BackgroundPrimary mediastinal large B-cell lymphoma (PMBCL) is a highly curable lymphoma in which first-line therapy must balance durable disease control with acute and late treatment toxicity.MethodsWe retrospectively analyzed 98 patients with newly d…
BackgroundGlycosylated RNAs (glycoRNAs) represent a recently recognized connection between RNA biology and cell-surface glycobiology. However, whether glycoRNA-related processes are relevant to human tumors remains unclear, partly because direct glycoR…
IntroductionWe examined whether endometrial quantitative polymerase chain reaction (qPCR) detection of DNA from prespecified pathogen targets classically implicated in chronic endometritis (CE), from other reproductive-tract bacterial targets, or from …
BackgroundBlood–spinal cord barrier (BSCB) disruption and neuroinflammation contribute to secondary injury after spinal cord injury (SCI). Fecal microbiota transplantation (FMT) and human adipose-derived stem cells (hADSCs) each show therapeutic potent…
BackgroundSjogren’s syndrome (SS) is marked by exocrine-gland infiltration and Th17-driven inflammation; low-bioavailability Total glucosides of paeony (TGP) shows efficacy yet unclear mechanisms.PurposeTo investigate the role of intestinal mucosal imm…
IntroductionKirsten rat sarcoma viral oncogene homolog (KRAS)-mutant lung cancer is associated with a poor prognosis, underscoring the need for effective pharmacological treatments. An exploratory subgroup analysis of IMpower150 suggested potential cli…
BackgroundReliable biomarkers for characterization of the risk of severe immune-related adverse events (irAEs) during immune checkpoint inhibition remain lacking. We hypothesized that early dynamics of complementary complete blood count (CBC)-based imm…
Ionizing radiation exposure leads to inflammation and tissue damage, in which macrophage extracellular traps (METs) may play a role. Effective strategies to mitigate inflammation caused by radiation-induced METs are needed. We have recently developed a…
IntroductionAnti-programmed cell death 1 (PD-1)-based neoadjuvant therapy is increasingly used for esophageal squamous cell carcinoma (ESCC), but paired peripheral immune dynamics and their exploratory relationship to response remain incompletely chara…
IntroductionDepression is associated with dysregulation of neuroendocrine, immune, and gut -brain axis pathways. Exercise is an effective non-pharmacological intervention; however, poor motivation and fatigue limit adherence in patients with depression…
