Shuai Wang IntroductionAnkylosing spondylitis (AS) is a chronic inflammatory disorder with poorly defined pathogenic mechanisms. The integrated stress response (ISR), an evolutionarily conserved signaling network, is implicated in AS development. This research en…
This article reports a case of SAPHO syndrome misdiagnosed as spinal infection, detailing the clinical manifestations, laboratory tests, and imaging features of the patient. Through a review of the literature, common confounding factors and reasons for…
Extracellular vesicles (EVs) are lipid membrane-bound vesicles involved in cell-cell communication, particularly in the context of cancer. Immunotherapy, a rapidly evolving field in oncology, is a type of cancer treatment relying on the body’s own immu…
Triggering receptor expressed on myeloid cells-2 (TREM2) is a transmembrane immune receptor that is expressed mainly on macrophages. As a pathology-induced immune signaling hub, TREM2 senses tissue damage and activates immune remodeling in response. Pr…
Cellular & Molecular Immunology, Published online: 19 September 2024; doi:10.1038/s41423-024-01215-0Hepatocellular carcinoma-specific epigenetic checkpoints bidirectionally regulate the antitumor immunity of CD4 + T cells
