BackgroundGIST tumor microenvironment is characterized by an abundant immune infiltrate. Imatinib exerts immunomodulatory effects that may contribute to a more immunosuppressive microenvironment. Nonetheless, checkpoint inhibitors have demonstrated lim…
IntroductionVenetoclax has transformed the treatment of chronic lymphocytic leukemia (CLL), yet therapeutic resistance remains a major clinical challenge. In addition to leukemia cell-intrinsic mechanisms, interactions with the immune microenvironment …
BackgroundDespite the significant promise of mRNA tumor vaccines in treating solid tumors, their clinical response rate is constrained by the low effectiveness of antigen presentation resulting from the immune-suppressive tumor microenvironment (TME). …
BackgroundOccupational coal dust exposure causes persistent pulmonary inflammation, but the mechanisms by which it may influence thyroid cancer progression remain unclear. Macrophage-derived extracellular vesicles (EVs) may participate in intercellular…
IntroductionImmune cells express vitamin D receptors (VDR) and the CYP27B1 enzyme needed to produce the VDR ligand, 1,25(OH)2D; suggesting that perhaps the vitamin D response is regulated locally at the site of infection. Here, we examined the role of …
BackgroundAs pivotal effector cells of innate immunity, macrophages may play a critical role in immune regulation and fibrotic remodeling in BK polyomavirus nephropathy (BKPyVN) following kidney transplantation. However, their subpopulation heterogenei…
BackgroundPostoperative sepsis arises from a dysregulated host response to infection following surgical stress. Current non-specific biomarkers offer insufficient predictive value, highlighting the need to identify molecular signatures that may facilit…
Background/objectivesTumor infiltrating lymphocytes (TIL) therapy has yielded promising results in melanoma patients, with an approved product available. TIL therapy is of similar interest to a number of additional malignancies, including endometrial c…
BackgroundPeripheral immune-inflammatory dysregulation has been implicated in Alzheimer’s disease (AD) and cognitive decline. However, whether routinely available hematological inflammatory indices are associated with biological and clinical stages acr…
BackgroundAcute Respiratory Distress Syndrome (ARDS) is characterized by alveolar fibrin deposition, driven by dysregulated hypercoagulation and impaired fibrinolysis. Although alveolar epithelial type II (AEC II) cells contribute to this imbalance by …
