BackgroundMyelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune inflammatory demyelinating disorder of the central nervous system with a broad clinical spectrum that includes brainstem syndromes. Evidence supporting n…
BackgroundStrongyloides hyperinfection syndrome (SHS) is a life-threatening condition in immunocompromised hosts with an extremely high mortality rate. Metagenomic next-generation sequencing (mNGS) demonstrates limited sensitivity for parasitic detecti…
BackgroundThe underlying pathophysiological mechanisms of proteinuria relapse in lupus nephritis (LN) patients during immunological remission are complex, often involving non-immune complex-mediated podocyte injury.Case presentationWe report a 21-year-…
BackgroundImmune checkpoint inhibitors (ICIs) have become the standard treatment for patients with advanced microsatellite instability-high (MSI-H) gastric cancer. However, the incidence of immune-related adverse events (irAEs) has also increased accor…
BackgroundSevere autoimmune liver injury as the first manifestation of systemic lupus erythematosus (SLE) is rare, and concomitant autoimmune hepatitis–primary biliary cholangitis (AIH–PBC) overlap is uncommon. B-cell-activating factor (BAFF) provides …
Generalized pustular psoriasis (GPP) is a rare, severe, and potentially life-threatening neutrophilic dermatosis. Management focuses on rapid control of acute flares and prevention of recurrence. Advances in understanding the central role of interleuki…
Immune-related cholangitis is a rare immune-related adverse event, and its diagnostic criteria and treatment strategies have not yet been established. Here, we report a case of immune-related cholangitis in which treatment response could be objectively…
BackgroundApparent transitions in carbapenem susceptibility among sequential Klebsiella pneumoniae isolates are often interpreted as strain replacement. However, phenotypic variation among closely related isolates may also produce similar phenotypic sh…
BackgroundThe management of elderly patients with multiple primary malignant neoplasms (MPMNs) presents a significant clinical challenge, requiring a balance between oncological efficacy and treatment tolerability. This case report details an elderly, …
Most immune checkpoint inhibitors currently used in clinical practice, such as programmed cell death protein 1/programmed death ligand 1 (PD 1/PD L1) inhibitors and cytotoxic T lymphocyte antigen 4 (CTLA 4) inhibitors, are monospecific antibodies actin…
