ObjectiveChronic inducible urticaria (CIndU) affects approximately 0.5% of the population and is characterized by wheals triggered by specific stimuli, such as cold or heat exposure, physical exertion, mechanical friction, vibration, or delayed pressur…
Background/purposeAtezolizumab–bevacizumab (AB) and durvalumab–tremelimumab (DT) are standard first-line therapies for unresectable hepatocellular carcinoma (uHCC), but their comparative effectiveness remains uncertain.MethodsWe included 76 observation…
BackgroundThe role of adjuvant immunotherapy after neoadjuvant therapy and esophagectomy remains uncertain. We examined its association with survival in populations composed predominantly of patients with residual disease across neoadjuvant strategies….
BackgroundThe safety of biological agents in the treatment of rheumatoid arthritis (RA) is an important factor affecting patient prognosis and treatment adherence. Among them, interleukin inhibitors are an important category. However, the safety of dif…
BackgroundHypoxia, cancer stem cell (CSC) plasticity, and immune suppression are established features of the tumor microenvironment, but their integration within the same biological systems has not been comprehensively synthesized. This systematic revi…
BackgroundImmune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) across multiple organs. High-throughput omics approaches may help characterize susceptibility, molecular mechanisms, diagnostic features, and monitoring marke…
BackgroundHypoxia, cancer stem cell (CSC) plasticity, and immune suppression are established features of the tumor microenvironment, but their integration within the same biological systems has not been comprehensively synthesized. This systematic revi…
BackgroundSepsis represents a life-threatening dysregulation of the host inflammatory response, progressing from innate immune hyperactivation and pro-inflammatory cytokine release to a secondary immunosuppressive phase. Although the diagnostic framewo…
Introduction and aimsOral mucositis (OM) impairs quality of life, necessitates dose modification, and disrupts treatment continuity in patients receiving EGFR tyrosine kinase inhibitors (EGFR-TKIs), yet comparative OM risks across monotherapies and com…
ObjectiveTo systematically evaluate the efficacy and safety of thymosin α1 combined with chemotherapy in the treatment of gastric cancer.MethodsA systematic search of 8 electronic databases was conducted to identify relevant RCTs. Meta-analysis was per…
