Genomic instability and immune escape are linked features of hematologic malignancies, but the mechanisms that allow malignant cells to tolerate persistent nuclear and genotoxic stress while avoiding damaging DNA-sensing responses remain incompletely d…
Bronchopulmonary dysplasia (BPD), the most common chronic lung disease of prematurity, is at its mechanistic core an immune-developmental disease in which inflammatory injury disrupts normal lung maturation. In the United States, BPD remains among the …
Burns constitute a form of severe trauma and may affect multi-organ systems. Secondary multi-organ dysfunction is the primary driver of disability, death, and poor prognosis in patients with severe burns, and has become a pressing global public health …
Chronic inflammatory diseases remain a major global health burden, with approximately 30–40% of patients responding inadequately to current cytokine-targeted biologics, Janus kinase (JAK) inhibitors, or small-molecule immunomodulators. Beyond suboptima…
Benign prostatic hyperplasia (BPH) is a common chronic and progressive disease in ageing men. Its pathobiology involves androgen-signaling remodeling, chronic inflammation, oxidative stress, metabolic disturbance, and dysregulated cell fate control; ho…
Obstructive sleep apnea (OSA) is characterized by recurrent upper airway obstruction during sleep. Its hallmark pathophysiological features, intermittent hypoxia (IH) and sleep fragmentation (SF), trigger cellular and molecular responses that disrupt i…
Polyendocrine metabolic ovarian syndrome (PMOS) is a prevalent endocrine-metabolic disorder characterised by follicular arrest, anovulation, and elevated androgen levels. This review transcends single-dimensional analyses of PMOS pathology from neuroen…
Congenital transmission of Zika virus (ZIKV) and Trypanosoma cruzi (T. cruzi) remains a major public health concern in the Americas. Both pathogens cross the placental barrier and cause severe neonatal outcomes, yet no confirmed congenital co-infection…
Deep brain stimulation (DBS) is an established symptomatic therapy for Parkinson’s disease (PD), yet its biological effects extend beyond modulation of abnormal basal ganglia circuitry. This review conceptualizes DBS in PD as a neuroimmune-metabolic in…
Multiple sclerosis (MS) is an immune-mediated neurodegenerative disease where chronological aging predicts the conversion to progressive MS (PMS), a phase defined by compartmentalized inflammation and accelerated neurodegeneration. While current diseas…
