BackgroundThe management of patients with severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps requires therapies capable of inducing stable remission. While benralizumab is an established treatment for severe asthma, randomized cont…
IntroductionIntestinal immune barrier integrity is governed by coordinated epithelial renewal, junctional organization, and vesicular trafficking. Herein, we identify a previously undefined role for the noncanonical autophagy protein Rubicon in the mai…
BackgroundPolymyalgia rheumatica (PMR) is an auto-inflammatory disease or autoimmune disease that involves multiple immune cells. In this study, single-cell transcriptome sequencing (scRNA-seq) combined with cellular communication analysis were used to…
BackgroundDefinitive concurrent chemoradiotherapy (dCRT) is standard for locally advanced esophageal squamous cell carcinoma (ESCC), but recurrences remain common. Evidence for consolidation immunotherapy after dCRT is limited. This study evaluated the…
BackgroundImproved risk stratification strategies for neonates and young infants are urgently needed to reduce the substantial mortality burden associated with infectious diseases, particularly in low- and middle-income settings. Evidence supporting th…
IntroductionOvarian cancer ascites creates an immunosuppressive microenvironment that compromises NK cell function, yet the underlying mechanisms remain incompletely understood.MethodsWe used ascites-conditioned NK cells and assessed their mechanopheno…
Multiple sclerosis (MS) is an autoimmune demyelinating disease characterized by neuroinflammation. Toll-like receptor 4 (TLR4) is a receptor for damage-associated molecular patterns, such as high-mobility group box 1 (HMGB1) and plays a role in innate …
BackgroundGammaherpesviruses establish lifelong latency in B cells and are linked to multiple human lymphoid malignancies, including Epstein-Barr virus (EBV)–associated lymphomas that arise at significantly increased frequency in settings of impaired i…
IntroductionAnti–IL-6 therapy with tocilizumab (TCZ) is ineffective in a proportion of patients with idiopathic multicentric Castleman disease (iMCD), particularly the TAFRO subtype, and rescue options remain limited. Evidence for mTOR inhibition comes…
Cell culture relies heavily on serum supplementation, but serum composition makes it difficult to ensure reproducibility and consistency of experimental results. Consequently, research10 groups must test multiple batches to ensure the functionality and…
