BackgroundChronic radiation proctitis (CRP) represents a significant clinical challenge characterized by irreversible fibrosis and a lack of specific pharmacological interventions. This study aimed to elucidate the cellular mechanisms underlying impair…
BackgroundHepatocellular carcinoma (HCC) carries a high recurrence risk after curative resection, yet effective adjuvant strategies remain lacking. Although donafenib plus anti-PD-1 monoclonal antibodies has shown efficacy in advanced HCC, the effectiv…
BackgroundMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Recent work indicates that bone-marrow hematopoietic niches sense CNS autoimmunity and enhance myeloid output. However, whether MS bone mar…
IntroductionPregnancy-specific glycoprotein 9 (PSG9) is one of 10 members of a conserved glycoprotein family within the carcinoembryonic antigen superfamily expressed by placental trophoblasts and secreted into maternal circulation. PSG1 and PSG9 induc…
IntroductionSepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection; its early diagnosis and mortality prediction remain challenging, and conventional markers (CRP, PCT) have limited sensitivity and specificit…
Dengvaxia® induces antibody responses in dengue virus (DENV)-naïve children, but the durability of these responses and their impact on subsequent wild-type (WT) DENV infection remain unclear. Although previous studies have primarily evaluated vaccine e…
Periodontitis is a dysbiotic inflammatory disease characterized by progressive periodontal destruction, in which neutrophils play a central but functionally diverse role. IL-17A is closely linked to neutrophil-mediated host responses; however, how IL-1…
Glioma remains largely refractory to immune-checkpoint blockade, in part because tumor-intrinsic mechanisms sustain programmed death-ligand 1 (PD-L1) and reinforce an immunosuppressive microenvironment. Tripartite motif-containing 14 (TRIM14) is an imm…
IntroductionCystic echinococcosis (CE) is a zoonotic parasitic disease caused by Echinococcus granulosus, and the T and B cell responses and regulatory mechanisms in CE remain unclear.MethodsIn this study, we analyzed the data of peripheral blood and s…
BackgroundMultiple sclerosis (MS) disease-modifying therapies (DMTs) alter host immunity and may produce pathogen-specific susceptibility to neuroinvasive infection. Comparative evidence is limited because events are rare and postmarketing research foc…
