BackgroundRenal adverse-event reports during immune checkpoint inhibitor (ICI)–VEGFR tyrosine kinase inhibitor (TKI) therapy may combine immune-interstitial, proteinuric, and nonspecific acute kidney injury (AKI) features. We compared their reporting p…
BackgroundTumor tissues are characterized by high tumor cell turnover, driven by oncogenic proliferation and counteracted by tumor-suppressive mechanisms such as apoptosis and senescence. Dying cancer cells go through apoptosis and release apoptotic pa…
BackgroundKawasaki disease (KD) is an acute systemic vasculitis in children, but the characteristics of the B-cell receptor (BCR) repertoire during acute disease and their association with coronary artery lesions (CALs) remain poorly understood.Methods…
The etiology of pediatric cancer remains poorly understood and does not fit the classical view as an age-associated genetic disease, suggesting yet unknown mechanisms might be involved. Using high-density native proteome arrays, we analyzed sera from 3…
BackgroundTraumatic injury induces rapid systemic immune-inflammatory alterations, but whether routinely measurable admission biomarkers can provide an early biological estimate of anatomical injury burden remains uncertain. This study aimed to charact…
ObjectivesLocalized lymphoid masses of the inferior turbinate with prominent IgG4-positive plasma cell infiltration are occasionally encountered in clinical practice, yet their nature and relationship to IgG4-related disease (IgG4-RD) remain uncertain….
Non-alcoholic fatty liver disease (NAFLD) comprises non-alcoholic fatty liver (NAFL), which rarely progresses, and non-alcoholic steatohepatitis (NASH), which may progress to cirrhosis and hepatocellular carcinoma. Previous studies have shown that Stre…
BackgroundThe limited immune infiltration observed in pancreatic ductal adenocarcinoma (PDAC) is a major factor contributing to immunotherapy resistance and the consistently poor prognosis. Hence, identifying novel therapeutic targets and developing ef…
Dendritic cells (DCs) play a critical role in modulating immune responses and tissue homeostasis. While immature DCs have been shown to enhance cell proliferation, the function of mature DCs (mDCs) in connective tissue biology remains less well underst…
BackgroundChronic radiation proctitis (CRP) represents a significant clinical challenge characterized by irreversible fibrosis and a lack of specific pharmacological interventions. This study aimed to elucidate the cellular mechanisms underlying impair…
