 2026 May 4;100:102784. doi: 10.1016/j.coi.2026.102784. Online ahead of print. ABSTRACT The lupus anticoagulant (LA) phenomenon represents a paradoxical prothrombotic state characterised by inhibition of phospholipid-dependent coagulation assays in vitro, despite a strong association with thrombosis and pregnancy morbidity in vivo. LA is a central laboratory criterion for the diagnosis and risk stratification … Read more

Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung​Heather Mathie on 5 de May de 2026 at 10:00

by

J Leukoc Biol. 2026 May 6:qiag059. doi: 10.1093/jleuko/qiag059. Online ahead of print. ABSTRACT CCR1, CCR2 and CCR5 direct recruitment of monocytes and macrophages in inflammation. However, the discrete role for each receptor in monocyte/macrophage biology remains poorly understood, with previous reports citing receptor redundancy. Using transcriptomic approaches to examine inflammatory chemokine receptor expression on lung … Read more

Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil​Ágata Lopes-Ribeiro on 5 de May de 2026 at 10:00

by

J Leukoc Biol. 2026 May 5:qiag050. doi: 10.1093/jleuko/qiag050. Online ahead of print. ABSTRACT Despite advanced knowledge on the SARS-CoV-2-induced immunity, a deeper understanding of how virus-specific responses are assembled upon infection is necessary. Therefore, the present work investigates the MHC-restricted virus-specific responses of acute and post-acute COVID-19 patients. Our results indicate that convalescent individuals displayed … Read more

UBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation

by

Cancer Immunol Res. 2026 May 5. doi: 10.1158/2326-6066.CIR-25-1321. Online ahead of print. ABSTRACT Osteosarcoma (OS) responds poorly to immune-checkpoint blockade (ICB), and the molecular drivers of its immune-cold state remain unclear. Using multi-omics analyses, we identified an immune-cold OS subtype characterized by enrichment of protein SUMOylation and found the SUMO E1 subunit UBA2 as a … Read more

Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System. [[{“value”:”Zara Karami, Hadewych J. M. ter Hofstede, Leo A. B. Joosten”}]]

by

Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva-mediated suppression of innate defenses, TLR2/NOD2-driven cytokine dysregulation, and interference with JAK/STAT and CIITA-dependent antigen presentation. Impaired autophagy skews responses toward pathogenic Th17 activity, while disrupted lymph node architecture, persistent IgM, and defective CD4+ T cell function collectively impair … Read more

Spatial Multiomics Reveal Insights Into ADC Efficacy. [[{“value”:”Osman Goni, Niklas Klümper, Maria del Mar Muñiz Moreno, Markus Eckstein, Christoph Kuppe”}]]

by

Spatial multiomics profiling can reveal how tumor heterogeneity and microenvironment influence ADC efficacy. Combining spatial transcriptomics, proteomics, and AI-based analysis improves the identification of tissue factors influencing therapy response. This integrative approach potentially enables prediction of response, resistance, and optimized patient selection, which we review here. ABSTRACT Antibody–drug conjugates (ADCs) have transformed the therapeutic landscape … Read more

SYK Signalling in NLRP3 Inflammasome‐Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG. [[{“value”:”Kristina Mašalaitė, Milda Norkienė, Aurelija Žvirblienė, Asta Lučiūnaitė”}]]

by

IC-mediated inflammatory response—the NLRP3 inflammasome activation, cytokine secretion, and antigen presentation depend on SYK signalling pathways in primary murine microglia. ABSTRACT Viral infections might trigger systemic inflammatory responses characterised by inflammasome activation and cytokine release, driven by immune complex (IC) formation, but the precise mechanism remains unknown. The NLRP3 inflammasome is a vital component of … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri cURL Hatası: Could not resolve host: lkl.dolarkurum.com