Lymphovascular invasion (LVI) describes intravasated tumor cells within intratumoral lymphatic or blood vessels. LVI is reported routinely on pathologic examination because it is prognostic for reduced disease-free and overall survival across many soli…
Adult human skin healing is predominantly characterized by fibrosis rather than true regeneration, despite the conserved regenerative principles observed in fetal wound healing, liver regeneration, and other biological systems. Historical and contempor…
Atopic dermatitis (AD) and allergic rhinitis (AR) commonly coexist in childhood and are associated with an important clinical burden. Their frequent coexistence and substantial mechanistic overlap suggest that pediatric AD–AR comorbidity may involve pa…
Rather than viewing classical neurodevelopmental disorders (NDDs) such as autism spectrum disorder (ASD) and severe psychiatric illnesses like schizophrenia (SCZ) as isolated diagnostic silos, modern biological psychiatry increasingly conceptualizes th…
Colorectal cancer (CRC) is a major global health burden, whereas small intestinal cancers are rare despite arising within the same gastrointestinal tract. This disparity suggests that segment-specific epithelial programmes may influence carcinogenesis….
Non-small cell lung cancer (NSCLC) is frequently associated with sarcopenia, a debilitating condition of muscle wasting driven by complex tumor–muscle cross-talk. To unravel the regulatory mechanisms underlying this phenotype, we reconstructed a compre…
BackgroundThree convergent phenomena in biomedical research have lacked a unified mechanistic explanation: the dendritic cell dysfunction of aging, the immune evasion of cancer, and the tolerogenic bias of chronic infection. Each is characterized by fa…
Psoriasis is primarily characterized by interleukin-23/T helper 17 (IL-23/Th17)-related inflammation, but clinical and epidemiological observations also suggest recurrent temporal features, including seasonal fluctuation, nocturnal symptom exacerbation…
Thyroid hormone (TH) signaling is widely recognized as an important regulator of skeletal muscle regeneration, yet the mechanisms by which aging alters TH-dependent regenerative responses remain unresolved. Current models generally assume that age-asso…
Inflammaging is chronic low-grade inflammation arising from a progressive imbalance between pro-inflammatory and anti-inflammatory immune networks. The rate of inflammaging exhibits marked interindividual variation owing to differences in the pace of b…
