Sepsis is a heterogeneous, time-dependent syndrome in which inflammatory injury, immune suppression, endothelial dysfunction, metabolic disturbance, and barrier failure may coexist. This narrative review evaluates whether current pharmacological eviden…
BackgroundOsteoarthritis (OA) is increasingly understood as a whole-joint organ disease involving cartilage, synovium, subchondral bone, and the local immune-stromal microenvironment. Synovial fibroblasts and fibroblast-like synoviocytes (FLS) particip…
BackgroundA growing number of studies have indicated that traditional Chinese medicine (TCM) can regulate microbiota in chronic inflammatory airway disease (CIAD). Nevertheless, no systematic review or integrated analysis has summarized relevant eviden…
BackgroundThrombotic microangiopathy (TMA) complicating systemic lupus erythematosus (SLE) and lupus nephritis (LN) spans immune thrombotic thrombocytopenic purpura, anti-phospholipid-associated microangiopathy, secondary endothelial injury, and comple…
ObjectiveThis study aimed to systematically evaluate the efficacy of first-line immune checkpoint inhibitors (ICIs) combined with targeted therapy for advanced renal cell carcinoma (RCC) and assess their cost-effectiveness from the perspective of the C…
BackgroundImmune checkpoint inhibitor-associated inflammatory arthritis (ICI-IA) and polymyalgia rheumatica (PMR)-like syndromes are clinically important rheumatic immune-related adverse events, but definitions vary across studies. We estimated their o…
BackgroundPatients with relapsed/refractory multiple myeloma (RRMM) experience poor outcomes following multiple lines of therapy. Available evidence has largely pooled disparate immunotherapy platforms. The present systematic review and meta-analysis w…
BackgroundLatent tuberculosis infection (LTBI) affects nearly a quarter of the world’s population, yet current diagnostic tools are suboptimal. Interferon-γ-inducible protein 10 (IP-10) has been proposed as a candidate biomarker, but its diagnostic val…
BackgroundImmune checkpoint inhibitor (ICI)-based neoadjuvant/perioperative strategies are expanding for locally advanced resectable gastric/gastroesophageal junction (G/GEJ) adenocarcinoma, but the evidence base differs substantially across strategies…
ObjectivesTo identify prognostic factors independently associated with poor renal outcomes in childhood-onset lupus nephritis (cLN) based on multivariable analyses.MethodsSeven databases were searched up until October 2025. Adjusted odds ratio (OR), ha…
