Traumatic hemorrhagic shock is a common and life-threatening condition following severe trauma, characterized by reduced effective circulating blood volume and insufficient tissue perfusion, ultimately leading to an imbalance between oxygen supply and …
Tumors evade macrophage-mediated clearance through mechanistically distinct but functionally convergent anti-phagocytic pathways. This review examines canonical and emerging receptor–ligand “don’t eat me” axes, Siglec-dependent glyco-inhibitory checkpo…
Allergic rhinitis (AR) heterogeneity is usually described by sensitization, symptom burden, or inflammatory profiles, but these descriptors do not establish which mechanism operates in a particular nasal mucosa. This critical narrative review proposes …
Acute pancreatitis (AP) progression involves both the initiating acinar injury and immune responses that sustain or contain subsequent damage. This review integrates evidence on metabolic regulation in macrophages and neutrophils to examine its links t…
Acute pancreatitis (AP) progression involves both the initiating acinar injury and immune responses that sustain or contain subsequent damage. This review integrates evidence on metabolic regulation in macrophages and neutrophils to examine its links t…
The capacity to profoundly change chromatin domains and in turn drive or inhibit gene expression makes chromatin modulators a powerful tool adopted to regulate crucial steps during development and cell lineage specification. These proteins can however …
Renal fibrosis is an important pathogenic characteristic in the course of chronic kidney disease, driven by intricate interactions between mitochondrial failure and epigenetic control. The kidney is highly energy dependent and hence particularly vulner…
By relaxing immune tolerance, immune checkpoint inhibitors can restore antitumor responses but can also cause immune-related adverse events across multiple organs. Efficacy and toxicity occur together in some patients, yet this association does not mea…
Immune checkpoint blockade improves outcomes in defined settings of triple-negative breast cancer (TNBC), but treatment failure does not identify a single biological mechanism or an interchangeable set of remedies. This focused narrative review examine…
Histotripsy is an emerging non-invasive focused-ultrasound technology that mechanically disrupts tissue through controlled bubble activity rather than sustained thermal coagulation. This review distinguishes shock-scattering cavitational histotripsy, i…
