Rosacea is a chronic inflammatory skin disease that primarily affects the central facial region, including the cheeks, nose, chin, and forehead. Its clinical features include episodic flushing, persistent erythema, telangiectasia, papulopustular lesion…
Regulatory T cells (Tregs) are essential for enforcing immune tolerance and homeostasis, but they comprise several distinct populations that differ in developmental origin, activation state, tissue adaptation, and functional specialization. These diffe…
Inflammation following myocardial infarction (MI) is a key determinant of patient prognosis; however, existing anti-inflammatory strategies remain limited in terms of overall benefit, patient eligibility, and safety, creating an urgent need for the dev…
Glioblastoma, IDH-wildtype, CNS WHO grade 4 (GBM) is the most aggressive primary malignant brain tumor in adults, with a median overall survival of approximately 15 months despite maximal surgical resection, radiotherapy, and chemotherapy with temozolo…
Chimeric Antigen Receptor T (CAR-T) cell therapy has emerged as a promising therapeutic option, particularly for refractory and relapsed leukemias. However, its efficacy in treating solid tumors, including lung, ovarian, gastric, and breast cancers, re…
Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant primary brain malignancies, with limited improvement in long-term survival despite advances in multimodal therapy. Glioblastoma stem cells (GSCs) are central to tumour initia…
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most challenging malignancies due to profound biological heterogeneity, complex stromal organization, and limited responsiveness to current immunotherapies. Recent advances in single-cell seque…
Antibody-drug conjugates (ADCs) have progressively advanced the conceptual framework of targeted oncology, evolving from a way to deliver chemotherapy selectively to tumor cells into drugs that also interact with the immune system to support their acti…
Immunoglobulin A nephropathy (IgAN), defined by mesangial immune-complex deposition enriched for galactose-deficient IgA1 (Gd-IgA1), is the most prevalent biopsy-confirmed primary glomerulonephritis worldwide. Advances in mucosal immunobiology and gene…
Laryngeal squamous cell carcinoma (LSCC) is a common malignancy of the head and neck, accounting for the vast majority of laryngeal cancers. Its development involves complex interactions between genetic and epigenetic alterations. Histone post-translat…
