BackgroundPulmonary arterial hypertension (PAH) is a progressive vascular disorder characterized by immune dysregulation and vascular remodeling. Cellular senescence modulates immune responses, but its role in PAH, particularly in monocytes/macrophages…
BackgroundThe combined effects of donor hepatitis B core antibody (anti-HBc) status and recipient pre-transplant hepatitis B surface antibody (anti-HBs) levels on post-transplant HBV events remain unclear in pediatric living donor liver transplantation…
BackgroundHost-directed therapies may improve tuberculosis (TB) outcomes by modulating immune responses and attenuating hyperinflammation, yet accessible biomarkers remain limited. We hypothesized that interferon-γ–inducible protein 10 (IP-10/CXCL10) m…
BackgroundThe impact of environmental antigens, specifically house dust mite (HDM) and Staphylococcus aureus enterotoxin B (SEB), on the metabolism of inflammatory dendritic epidermal cells (IDECs) and its role in atopic dermatitis (AD) pathogenesis is…
BackgroundTriple-negative breast cancer (TNBC) is a heterogeneous disease that often exhibits a relatively immunologically “cold” tumor microenvironment, which can limit the efficacy of immune checkpoint inhibitors (ICIs). Alterations in lipid metaboli…
BackgroundThe Human Phenotype Ontology (HPO) terms for systemic autoinflammatory diseases (SAIDs) were revised in 2022, but their diagnostic accuracy has not yet been validated in real-life cohorts.ObjectivesTo evaluate the diagnostic accuracy of HPO t…
PurposeRheumatoid arthritis (RA) patients face a significantly elevated risk of heart failure (HF), but population-level evidence and underlying mechanisms remain unclear. We aimed to assess the RA-HF association using national data and identify dietar…
Chronic toxoplasmosis begins when tachyzoites cross the blood–brain barrier and enter the Central Nervous System (CNS). There, they differentiate into bradyzoites, which persist in tissue cysts. Here, we investigate changes in host gene expression in t…
ObjectiveAutoimmune hemolytic anemia (AIHA) represents a heterogeneous group of autoimmune disorders, with limited large-scale real-world evidence from Asian populations. This study aimed to characterize the clinical characteristics, treatment patterns…
BackgroundPancreatic cancer is one of the most aggressive and lethal gastrointestinal malignancies, and ferroptosis resistance contributes to chemoresistance. Tumor-educated macrophages(TAMs) are key components of the tumor microenvironment, but whethe…
