inmunoadmin Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more
An attenuated live vaccine (OTS-300) expressing the XBB.1.5 Spike provided rapid and complete protection against homologous challenge in the hamster model, accompanied by fast systemic and mucosal antibody responses and markedly reduced transmission compared with XBB.1.5 mRNA vaccination. Therefore, vaccination with the OTS LAV platform may help to disrupt transmission chains. ABSTRACT The emergence of … Read more
Cancer Immunol Res. 2026 May 4;14(5):715. doi: 10.1158/2326-6066.CIR-14-5-WWR. NO ABSTRACT PMID:42076931 | DOI:10.1158/2326-6066.CIR-14-5-WWR
Mucosal Immunol. 2026 May 1:100347. doi: 10.1016/j.mucimm.2026.100347. Online ahead of print. ABSTRACT Eosinophils have traditionally been viewed as terminally differentiated type 2 effector cells involved in anti-helminth immunity and allergic inflammation. Recent advances in single-cell transcriptomics have refined this view, revealing substantial developmental and functional heterogeneity across tissues and inflammatory settings. Eosinophil development in the … Read more
Semin Immunol. 2026 May 2;82:102028. doi: 10.1016/j.smim.2026.102028. Online ahead of print. ABSTRACT Chagas disease (ChD) and Type 2 diabetes (T2D) originate from distinct etiological processes -infectious and metabolic, respectively- yet both share a chronic inflammatory and metabolic imbalance that profoundly impacts immune-endocrine homeostasis. Persistent Trypanosoma cruzi infection in ChD induces sustained immune activation, altered adrenal … Read more
Trends Immunol. 2026 May 1:S1471-4906(26)00097-9. doi: 10.1016/j.it.2026.04.004. Online ahead of print. ABSTRACT Itaconate is an immunomodulatory metabolite that links metabolism and inflammation. Li et al. uncover a mechanism by which itaconate and 4-octyl itaconate suppress cytokine signaling through the alkylation of tyrosine kinase 2 and Janus kinase 1. This study reveals a direct metabolic control … Read more
Curr Opin Immunol. 2026 Apr 30;100:102782. doi: 10.1016/j.coi.2026.102782. Online ahead of print. ABSTRACT Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by fluctuating multisystem involvement, relapsing-remitting activity, and substantial risk of irreversible organ damage. Standardized disease activity indices have facilitated clinical trials and research, yet integration into clinical practice has not occurred for … Read more
Trends Immunol. 2026 Apr 30:S1471-4906(26)00076-1. doi: 10.1016/j.it.2026.03.015. Online ahead of print. ABSTRACT Sickness, or sickness behavior, is a state of altered physiology and behavior generated by the brain-immune axis during infection, which is generally assumed to contribute to host defense. Here, we examine this assumption by framing sickness as organismal-scale immunity and explore predicted parallels … Read more
Curr Opin Immunol. 2026 Apr 29;100:102783. doi: 10.1016/j.coi.2026.102783. Online ahead of print. ABSTRACT Allogeneic hematopoietic cell transplantation (alloHCT) is curative for many patients with high-risk, hematologic malignancies. AlloHCT depends on a graft versus malignancy (GVM) phenomenon, whereby donor-derived immune cells recognize and eradicate malignant host cells. Successful GVM correlates with the risk of alloreactivity against … Read more
Mucosal Immunol. 2026 Apr 27:S1933-0219(26)00048-6. doi: 10.1016/j.mucimm.2026.04.007. Online ahead of print. ABSTRACT Influenza virus infection can result in outcomes ranging from moderate, self-limiting illness to severe, life-threatening disease. Although severe cases are frequently associated with CD8+ T cell lymphopenia, the underlying mechanisms driving this diminished T cell response remain poorly defined. Here, we investigated how … Read more
