Yang Li Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies due to profound biological heterogeneity, complex stromal organization, and limited responsiveness to current immunotherapies. Recent advances in single-cell seque…
BackgroundPatients with rheumatoid arthritis (RA) frequently experience increased physical pain and impaired self-perception. However, the combined impact of the pan-immune-inflammation value (PIV) and the visual analogue scale (VAS), representing subj…
BackgroundAvacopan is an oral selective C5a receptor inhibitor. It received FDA approval in October 2021 for use with standard glucocorticoid therapy to treat antineutrophil cytoplasmic antibody-associated vasculitis. However, there are limitations to …
BackgroundRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial inflammation and progressive joint destruction. Neutrophil extracellular traps (NETs), a microreticular structure formed after neutrophil death, have recently…
BackgroundGlycosyltransferase-associated genes play a crucial role in hepatocellular carcinoma (HCC) pathogenesis. This study investigates their impact on the tumor microenvironment and molecular mechanisms, offering insights into innovative immunother…
Ovarian cancer, ranking as the seventh most prevalent malignancy among women globally, faces significant challenges in diagnosis and therapeutic intervention. The difficulties in early detection are amplified by the limitations and inefficacies inheren…
In the advancement of Inflammatory Bowel Disease (IBD) treatment, existing therapeutic methods exhibit limitations; they do not offer a complete cure for IBD and can trigger adverse side effects. Consequently, the exploration of novel therapies and mul…
