BackgroundElevated Neutrophil extracellular traps (NETs) associated biomarkers have been documented in inflammatory bowel disease (IBD) patients and preclinical models, but the therapeutic potential of targeting NETs remains unclear. This systematic re…
BackgroundKnee osteoarthritis (KOA) has traditionally been regarded as a localized degenerative joint disorder; however, accumulating evidence increasingly supports a critical role for immunometabolic dysfunction, chronic low-grade inflammation, and sy…
Mycobacterium avium subsp. paratuberculosis (MAP) is the primary causative agent of Johne’s disease (JD) in ruminants and bears potential public-health implications. Cumulative epidemiological and molecular evidence implies MAP may contribute to Crohn’…
BackgroundLocalized scleroderma (LoS) is an autoimmune disorder leading to skin sclerosis and subcutaneous tissue atrophy. Apart from the disfiguring craniofacial lesions, the extracutaneous involvement in LoS has been increasingly recognized and studi…
BackgroundGout is an inflammatory arthritis characterized by hyperuricemia in humans. Male patients with gout or hyperuricemia have a wide range of reproductive health challenges. However, research on the sexual and reproductive health of male patients…
BackgroundChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) management is undergoing a paradigm shift with the emergence of targeted biologicals. We aimed to compare the efficacy, safety, and functional outcomes of neonatal Fc receptor (…
BackgroundTumor necrosis factor-α inhibitors (anti-TNF-α) and mesenchymal stem cells (MSCs) have been proven to be effective for Perianal fistulizing Crohn’s disease (PFCD). However, no head-to-head clinical trials have directly comparing these two the…
BackgroundB cells play a critical role in autoimmunity through autoantibody production, plasma cell differentiation, antigen presentation, cytokine secretion, and germinal center responses. The clinical efficacy, durability, and safety profiles vary ac…
BackgroundBreast cancer (BC) is the most common malignant tumor among women worldwide. Radiotherapy (RT) is a primary treatment modality; however, local recurrence driven by radioresistance frequently undermines its efficacy.MechanismsGrowing evidence …
BackgroundThis study evaluates the quality of study design, potential biases, and evidence strength for childhood risk factors associated with allergic rhinitis (AR), while summarizing the key identified factors.MethodsThe protocol for this review was …
