IntroductionType 1 diabetes (T1D) is an autoimmune disease characterized by progressive pancreatic β-cell destruction, yet molecular features distinguishing it from other autoimmune conditions in early life remain poorly defined. We previously identifi…
Brain-computer interfaces (BCIs) have made significant progress in fields such as neurorehabilitation, motor reconstruction, and alternative communication by capturing, decoding, and providing feedback on brain activity. In contrast, the application of…
BackgroundLong-term monitoring of chimeric antigen receptor T-cell (CAR-T) persistence is essential for assessing therapeutic efficacy, particularly when circulating CAR-T cell levels decline following infusion. Although quantitative real-time PCR (qPC…
Intravenous thrombolysis and mechanical thrombectomy have transformed acute ischemic stroke (AIS) care, yet angiographic recanalization does not guarantee adequate tissue reperfusion or long-term functional independence. Brain cytoprotection has theref…
IntroductionThe envelope (Env) glycoproteins derived from circulating viruses in elite-neutralizers (ENs), who naturally develop potent broadly neutralizing antibody (bnAb) responses, serve as a potential template for HIV-1 vaccine design. Here, we inv…
N6-methyladenosine (m6A) represents the most prevalent modification on eukaryotic RNA and plays a critical role in nearly all stages of RNA expression regulation. Extensive research demonstrates that the dysregulation of m6A modification plays a signif…
BackgroundBladder urothelial carcinoma (BUC) exhibits high recurrence and poor prognosis, with limited efficacy of current immunotherapies. The role of the aggrephagy-related gene TUBA1A in the BUC immune microenvironment remains unclear.MethodsSingle-…
BackgroundGastrointestinal (GI) bleeding represents a severe complication of IgA vasculitis (IgAV). Most current analyses of risk factors aggregate patients across all ages, potentially obscuring critical age-specific differences. This study aimed to d…
Severe pneumonia-associated lung injury is a major cause of acute respiratory failure, acute respiratory distress syndrome (ARDS), and death in critically ill patients. Its course is shaped within the critically ill host environment by pulmonary infect…
BackgroundBrucellosis can resemble lymphoma when lymphadenopathy accompanies cytopenias and systemic inflammation. Associated secondary haemophagocytic lymphohistiocytosis (HLH) adds to the diagnostic difficulty.Case presentationA 68-year-old man prese…
