Mechanoinflammation: mechanosensing and inflammatory amplification through the airway macrophage Piezo1–NLRP3 axis in cough-variant asthma
Cough-variant asthma (CVA) is characterized by chronic dry cough as its predominant manifestation, lacking the wheezing typical of classic asthma. Violent paroxysmal coughing generates distinct mechanical loads across different airway segments: the lar…