BackgroundExercise, habitual physical activity, and physical fitness have been proposed as behavioral adjuvants that could improve influenza vaccine immunogenicity, but individual studies are small and inconsistent.ObjectiveTo evaluate the effects of a…
BackgroundOptimal second-line systemic therapy for advanced hepatocellular carcinoma (HCC) remains uncertain. This study compared the efficacy and safety of available second-line treatments after tyrosine kinase inhibitor (TKI) failure and explored tre…
Pemphigus is an autoimmune blistering disease affecting both the skin and mucous membranes, causing secondary infections and high mortality. Micronutrients are important factors influencing the health of oral mucosa. It has been reported that patients …
BackgroundAutoimmune encephalitis (AE) is an immune-mediated inflammatory disorder of the central nervous system associated with substantial morbidity. Acute-phase immunotherapy is crucial for improving outcomes, yet the comparative efficacy and safety…
BackgroundAdults living with HIV may have persistent immune activation and low-grade inflammation despite effective antiretroviral therapy. We assessed whether resistance training or resistance-containing combined exercise alters inflammatory biomarker…
ObjectiveAntibody–drug conjugates (ADCs) are being investigated in advanced small-cell lung cancer (SCLC), but the evidence is dominated by early-phase studies conducted in non-exchangeable treatment settings. We evaluated the activity and toxicity of …
BackgroundNeuronal antibodies detected during evaluation of rapidly progressive dementia may indicate treatable autoimmune encephalitis or incidental seroreactivity in prion disease. We estimated their frequency in sporadic Creutzfeldt-Jakob disease (s…
IntroductionVitiligo is a chronic autoimmune depigmentation skin disorder characterized by the acquired loss of melanocytes, with a complex multifactorial pathophysiology. Among the potential predisposing factors, some drugs, including monoclonal antib…
BackgroundMultiple RCTs have established PD-1/PD-L1 inhibitors as standard in triple-negative breast cancer (TNBC), but prior meta-analyses lacked complete setting coverage, mature long-term survival data, and a quantification of chemotherapy-backbone …
BackgroundSystemic sclerosis (SSc) is a complex autoimmune disease mainly characterized by progressive fibrosis affecting the skin and internal organs. Although several immunosuppressive and targeted therapies are currently available, many patients con…
