IntroductionHuman cytomegalovirus (CMV) is the leading infectious cause of congenital birth defects worldwide. The placenta is a major route of vertical transmission, and both immune and trophoblast cells are susceptible to CMV infection. This study ai…
BackgroundTo investigate the clinical characteristics and factors for pulmonary embolism (PE) in children with severe Mycoplasma pneumoniae pneumonia (SMPP).MethodsThis retrospective study included pediatric patients with SMPP hospitalized at the Affil…
ObjectiveTo describe the clinical characteristics of infusion-related reactions (IRRs) associated with cadonilimab in a real-world cohort and propose preliminary management considerations based on these observations.MethodsA descriptive retrospective c…
Severe fever with thrombocytopenia syndrome (SFTS), caused by Dabie bandavirus, is associated with high mortality among intensive care unit (ICU) patients; however, the integrated proteomic–metabolomic mechanisms underlying fatal outcomes remain poorly…
IntroductionWhile biologic disease-modifying antirheumatic drugs (bDMARDs) have transformed management, achieving complete remission remains a challenge due to complex immune networks in Psoriatic arthritis (PsA). This study aimed to characterize the f…
IntroductionSalmonella infection remains a pervasive diarrheal illness, particularly affecting populations in developing countries. The lack of an effective vaccine against non-typhoidal Salmonella is attributable to antigenic diversity among serotypes…
BackgroundOsteoarthritis (OA) is increasingly recognized as a whole-joint disorder in which mechanical stress, cellular mechanosensing, and inflammatory responses interact across joint tissues. Although OA mechanoinflammation has attracted growing atte…
Circulating T follicular regulatory (cTfr) cells are measured as blood biomarkers after vaccination, in autoimmune disease (e.g., lupus, rheumatoid arthritis) and cancer immunotherapy, yet whether they originate from natural Tregs (yielding nTfr) or ge…
BackgroundAcute graft-versus-host disease (aGVHD) remains a leading cause of non-relapse mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The lactate dehydrogenase-to-albumin ratio (LAR), integrating metabolic stress and …
BackgroundUlcerative colitis (UC) is reported with medications from different therapeutic classes. We examined these reporting associations together with recorded clinical context and tested whether experimental cytokine-blockade signatures align with …
