IntroductionHigh-grade gliomas (HGGs) are aggressive primary brain tumors with high recurrence rates and poor prognosis. Survival benefit from adjuvant temozolomide (TMZ) varies substantially across patients, and reliable preoperative biomarkers for tr…
IntroductionEnteropathy is a significant and under-recognised complication of inborn errors of immunity (IEI), frequently misclassified as inflammatory bowel disease (IBD) or coeliac disease due to overlapping and non-specific histopathological finding…
Leishmania infantum is a causative agent of visceral leishmaniasis and survives as an obligate intracellular parasite within macrophages by modulating host cell death pathways. While preservation of host cell viability is critical for parasite replicat…
BackgroundEmerging evidence suggests that oral microbial dysbiosis contributes to neuropsychiatric disorders through microbiome–immune interactions. We previously identified an oral-origin Streptococcus salivarius enriched in individuals with schizophr…
The D−− phenotype is an extremely rare Rh blood group variant with absence of C, c, E, and e antigens but preserved D expression, predisposing to anti-Rh17 alloimmunization and hemolytic disease of fetus and newborn (HDFN). We report a 25-year-old Chin…
IntroductionMyeloid-derived suppressor cells (MDSCs) regulate immune responses, but their role in autoimmune diseases such as rheumatoid arthritis (RA) remains incompletely understood. Here, we applied non-invasive positron emission tomography (PET) im…
BackgroundMetabolic dysfunction-associated steatohepatitis (MASH) can progress to cirrhosis and hepatocellular carcinoma, yet the invasiveness of liver biopsy limits its clinical utility. Accurate noninvasive diagnostic tools are essential for improved…
BackgroundGastric cancer (GC) is often diagnosed at an advanced stage, while endoscopy is invasive and conventional serum tumour markers have limited sensitivity. A low-cost, widely available tool that can identify patients at higher risk and prioritis…
IntroductionRecent research has highlighted the role of gut microbiota in producing bioactive metabolites that interact with G-protein coupled receptors (GPRs) and influence immune responses. Lauroyl tryptamine (LT), a metabolite produced by Agathobact…
BackgroundAdaptive immunity is an ancestral hallmark of jawed vertebrates, yet its genomic organisation is far from static—continually reconfigured through extensive gene family duplication and evolutionary turnover. The major histocompatibility comple…
