ObjectiveThis study aimed to analyze clinical and immunological characteristics in patients with rheumatoid arthritis (RA) according to bone loss status, integrate traditional risk factors with immune-inflammatory indicators, and construct and validate…
Human papillomavirus (HPV), the major cause of cervical cancer, continues to be associated with an increasing number of diagnosed cases despite the availability of licensed vaccines such as Cervarix™ and GARDASIL®. In addition, cervical cancer incidenc…
Background and objectivesAccurate prognostic assessment of acute-on-chronic liver failure (ACLF) remains a major clinical challenge. Existing models, such as the Model for End-Stage Liver Disease (MELD), rely solely on clinical indicators and do not in…
AAV gene therapy is a promising approach for long-term delivery of antiviral proteins that can control HIV replication, but pre-existing circulating AAV-specific antibodies can preclude successful AAV transduction and pose a challenge for AAV vector re…
BackgroundAnoikis resistance enables tumor cells detached from the extracellular matrix to survive during metastatic dissemination, yet its relationship with the immune microenvironment of hepatocellular carcinoma (HCC) remains incompletely understood….
PurposeLncRNA MEG3 and miR-144-3p have been confirmed to be related to ocular pathological processes, but their roles as early diagnostic biomarkers for Primary open angle glaucoma (POAG) and the underlying regulatory mechanisms remain unclear.MethodsT…
BackgroundPrimary non-response (PNR) to infliximab (IFX) remains a major therapeutic challenge in ulcerative colitis (UC). However, the molecular mechanisms underlying this treatment failure remains unelucidated. Therefore, there is an urgent need to i…
BackgroundPsoriatic arthritis (PsA) and rheumatoid arthritis (RA) may present with overlapping hand and wrist symptoms, while their anatomical patterns of inflammation differ.ObjectiveTo compare prespecified hand and wrist magnetic resonance imaging (M…
IntroductionPresent therapies for ulcerative colitis (UC) frequently encounter challenges due to medication resistance and side effects, underscoring the necessity to discover secure and efficacious therapeutic targets. Clarithromycin (CLA), a macrolid…
BackgroundDysregulated buildup of extracellular matrix constitutes a hallmark of hepatic fibrosis, loss of liver architectural integrity, and impaired hepatic functional capacity. Pro-fibrogenic M2-polarized macrophages promote the transdifferentiation…
