Lin Zhang Osteoarthritis is a whole-joint disease involving articular cartilage, synovium, subchondral bone, fat pad, meniscus, blood vessels, and sensory nerves. Its core pathology is not simply passive wear of the cartilage matrix, but rather reciprocal drivin…
ObjectiveThis study aims to evaluate the prevalence, clinical characteristics, severity, mortality, and outcomes of COVID-19 infection in heart transplant recipients, focusing on risk factors for severe disease.MethodsA retrospective, observational stu…
Myeloid leukemia (ML) is a clonal malignant disease with abnormal hematopoietic stem cells. With the emergence of novel immunotherapies, such as CAR-T, therapeutic outcomes in ML patients have improved, while significant challenges persist, including s…
BackgroundFine particulate matter (PM2.5) exposure has been associated with adverse effects on reproduction, yet the underlying cellular mechanisms remain poorly understood.MethodsUsing single-cell RNA sequencing, we systematically investigated cell cy…
Pediatric osteosarcoma, the most prevalent primary malignant bone tumor in children, is marked by aggressive progression and a generally poor prognosis. Despite advances in treatment, including multi-agent chemotherapy, survival rates remain suboptimal…
