IntroductionIn relapsing-remitting multiple sclerosis (RRMS) it is challenging to predict which person will benefit from a certain therapy, such as cladribine tablets (CladT). This study aimed to obtain a better understanding of the interaction between…
IntroductionThe gut microbiota is associated with host development and endocrine signaling, but its role in early zebrafish development remains incompletely understood. Germ-free (GF) fish models are powerful tools to reveal the functions of intestinal…
IntroductionLong COVID (LC) is characterized by persistent and, often, disabling symptoms, yet its biological basis remains unclear. Multiple mechanisms, including immune dysregulation, endothelial dysfunction, and persistence of SARS-CoV-2 components,…
BackgroundTendinopathy is frequently associated with chronic inflammation driven by pro-inflammatory cytokines. Among these, interleukin-1β (IL-1β) serves as a central mediator of tendon degradation, yet its genome-scale transcriptional and epigenetic …
BackgroundThe leukemia inhibitory factor receptor (LIFR) is a key signaling receptor within the IL-6 cytokine-family, and its integrity is essential for STAT3 and ERK activation in developmental and immune pathways. Recessive, predominantly truncating …
BackgroundPreterm birth is a primary risk factor for long-term neurodevelopmental deficits. While acute neonatal inflammation is a known disruptor of brain development, the persistence of immune dysregulation and its relationship with body composition …
BackgroundSepsis-associated cognitive impairment (SACI) is a frequent long-term complication of sepsis characterized by hippocampal neuroinflammation, synaptic loss and gut microbial dysbiosis. Akkermansia muciniphila (AKK) possesses anti-inflammatory …
Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are inflammatory autoimmune diseases of the central nervous system (CNS) that share demyelinating features but differ fundamentally in pathogenesis. The discovery of neuromyelit…
IntroductionSeveral studies have examined human exposure to ultrafine particulate matter (UFPM), Black carbon (BC), and polystyrene nanoplastics (PS-NPs). However, it remains unclear whether different chemical types of environmental nanoparticles induc…
Cancer-testis antigens (CTAs) are attractive targets for tumour immunotherapy due to their restricted expression in human malignancies and broad population-level prevalence. However, naturally occurring CTA-reactive T cells are often exhausted or funct…
