IntroductionOral squamous cell carcinoma (OSCC) is characterized by inter- and intratumoral heterogeneity, which complicates patient stratification and treatment. Although single-cell studies have improved the resolution of the OSCC microenvironment, t…
Cancer-associated fibroblasts (CAFs) are key regulators of the tumor microenvironment; however, their role in modulating neutrophil function during cervical cancer (CC) progression remains poorly understood. In this study, we evaluated whether CAF supe…
BackgroundPsoriasis is a chronic systemic inflammatory disease that imposes a considerable burden of metabolic comorbidities. Metabolic dysfunction-associated steatotic liver disease (MASLD) is particularly common among patients with psoriasis, which m…
IntroductionSevere dengue infection is characterized by endothelial injury and systemic inflammatory complications. To better understand the mechanisms underlying disease severity, we investigated a broad panel of circulating inflammatory and endotheli…
BackgroundIntrahepatic cholangiocarcinoma (ICC) exhibits substantial cellular heterogeneity and a complex tumor microenvironment (TME), contributing to poor clinical outcomes. Effective prognostic biomarkers and a deeper understanding of the cellular e…
BackgroundH5N1 highly pathogenic avian influenza (HPAI) has been detected in multiple animal species, including humans, posing a significant threat to public health. Vaccines capable of eliciting robust mucosal and systemic immunity are needed to prote…
BackgroundPneumonia is the second most common infection in individuals with end-stage kidney disease and is associated with poor prognosis. The most frequently implicated pathogen is Streptococcus pneumoniae. Vaccine coverage is therefore essential. Di…
RationalSteroid-insensitive type 2 cytokine-producing CD8+ T cells (Tc2) are enriched in patients with severe asthma and correlate with disease severity, highlighting their potential role as drivers of treatment-refractory disease. The molecular mechan…
IntroductionAdult autoimmune neutropenia (AIN) is a rare and probably underrecognized immune cytopenia for which population-based adult incidence estimates are not established. Unlike the benign, self-limiting course seen in children, the adult traject…
BackgroundAutoimmune cerebellar ataxia (ACA) can cause substantial disability. Evidence regarding immunotherapy for ACA, including rituximab (RTX), remains limited. This study evaluated the association of RTX treatment with outcomes in nonparaneoplasti…
