Immunological memory is a core feature of the immune system that enables rapid and robust responses to re-exposure to the same antigens, underpinning durable antitumor immunity and the efficacy of cancer immunotherapy. However, the epigenetic mechanism…
Intensive livestock production depends critically on vaccination, yet the licensed veterinary adjuvant repertoire remains narrow, being dominated by aluminium salts and mineral-oil emulsions that offer limited control over response quality and cause in…
Microbial metabolites can suppress or promote tumor development and modify treatment response, but the direction of an effect depends on its chemical identity, anatomical source, concentration and host target. This narrative review critically examines …
C-reactive protein (CRP) is a crucial biomarker of inflammation and a primary pattern recognition molecule of the innate immune system. It is predominantly synthesized by hepatocytes and subsequently released into the circulation. The concentration of …
Tumor antigens provide the molecular interface between malignant transformation and host immunity, but their biological significance is determined by more than their molecular existence. Antigen clonality, abundance, processing, human leukocyte antigen…
BackgroundTebentafusp improves survival in HLA-A*02:01-positive metastatic uveal melanoma, yet the human evidence linking early systemic immune activation to remodeling of metastatic tumors is dispersed across overlapping translational reports.MethodsW…
Acute kidney injury (AKI) and chronic kidney disease (CKD) are common clinical disorders that have high incidence and mortality. Their pathogenesis and the mechanisms underlying AKI-to-CKD progression remain unclear. Metabolic reprogramming has emerged…
The “microbiota-gut-brain axis” represents a critical link connecting various aspects of intestinal physiology, brain function, and behavioral performance. Among these, tryptophan metabolism abnormalities mediated by gut microbes through the gut-brain …
Chemokine–receptor axes are traditionally viewed as leukocyte trafficking cues, but increasing evidence indicates that they also function as spatial and functional organizers of immune–tumor communication. In the tumor microenvironment, chemokine gradi…
Acute lung injury (ALI, a term widely used in preclinical animal studies, while the clinical definition of ALI was eliminated in the Berlin criteria) and its severe human clinical counterpart, acute respiratory distress syndrome (ARDS), constitute life…
