BackgroundSerum immunoglobulin reference intervals vary by age, ethnicity, and environment, limiting the clinical utility of international guidelines for Brazilian pediatric patients. This study established age-specific reference intervals for serum Ig…
BackgroundAtopic dermatitis (AD) is a chronic inflammatory skin disorder frequently accompanied by gut dysbiosis and neurobehavioral comorbidities, but the microbial metabolites mediating gut–skin crosstalk remain unclear. We investigated whether preve…
BackgroundChronic inflammatory skin diseases (CISD) affect 20-25% of the population. Psychological stress is considered a modifiable risk factor, yet epidemiologic evidence remains inconsistent, partly due to challenges in capturing stress through clin…
BackgroundT-cell function is regulated by immunometabolism, and lysosomes are signaling hubs. CD68 (LAMP4), traditionally regarded as a monocyte/macrophage marker, has been largely neglected in T cell biology. We aimed to assess the link between CD68 e…
Human monocytes are classified as classical (CD14++CD16−), intermediate (CD14++CD16+), and non-classical (CD14+CD16++) subsets, but CD16 stability during ex vivo assays remains uncertain. Here, we examined whether standard PBMC handling alters CD16-bas…
IntroductionPrenatal opioid exposure (POE) is an escalating public health concern. However, its impact on neonatal immune development remains poorly defined. This study examined how POE, with or without maternal hepatitis C (hepatitis C virus, HCV) inf…
IntroductionLyme arthritis (LA) involves complex immune dysregulation, and macrophages contribute centrally to persistent joint inflammation. However, synovial macrophage heterogeneity and its potential relevance to therapeutic intervention remain inco…
IntroductionFulfilling a vision that extends beyond their role as antibiotic alternatives, bacteriophages are now recognized as active immunomodulators, a concept aligning with early hypotheses of their biological activity. In addition to their bacteri…
ObjectiveThe use of tacrolimus (TAC) in ocular myasthenia gravis (OMG) is generally reserved for cases refractory to prednisone (PRED); however, the advantage of monotherapy with tacrolimus (mono-TAC) over monotherapy with PRED (mono-PRED) remains unkn…
BackgroundNeuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune inflammatory disease for which reliable biomarkers of disease activity are lacking. Meteorin-like protein (Metrnl) has not been investigated in NMOSD; this study assessed i…
