The transition from menstruation to endometrial regeneration is a dynamic biological interval involving inflammatory resolution, immune-cell regulation, epithelial repair, vascular remodeling, and endocrine-dependent tissue renewal. Although these proc…
Immunotherapy for colorectal cancer (CRC) continues to face significant challenges, particularly in patients with microsatellite stable (MSS) tumors. The cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) pathway is a key regulator of …
This narrative review presents SOIRM as a conceptual and testable research framework rather than a systematic review, a report of new experimental data, or an established treatment model. It distinguishes findings supported by multiple myeloma studies …
Endometriosis is an estrogen-dependent inflammatory disorder that often persists or returns even after visible lesions have been removed. The behavior of peritoneal macrophages may help explain this clinical durability. These cells participate in lesio…
ADAMTS13 is conventionally regarded as the protease whose severe deficiency causes thrombotic thrombocytopenic purpura (TTP). By cleaving shear-unfolded ultra-large and high-molecular-weight von Willebrand factor (VWF), ADAMTS13 limits a platelet- and …
Inflammasomes are multiprotein complexes that orchestrate immune responses to pathogenic and sterile insults by regulating the maturation of inflammatory cytokines and pyroptotic cell death. While inflammasome activation is well-characterized at the bi…
Acute respiratory distress syndrome (ARDS) may remain regionally permeable and poorly reparative after the initiating insult has weakened. We propose that, in a biologically enriched subset of non-resolving ARDS, repeated entry of circulating apolipopr…
Osteoarthritis (OA) is a whole-joint disease involving cartilage, synovium, subchondral bone, and neurovascular structures. Synovitis, damage-associated molecular patterns, and interactions between macrophages and fibroblast-like synoviocytes have been…
Most patients with cancer are older adults living with several other chronic illnesses, and both the tumour and its commonest companions—cardiometabolic disease, type 2 diabetes and depression—are sustained by a shared, immunosuppressive inflammatory m…
Sepsis remains the leading cause of death in intensive care, yet decades of trials targeting individual inflammatory mediators have failed to reduce mortality. This failure may reflect a fundamental misunderstanding: sepsis may not be a disease of immu…
