BackgroundTezepelumab is a monoclonal antibody that targets thymic stromal lymphopoietin (TSLP). It reduces airway hyperresponsiveness, eosinophilia, mucus plugging, and asthma exacerbations, which are commonly caused by viral infections. Although clin…
BackgroundDry eye disease (DED) is a common multifactorial ocular surface disorder characterized by tear film instability, inflammation, and visual impairment, with rising global prevalence affecting quality of life. While inflammation is central to DE…
BackgroundThe Major Histocompatibility Complex (MHC) is a genomic region present in all vertebrates encoding genes essential for the immune response. In pigs, the MHC is named the Swine Leukocyte Antigen (SLA) complex. Traditional methods for SLA gene…
BackgroundIschemic heart failure (IHF) severely impacts patients’ quality of life and leads to frequent hospitalizations, increased healthcare costs, and increased mortality rates, thus posing a substantial global health challenge. Myocardial ischemia …
BackgroundAfter autologous haematopoietic stem cell transplantation (HSCT), the infused CD34+ cell dose is usually considered essential for assessing the adequacy of the peripheral blood progenitor cells (PBSC) inoculum.MethodsIn a cohort of 302 patien…
ObjectiveTo evaluate the immunogenicity and safety of trivalent inactivated influenza vaccine (IIV3) in adults aged ≥18 years living with HIV and to provide evidence supporting influenza vaccination in this population in China.MethodsThis single-center…
BackgroundEsophageal squamous cell carcinoma (ESCC) is closely linked to chronic inflammation, but the transcriptional mechanisms connecting epithelial inflammatory remodeling with malignant transformation remain incompletely understood.MethodsWe integ…
IntroductionSpatial omic technologies provide insight into molecular architecture and spatial cellular organization within tissue. In rheumatoid arthritis (RA), single-cell RNA sequencing and low-resolution spatial transcriptomics have advanced the und…
The success of germline-targeting vaccines and rational antibody design depends on quantifying the population-level frequencies of specific antibody features, such as CDR lengths, sequence motifs, germline usage or preferred chain pairings, across the …
BackgroundRNA 5-methylcytosine (m5C)-associated programmes may help characterise melanoma cell states and their immune context. We investigated an NSUN5–YBX1–CENPF (NYC) programme using patient-matched sequencing, experimental perturbation and multisca…
