Using a modern imaging technology known as cryo-electron microscopy, researchers at UT Southwestern Medical Center have determined the structure of a protein called midnolin that’s crucial to the survival of malignant cells in some leukemias, lymphomas…
A new study led by Keck Medicine of USC researchers may have uncovered an effective combination therapy for glioblastoma, a brain tumor diagnosis with few available effective treatments. According to the National Brain Tumor Society, the average surviv…
In 2017, scientists at Cincinnati Children’s revealed that using antibiotics to protect newborns from dangerous infections often comes with a long-term consequence—a permanently underdeveloped immune system that can make children prone to poor outcomes…
A breakthrough study from Keck Medicine of USC may have found a powerful new triple therapy for glioblastoma, one of the deadliest brain cancers. By combining Tumor Treating Fields (TTFields), which deliver electric waves into tumors, with immunotherap…
A multi-institutional study led by the Icahn School of Medicine at Mount Sinai reports one-third of patients with relapsed or refractory multiple myeloma remained in remission for at least five years following a single infusion of the CAR-T cell therap…
In the quest to design vaccines that better help the body’s immune system fight disease, scientists are always looking for more tools for their arsenal.
A newly developed molecular imaging technique can identify multiple subtypes of triple-negative breast cancer (TNBC), enabling earlier and more accurate detection of this aggressive disease, according a paper published in The Journal of Nuclear Medicin…
Sepsis is when the immune system overshoots its inflammatory reaction to an infection, so strongly that the vital organs begin to shut down. It is life-threatening: each year in the US alone, approximately 750,000 patients are hospitalized for sepsis, …
Pinpointing the precise culprits behind harmful biological processes—such as excessive scarring (fibrosis) in organs like the kidneys and lungs—has long remained challenging even though this affects almost a billion people worldwide. But thanks to the …
Reducing the length of immunotherapy treatment for an advanced skin cancer did not significantly diminish disease control when compared to giving treatments over a longer period, according to research led by the Universities of Sheffield and Leeds and …
Researchers at Tel Aviv University’s Gray Faculty of Medical & Health Sciences conducted a series of experiments using advanced technologies, focusing on the tumor microenvironment in advanced stages of breast cancer. They found that immune system cell…
Modern unhealthy lifestyles and dietary habits have led to a yearly increase in the incidence of metabolism-related liver cancer. A research team from the LKS Faculty of Medicine at the University of Hong Kong (HKUMed), in collaboration with Peking Uni…
Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more
Cellular & Molecular Immunology, Published online: 10 June 2025; doi:10.1038/s41423-025-01307-5Immunopathogenic mechanisms and immunoregulatory therapies in MASLD
Mucosal Immunol. 2025 Jun 7:S1933-0219(25)00058-3. doi: 10.1016/j.mucimm.2025.06.002. Online ahead of print. ABSTRACT Chronic gastrointestinal diseases are a significant global health burden that can require the use of gastrointestinal-cleansing regimens for diagnostics or therapeutic treatment. These regimens are beneficial for facilitating surgical preparation, drug delivery, colorectal cancer screenings, and personal use is common among proponents of … Read more
Multiple sclerosis affects a significant portion of the world’s adult population and is the most common nontraumatic neuroimmunology disorder. Although the specific etiology of multiple sclerosis remains unknown, it has been associated with autoimmune …
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by irreversible lung tissue scarring. Cellular senescence (CS) plays a significant role in IPF pathogenesis, yet the specific molecular mechanisms remain unclear….
BackgroundSpatial metabolomics has revolutionized cancer research by offering unprecedented insights into the metabolic heterogeneity of the tumor microenvironment (TME). Unlike conventional metabolomics, which lacks spatial resolution, spatial metabol…
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease with severe complications. Ferroptosis, an iron-dependent form of apoptosis, encompasses mechanisms including iron overload, lipid peroxidation, redox homeostasis, and reactive oxygen s…
IntroductionInteractions between fibroblast-like synoviocytes (FLSs) and macrophages are pivotal in the pathogenesis of rheumatoid arthritis (RA). Exosomal circular RNAs (circRNAs) are key players in the communication between RA-FLSs and macrophages, y…
IntroductionThe global increase in the elderly population has heightened the need to address nutritional risks in this vulnerable group. However, the relationship between overall dietary antioxidant intake and nutritional risk in the elderly remains un…
BackgroundAlthough allergic rhinitis (AR) and chronic spontaneous urticaria (CSU) share overlapping immunological pathways, their distinct clinical manifestations imply the involvement of unique underlying mechanisms. This study aimed to investigate th…
IntroductionRecent investigations have identified patients of African ancestry (AA) with Multiple Sclerosis (MS), who display more rapid B-cell repopulation after standard semi-annual infusions with an anti-CD20 monoclonal antibody for B cell depletion…
IntroductionMutations in the nucleophosmin 1 gene (NPM1) are common and recurrent molecular abnormalities in acute myeloid leukemia (AML). NPM1 mutations are considered to be positive prognostic factors. The beneficial effect may be due to immune respo…
T cell development and function depend on precise remodeling of the actin cytoskeleton, which regulates migration, cell division, immunological synapse formation, and signal transduction. Regulators of actin include nucleators (Arp2/3, Formins) and bin…
IntroductionThe prognostic management of acute myeloid leukemia (AML) remains a challenge for clinicians. This study aims to construct a novel risk model for AML patient through comprehensive analysis of scRNA and bulk RNA data to optimize the precise …
Cytokines are crucial regulators of inflammation and immune tolerance, making them promising targets for treating immune-related diseases like cancer, infections, and autoimmune disorders. While cytokine-based therapies have shown potential, challenges…
BackgroundCitrate synthase (CS) is a key rate-limiting enzyme in the tricarboxylic acid (TCA) cycle and plays a crucial role in cancer progression. However, the mechanism by which CS promotes liver cancer growth remains unclear. The aim of this study i…
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections in infants, and antibody-dependent enhancement (ADE) presents a significant challenge in vaccine and antibody development. This study investigated the molec…
BackgroundPeople with HIV (PWH) have an increased risk of pulmonary comorbidities compared to people without HIV. The gut microbiome regulates host immunity and is altered in PWH. This study aims to determine potential associations between gut microbio…
Dupilumab is a humanized monoclonal antibody that targets interleukin-4 (IL-4) and IL-13 pathways, commonly used in the treatment of various inflammatory conditions. Despite its therapeutic efficacy, it can also lead to rare adverse reactions, includin…
ObjectiveThis study aimed to analyze gene expression data from psoriasis and control samples, focusing on identifying exosome and cell senescence genes, integrating datasets, and validating batch effect removal using principal component analysis (PCA)….
Anti-GQ1b antibody syndrome is a spectrum of autoimmune neurological disorders that includes Miller Fisher syndrome, Guillain-Barré syndrome (GBS) with ophthalmoplegia, Bickerstaff brainstem encephalitis, and acute ophthalmoplegia without ataxia. These…
IntroductionCDK2 (Cyclin-dependent kinase 2) is an oncogenic cyclin-dependent kinase with potent mitogenic and immunosuppressive functions. Despite extensive research on CDK2 inhibitors, the lack of selectivity has made it unclear whether CDK2 inhibiti…
Lung cancer is a prevalent malignant tumor and the leading cause of cancer-related mortality worldwide. LC is a complex respiratory condition that poses significant challenges for both clinicians and researchers. Crucially, dysregulation of molecular s…
J Immunol. 2025 Jun 9:vkaf115. doi: 10.1093/jimmun/vkaf115. Online ahead of print. ABSTRACT This Pillars of Immunology article revisits the landmark 2007 study by Foster, Hargreaves, and Medzhitov-the first to uncover the mechanistic basis of memory in the innate immune system. This pivotal study marks a fundamental shift in our understanding of innate immunity, revealing an … Read more
J Immunol. 2025 Jun 9:vkaf114. doi: 10.1093/jimmun/vkaf114. Online ahead of print. ABSTRACT Pulmonary type 2 innate lymphocytes (ILC2s) show sex dimorphism in numbers, phenotype, and function. We used a novel strategy of competitive, mixed male-female donor bone marrow chimeras to determine if sex differences in murine ILC2s result from extrinsic factors in the recipient environment … Read more
Curr Opin Immunol. 2025 Jun 7;95:102568. doi: 10.1016/j.coi.2025.102568. Online ahead of print. ABSTRACT Once believed to be limited in its impact on the brain, the immune system is now recognized as a potent modulator of the brain and behavior. This review explores the evolving understanding of the brain-immune axis, highlighting the role of immune cells … Read more
BackgroundImmune checkpoint inhibitors (ICIs) have transformed gastric cancer (GC) treatment, but response heterogeneity necessitates reliable prognostic biomarkers. This meta-analysis investigates the predictive value of metabolic (LDH, glycolytic act…
The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway are crucial elements of the type I interferon (type I IFN) response. cGAS senses both exogenous and endogenous DNA within cells, labeling cGAS-STING as a pivotal anti-tum…
The global immune landscape of SARS-CoV-2 has progressively shifted from a naïve population several years ago to a population that possesses immunity to the virus through infection, vaccination, or a combination of both, known as hybrid immunity. Hybri…
IntroductionL-Tryptophan (Trp) metabolism is impaired across various chronic inflammatory pathologies, including Multiple Sclerosis (MS). Trp processing relies on three metabolic routes, namely Kynurenine, Serotonin and Indole pathways. The host microb…
Messenger RNA (mRNA) vaccines represent a critical avenue for coronavirus disease 2019 (COVID-19) prevention. We developed a COVID-19 mRNA vaccine encoding a codon-optimized full-length ancestral spike (S) protein with a signal peptide, which employs o…
ObjectiveRheumatoid arthritis (RA) is a chronic autoimmune disease marked by inflammation and joint damage. Anthocyanins, such as those from purple sweet potato are known for their anti-inflammatory effects.MethodsThis study evaluated purple sweet pota…
IntroductionThe interaction between the nervous and immune systems is crucial for maintaining homeostasis and can influence disease progression in inflammatory skin diseases, such as atopic dermatitis (AD). Sensory neurons in the skin can secrete neuro…
Pulmonary diseases, such as cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), and ventilator-associated pneumonia (VAP), are attributed to the prolonged infection of the airway and hypersecretion of mucus. Pseudomonas aeruginosa (PA) …
BackgroundAnisakis infections have become a significant public health concern primarily caused by consuming raw or undercooked seafood. This in is due to a shift in global eating habits, and seafood consumption is becoming increasingly popular.Material…
IntroductionSkin microecology significantly affects health, with the microbiome being a complex community of microorganisms. Different niche preferences of microorganisms raise concerns about the adequacy of common sampling methods like swabbing and cy…
BackgroundPediatric solid tumors, particularly neuroblastoma, present significant treatment challenges due to the limited efficacy of existing therapies. Adoptive immunotherapy, which involves transferring immune cells has shown clinical promise. Optim…
BackgroundLung adenocarcinoma (LUAD), the most common histological subtype of lung cancer, demonstrates significant intertumoral heterogeneity. While dendritic cells (DCs) are essential mediators of antitumor immunity, their transcriptional diversity a…
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids, fibrous elements, and cellular debris in the blood vessels. The response-to-retention hypothesis, the leading theory on the pathogenesis of this cardiovascul…
BackgroundTo compare the efficacy and safety of first-line treatments for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC).MethodsWe searched databases, including PubMed, Embase, Cochrane Library, ClinicalTrials.gov, and major international co…
BackgroundPreeclampsia, a hypertensive disorder during pregnancy affecting 2-8% of pregnancies globally, remains a leading cause of maternal and fetal morbidity. Current diagnostic reliance on late-onset clinical features and suboptimal biomarkers unde…
BackgroundGlioma is a common malignant primary brain tumor characterized by a highly immunosuppressive tumor microenvironment and unfavorable prognosis. Transmembrane protein 115 (TMEM115) is a protein-coding gene. It may play a role in the retrograde …
BackgroundMycoplasmopsis bovis, caused by Mycoplasma bovis infection, can lead to severe pneumonia and mastitis in cattle, resulting to significant economic losses to the global cattle industry. The membrane lipoprotein of M. bovis is recognized as a c…
Helicobacter pylori (H. pylori) is a pathogenic bacterium that can survive in the human gastric mucosa and cause chronic infections. More than half of the global population is affected by H. pylori infection, which is closely associated with the develo…
BackgroundThe growing use of immune checkpoint inhibitors (ICIs) in the neoadjuvant treatment of colorectal cancer (CRC) has highlighted immune-related adverse events (irAEs) as a major concern. This study aimed to investigate the characteristics of ir…
IntroductionAdaptations of the immune system throughout gestation have been proposed as important mechanisms regulating successful pregnancy. Dysregulation of the maternal immune system has been associated with adverse maternal and fetal outcomes. The …
IntroductionObesity is a strong risk factor for early-onset colon cancer (EOCC) and is associated with chronic inflammation largely mediated by macrophages. The macrophage-specific metabolite itaconate promotes growth in several types of cancer; howeve…
BackgroundBehcet’s disease (BD) is a lifelong multi-systemic vasculitis disorder that can affect almost any organ. The frequency of involvement of each organ varies depending on demographic and geographical factors. The commonly affected systems includ…
Background
SKV-012 is a novel engineered oncolytic virus (containing the viral neurovirulence ICP34.5 gene transcribed by the Survivin promoter with an upstream genetic component of interleukin-12 (IL-12) driven by the cytomegalovirus promoter) that p…
Background
Tumor resistance is the primary reason for treatment failure in patients with cancer, while oncolytic viruses (OVs), as a novel therapy, have been rapidly advancing through clinical evaluation and are typically assessed in recurrent tumors …
Background
Breast cancer is the most diagnosed malignancy and a leading cause of cancer-related deaths among women globally. Cuproptosis plays a significant role in tumor progression and therapeutic response. Increasing studies suggest that targeting …
Immune checkpoint inhibitors (ICIs) have an expanding role in the management of numerous cancers. Hyperglycaemia is commonly seen in patients treated with ICIs. However, the differential diagnosis for hyperglycaemia is broad, and incorrect diagnosis c…
by Zhao, S., Chen, Y., Bhojnagarwala, P. S., Livingston, C., Jose, J., Gao, Y., Park, D. H., Herlyn, M., Weiner, D. B.
Background
Melanoma is a highly aggressive skin cancer, especially in advanced stages. While current treatments such as targeted therapies and immunotherapies have made significant progress, challenges like drug resistance and limited effectiveness in…
Mucosal Immunol. 2025 Jun 5:S1933-0219(25)00057-1. doi: 10.1016/j.mucimm.2025.06.001. Online ahead of print. ABSTRACT As professional and long-lived immunoglobulin (Ig) producers, B cells represent attractive candidates for adoptive immunotherapy and their highly expressed Ig heavy (IgH) chain locus is ideal for editing. Each of its constant genes, expressed after class switch recombination (CSR), affords an attractive platform … Read more
Curr Opin Immunol. 2025 Jun 4;95:102584. doi: 10.1016/j.coi.2025.102584. Online ahead of print. ABSTRACT Immune tolerance is essential for preventing self-damage while maintaining effective immune responses against foreign insults. Disruptions in this balance contribute to autoimmune and inflammatory conditions, including neuroimmunological disorders that are characterized by aberrant inflammation in the nervous system. Follicular regulatory T (TFR) … Read more
