Background and objectiveChronic inflammation in persons with (PWH) and without HIV (PWoH) is linked to cardiovascular disease (CVD). The fat attenuation index (FAI), a marker of peri-coronary inflammation, predicts CVD risk. The relationship between FA…
BackgroundUrethral strictures are characterized by fibrotic scar tissue formation in the urethra, leading to difficulties in urination and potential renal dysfunction. The cellular microenvironment contributes to stenosis. However, the heterogeneity of…
BackgroundAcute myocardial infarction (AMI) followed by reperfusion result in a phasic response by cardiac macrophages. During the first 7 days after AMI, macrophage populations exhibit dynamic phenotypic changes. Ultimately, inflammatory damage result…
BackgroundSystemic lupus erythematosus-associated myelitis (SLE-AM) is a devastating neuroimmunological complication. Increasing evidence suggests that myelitis occurring in patients with SLE is heterogeneous and may include non-overlap SLE-AM and SLE-…
BackgroundMicroscopic polyangiitis (MPA) remains associated with substantial early mortality despite advances in immunosuppressive therapy, highlighting the need for simple biomarkers that facilitate LR) has been associated with disease activity and pr…
BackgroundC3 glomerulopathy (C3G) is a chronic kidney disease previously included within the broader spectrum of membranoproliferative glomerulonephritis. Information on various aspects of C3G, including epidemiology, management, and patient needs, is …
BackgroundAxial spondyloarthritis (axSpA) assessment on MRI is complicated by interpretation difficulty and by clinical variables that may be incomplete at the time of imaging. We aimed to develop an image-only deep learning framework to approximate th…
IntroductionSepsis-associated acute lung injury (SALI) is a life-threatening pulmonary complication of sepsis with high mortality. This study aimed to prioritize serum metabolites and genes potentially involved in SALI by integrating multi-omics datase…
Surgical resection of cartilage-infiltrating head and neck squamous cell carcinoma (HNSCC) frequently results in significant tissue defects, which require reconstructive interventions. Orthotopic reimplantation of autologous laryngeal cartilage tissue …
IntroductionDendritic cells (DCs) are pivotal orchestrators of immune activation, serving as professional antigen-presenting cells that bridge innate and adaptive immunity. Among them, conventional type 1 dendritic cells (cDC1s) play a critical role in…
