Ying Wang BackgroundT-cell function is regulated by immunometabolism, and lysosomes are signaling hubs. CD68 (LAMP4), traditionally regarded as a monocyte/macrophage marker, has been largely neglected in T cell biology. We aimed to assess the link between CD68 e…
BackgroundInsomnia is increasingly recognized as a systemic disorder involving persistent hyperarousal, neuroendocrine dysregulation, immune activation, and impaired stress adaptation. However, circulating biomarkers reflecting these interconnected bio…
Host–microbial co-metabolites are small bioactive molecules generated through obligatory sequential or complementary enzymatic transformations by both gut microbiota and host tissues, including secondary bile acids, trimethylamine N-oxide (TMAO), indox…
The skin barrier serves as the body’s primary line of defense against exogenous insults and is critical for maintaining systemic homeostasis. Emerging evidence indicates that skin barrier dysfunction is not merely a secondary manifestation of psoriasis…
With the escalating global pollution of nanoplastics, their impacts on organismal health have become a focal concern. The oral-gut microbiota axis plays a pivotal role in host health regulation, yet how nanoplastics influence this axis and drive inflam…
Cellular & Molecular Immunology, Published online: 22 April 2026; doi:10.1038/s41423-026-01413-yEZH2 and intracellular Ca2+ signals interdependently coordinate alloreactive and CAR-T-cell responses
The activation of microglia, which are the resident immune cells of the central nervous system (CNS), underpins the pathogenesis of neuroinflammatory and neurodegenerative diseases. Metabolic reprogramming has recently been recognized as a critical mec…
IntroductionSepsis is a major global health burden associated with high mortality and multiple organ dysfunction, among which liver injury is a key determinant of poor prognosis. However, effective therapeutic strategies for sepsis-associated liver inj…
Cellular & Molecular Immunology, Published online: 08 December 2025; doi:10.1038/s41423-025-01371-xPA28γ-containing tumor-derived exosomes promote T-cell dysfunction in head and neck squamous cell carcinoma
Psoriasis is an inflammatory disease driven by immune dysregulation. Numerous epidemiological studies have confirmed a significant association between psoriasis and mental health disorders, particularly depression. Recent research has increasingly unde…
