Probiotics are widely recognized for their ability to promote gut health, modulate immunity, and reduce oxidative stress. As an emerging probiotic within the genus Weissella, Weissella koreensis (WK) exhibits promising immunomodulatory potential. Recen…
BackgroundPolycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental toxicants, yet the toxicological mechanisms by which they induce idiopathic pulmonary fibrosis (IPF) remain poorly understood. This study aims to systematically elucidate th…
IntroductionThe optimal frontline treatment option for Peripheral T-cell lymphomas (PTCLs) has not been completely defined.MethodsTo compare the efficacy and safety of brentuximab vedotin (BV) combined with CHP-like regimen (cyclophosphamide, an anthra…
Scientific problemStudying the acute, cell-intrinsic functions of signaling proteins in T cells has long been challenging. Existing constitutive or inducible gene deletion cannot overcome developmental adaptation that obscures true phenotypes. Similarl…
BackgroundLangerhans cell histiocytosis (LCH) is a rare pediatric disease with marked clinical heterogeneity. Current risk stratification relies on the extent of organ involvement and risk-organ status, yet reliable protein biomarkers for distinguishin…
ObjectiveReliable biomarkers for early interstitial lung disease (ILD) risk stratification are limited; therefore, we aimed to identify prediagnostic proteins associated with incident ILD and develop a long-term prediction model.MethodsWe analyzed 52,7…
IntroductionType 1 diabetes (T1D) is an autoimmune disease characterized by progressive pancreatic β-cell destruction, yet molecular features distinguishing it from other autoimmune conditions in early life remain poorly defined. We previously identifi…
BackgroundLong-term monitoring of chimeric antigen receptor T-cell (CAR-T) persistence is essential for assessing therapeutic efficacy, particularly when circulating CAR-T cell levels decline following infusion. Although quantitative real-time PCR (qPC…
IntroductionThe envelope (Env) glycoproteins derived from circulating viruses in elite-neutralizers (ENs), who naturally develop potent broadly neutralizing antibody (bnAb) responses, serve as a potential template for HIV-1 vaccine design. Here, we inv…
BackgroundGastrointestinal (GI) bleeding represents a severe complication of IgA vasculitis (IgAV). Most current analyses of risk factors aggregate patients across all ages, potentially obscuring critical age-specific differences. This study aimed to d…
