Neutrophil extracellular traps (NETs), long recognized as effectors of innate host defense, are now firmly implicated in remodeling the tumor microenvironment and facilitating tumor progression. Tumor-associated NETs expose proteases, damage-associated…
Colorectal anastomotic leakage is commonly framed as a technical complication or a consequence of intestinal dysbiosis. Neither view fully explains how a contaminated mucosal wound restores epithelial continuity while preserving a load-bearing submucos…
Brain-computer interfaces (BCIs) have made significant progress in fields such as neurorehabilitation, motor reconstruction, and alternative communication by capturing, decoding, and providing feedback on brain activity. In contrast, the application of…
Intravenous thrombolysis and mechanical thrombectomy have transformed acute ischemic stroke (AIS) care, yet angiographic recanalization does not guarantee adequate tissue reperfusion or long-term functional independence. Brain cytoprotection has theref…
N6-methyladenosine (m6A) represents the most prevalent modification on eukaryotic RNA and plays a critical role in nearly all stages of RNA expression regulation. Extensive research demonstrates that the dysregulation of m6A modification plays a signif…
Severe pneumonia-associated lung injury is a major cause of acute respiratory failure, acute respiratory distress syndrome (ARDS), and death in critically ill patients. Its course is shaped within the critically ill host environment by pulmonary infect…
Chimeric antigen receptor (CAR) T-cell therapy has transformed the treatment landscape of hematological malignancies; however, its broader clinical implementation remains constrained by the complexity, cost, and variability of current manufacturing wor…
Inflammatory bowel disease (IBD), encompassing Crohn’s disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract characterized by dysregulated immune responses, impaired epithelial barrier function, and …
Macrophageexhibit remarkable functional plasticity and adopt M1-like pro-inflammatory or M2-like anti-inflammatory/pro-resolving states in response to microenvironmental stimuli. Notably, this binary functional classification originates largely from in…
Intrahepatic cholangiocarcinoma (iCCA) is an aggressive liver malignancy characterized by pronounced cellular, spatial, and metabolic heterogeneity. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) are beginning to resolve this c…
