- Diverse Epithelial Lymphocytes in Zebrafish Revealed Using a Novel Scale Biopsy Methodby inmunoadminJ Immunol. 2024 Nov 6:ji2300818. doi: 10.4049/jimmunol.2300818. Online ahead of print. ABSTRACT Zebrafish (Danio rerio) are a compelling model for studying lymphocytes because zebrafish and humans have similar adaptive immune systems, including their lymphocytes. Antibodies that recognize zebrafish proteins are sparse, so many investigators use transgenic, lymphocyte-specific fluorophore-labeled lines. Human and zebrafish lymphocyte types are … Read more
- Correction: Subclinical Herpes Simplex Virus Type 1 Infections Provide Site-Specific Resistance to an Unrelated Pathogenby inmunoadminJ Immunol. 2024 Nov 6:ji2400607. doi: 10.4049/jimmunol.2400607. Online ahead of print. ABSTRACT Rowe, A. M., H. Yun, B. R. Treat, P. R. Kinchington, and R. L. Hendricks. 2017. Subclinical herpes simplex virus type 1 infections provide site-specific resistance to an unrelated pathogen. J. Immunol. 198: 1706-1717. The second author’s first name was published incorrectly. The … Read more
- Similarities in B Cell Defects between Aging and Obesityby inmunoadminJ Immunol. 2024 Nov 15;213(10):1407-1413. doi: 10.4049/jimmunol.2300670. ABSTRACT The aging population is increasing worldwide, and there is also an increase in the aging population living with overweight and obesity, due to changes in lifestyle and in dietary patterns that elderly individuals experience later in life. Both aging and obesity are conditions of accelerated metabolic dysfunction … Read more
- Top Readsby inmunoadminJ Immunol. 2024 Nov 15;213(10):1403. doi: 10.4049/jimmunol.2490016. NO ABSTRACT PMID:39495901 | DOI:10.4049/jimmunol.2490016
- The HMGBa-HSP70-ATF4-β Axis Restricts White Spot Syndrome Virus Infection in Crayfishby inmunoadminJ Immunol. 2024 Nov 4:ji2400425. doi: 10.4049/jimmunol.2400425. Online ahead of print. ABSTRACT Envelope viruses are the most threatening pathogens to eukaryotes. The search for target genes against envelope viruses is particularly important. The activating transcription factors (ATFs) regulate cancer proliferation, maintain cellular redox homeostasis, extend biological longevity, and respond to viral stimuli. However, the mechanism … Read more
- ISG15 Drives Immune Pathology and Respiratory Failure during Systemic Lymphocytic Choriomeningitis Virus Infectionby inmunoadminJ Immunol. 2024 Nov 4:ji2400042. doi: 10.4049/jimmunol.2400042. Online ahead of print. ABSTRACT ISG15, an IFN-stimulated gene, plays a crucial role in modulating immune responses during viral infections. Its upregulation is part of the host’s defense mechanism against viruses, contributing to the antiviral state of cells. However, altered ISG15 expression can also lead to immune dysregulation … Read more
- The MicroRNA miR-223 Constrains Colitis-associated Tumorigenesis by Limiting Myeloid Cell Infiltration and Chemokine Expressionby inmunoadminJ Immunol. 2024 Nov 1:ji2400129. doi: 10.4049/jimmunol.2400129. Online ahead of print. ABSTRACT Aberrant intestinal inflammation plays a critical role in the development of colitis-associated colorectal cancer (CAC), yet the mechanisms controlling tumor development by the myeloid immune compartment are not fully understood. Although altered microRNA expression is observed in CAC, it is also unclear how … Read more
- Nrf2 Regulates Inflammation by Modulating Dendritic Cell-T Cell Crosstalk during Viral-Bacterial Superinfectionby inmunoadminJ Immunol. 2024 Nov 1:ji2400322. doi: 10.4049/jimmunol.2400322. Online ahead of print. ABSTRACT Every year millions of people are infected with influenza, which can be complicated by secondary bacterial pneumonia. One factor that may contribute to increased susceptibility to secondary bacterial infection is the modulation of inflammatory cytokines. NF erythroid 2-related factor 2 (Nrf2) has been … Read more
- Neonatal Neutrophil-mediated Control of Bordetella pertussis Is Disrupted by Pertussis Toxinby inmunoadminJ Immunol. 2024 Oct 30:ji2400363. doi: 10.4049/jimmunol.2400363. Online ahead of print. ABSTRACT The increased susceptibility of infants and young children to some diseases has often been explained as the neonatal immune system (NIS) being incomplete and/or underdeveloped. However, our recent work demonstrated that neonatal mice could clear a Bordetella pertussis (Bp) strain lacking pertussis toxin … Read more
- Regulation and Dynamics of IFN-β Expression Revealed with a Knockin Reporter Mouseby inmunoadminJ Immunol. 2024 Oct 30:ji2400227. doi: 10.4049/jimmunol.2400227. Online ahead of print. ABSTRACT IFN-β is a potent antiviral cytokine and the first member of the type I IFN family of cytokines to be induced during the antiviral response. IFN-β plays an essential protective role in host defense against virus infections, as well as a pathogenic role … Read more
- Local Controlled Delivery of IL-4 Decreases Inflammatory Bone Loss in a Murine Model of Periodontal Diseaseby inmunoadminJ Immunol. 2024 Oct 28:ji2400332. doi: 10.4049/jimmunol.2400332. Online ahead of print. ABSTRACT Chronic inflammatory diseases are a leading global health problem. In many of these diseases, the consistent presence of systemic low-grade inflammation induces tissue damage. This is true in conditions such as diabetes, arthritis, and autoimmune disorders, where an overactive and uncontrolled host immune … Read more
- Identification of a Specific Granular Marker of Zebrafish Eosinophils Enables Development of New Tools for Their Studyby inmunoadminJ Immunol. 2024 Oct 28:ji2400259. doi: 10.4049/jimmunol.2400259. Online ahead of print. ABSTRACT Eosinophils control many aspects of the vertebrate innate immune response. They contribute to homeostasis, inflammatory conditions and defense against pathogens. With the varied functions of eosinophils, they have been found to play both protective and pathogenic roles in many diseases. The zebrafish (Danio … Read more
- IL-33 Increases the Magnitude of the Tissue-Resident Memory T Cell Response in Intestinal Tissues during Local Infectionby inmunoadminJ Immunol. 2024 Oct 28:ji2400323. doi: 10.4049/jimmunol.2400323. Online ahead of print. ABSTRACT IL-33 plays an important role in the early programming of CD8 T cells; however, its contribution to the differentiation of tissue-resident memory T cells in vivo remains poorly defined. After infection of mice with Yersinia pseudotuberculosis, IL-33 expression was increased in the intestinal … Read more
- Rhesus Macaque Killer Cell Ig-like Receptor Domain 0 Glycans Impact Surface Expression and Ligand Specificityby inmunoadminJ Immunol. 2024 Oct 28:ji2400466. doi: 10.4049/jimmunol.2400466. Online ahead of print. ABSTRACT Defining the MHC class I ligands of rhesus macaque killer cell Ig-like receptors (KIRs) is fundamental to NK cell biology in this species as a model for infectious diseases and comparative immunogenetics. Several rhesus macaque KIRs belong to a phylogenetically distinct group with … Read more
- The Marginal Zone B Cell Compartment and T Cell-independent Antibody Responses Are Supported by B Cell Intrinsic Expression of IRF1by inmunoadminJ Immunol. 2024 Oct 25:ji2300575. doi: 10.4049/jimmunol.2300575. Online ahead of print. ABSTRACT The prototypic IFN-inducible transcription factor, IRF1, not only controls inflammatory gene expression but also regulates T cell and macrophage fate specification and function. Using bone marrow chimeras (80% B6.129S2-Ighmtm1Cgn/J [µMT] + 20% B6.129S2-Irf1tm1Mak/J [Irf1-/-]), we show that IRF1 expression in B cells is … Read more
- Single-cell Sequencing of Circulating Human Plasmablasts during Staphylococcus aureus Bacteremiaby inmunoadminJ Immunol. 2024 Oct 25:ji2300858. doi: 10.4049/jimmunol.2300858. Online ahead of print. ABSTRACT Staphylococcus aureus is the major cause of healthcare-associated infections, including life-threatening conditions as bacteremia, endocarditis, and implant-associated infections. Despite adequate antibiotic treatment, the mortality of S. aureus bacteremia remains high. This calls for different strategies to treat this infection. In past years, sequencing … Read more
- Development of a Spectral Flow Cytometry Analysis Pipeline for High-dimensional Immune Cell Characterizationby inmunoadminJ Immunol. 2024 Oct 25:ji2400370. doi: 10.4049/jimmunol.2400370. Online ahead of print. ABSTRACT Flow cytometry is used for immune cell analysis for cell composition and function. Spectral flow cytometry allows for high-dimensional analysis of immune cells, overcoming limitations of conventional flow cytometry. However, analyzing data from large Ab panels is challenging using traditional biaxial gating strategies. … Read more
- TP53 Codon 72 Polymorphism Impacts Macrophage Activation through Reactive Oxygen Species-Dependent Cell Signaling Alterationsby inmunoadminJ Immunol. 2024 Oct 25:ji2400212. doi: 10.4049/jimmunol.2400212. Online ahead of print. ABSTRACT The role of the most common TP53 single-nucleotide polymorphism (SNP) at codon 72, which encodes for proline (P72) or arginine (R72), in the regulation of the immune system has not yet been thoroughly explored. We found that this SNP contributes to aggravated inflammatory … Read more
- Suppression of Class Switch Recombination to IgA by RASA2 and RASA3 through Inhibition of TGF-β Signalingby inmunoadminJ Immunol. 2024 Oct 25:ji2400353. doi: 10.4049/jimmunol.2400353. Online ahead of print. ABSTRACT Abs play a pivotal role in adaptive immunity by binding to pathogens and initiating immune responses against infections. Processes such as somatic hypermutation and class switch recombination (CSR) enhance Ab affinity and effector functions. We previously carried out a CRISPR/Cas9 screen in the … Read more
- Multiplexed Antibody Sequencing and Profiling of the Human Hemagglutinin-specific Memory B Cell Response following Influenza Vaccinationby inmunoadminJ Immunol. 2024 Oct 23:ji2400326. doi: 10.4049/jimmunol.2400326. Online ahead of print. ABSTRACT Influenza virus is a highly contagious respiratory pathogen causing between 9.4 and 41 million infections per year in the United States in the last decade. Annual vaccination is recommended by the World Health Organization, with the goal to reduce influenza severity and transmission. … Read more
- CXCL12/CXCR4 Axis Promotes the Chemotaxis and Phagocytosis of B Cells through the PI3K-AKT Signaling Pathway in an Early Vertebrateby inmunoadminJ Immunol. 2024 Oct 23:ji2300562. doi: 10.4049/jimmunol.2300562. Online ahead of print. ABSTRACT Chemokines play crucial roles in the regulation of immune cell migration and development. The CXCL12/CXCR4 axis has been extensively studied in mammals, but its regulatory mechanism in teleost fish remains unclear. In this study, we used Nile tilapia (Oreochromis niloticus) as a teleost … Read more
- Skin-resident T Cells Contribute to the Dynamic Disease Manifestations of Psoriasisby inmunoadminJ Immunol. 2024 Nov 1;213(9):1267-1277. doi: 10.4049/jimmunol.2400020. ABSTRACT The human skin forms a dynamic barrier to physical injuries and microbial invasion. Constant interactions between stroma and tissue-confined immune cells maintain skin homeostasis. However, the cellular interactions that maintain skin health also contribute to focal immunopathology. Psoriasis is a common disease that manifests with focal pathology … Read more
- Top Readsby inmunoadminJ Immunol. 2024 Nov 1;213(9):1265. doi: 10.4049/jimmunol.2490015. NO ABSTRACT PMID:39432868 | DOI:10.4049/jimmunol.2490015
- Homeostatic Macrophages Prevent Preterm Birth and Improve Neonatal Outcomes by Mitigating In Utero Sterile Inflammation in Miceby inmunoadminJ Immunol. 2024 Oct 21:ji2400467. doi: 10.4049/jimmunol.2400467. Online ahead of print. ABSTRACT Preterm birth (PTB), often preceded by preterm labor, is a major cause of neonatal morbidity and mortality worldwide. Most PTB cases involve intra-amniotic inflammation without detectable microorganisms, termed in utero sterile inflammation, for which there is no established treatment. In this study, we … Read more
- The Inhibitory Effects of a Factor B-Binding DNA Aptamer Family Supersede the Gain of Function of Factor B Variants Associated with Atypical Hemolytic Uremic Syndromeby inmunoadminJ Immunol. 2024 Oct 21:ji2400420. doi: 10.4049/jimmunol.2400420. Online ahead of print. ABSTRACT Aptamers are short, single-stranded oligonucleotides that selectively bind to target biomolecules. Although they generally exhibit good binding specificity, their affinities are often limited because of the relative lack of hydrophobic groups in nucleic acids. Chemically modified nucleotides incorporating hydrophobic structures into uracil have … Read more
- Virus-specific Th17 Cells Are Induced by Human Cytomegalovirus after Renal Transplantationby inmunoadminJ Immunol. 2024 Oct 18:ji2300742. doi: 10.4049/jimmunol.2300742. Online ahead of print. ABSTRACT CMV infection and Th17 cells are independently associated with increased risk for late allograft loss after renal transplantation. Although CMV-specific Th17 cells are detectable in animal models and nontransplant clinical populations, evidence linking CMV and Th17 cells after renal transplantation remains unclear. This … Read more
- Enhancement of Autophagy in Macrophages via the p120-Catenin-Mediated mTOR Signaling Pathwayby inmunoadminJ Immunol. 2024 Oct 18:ji2400189. doi: 10.4049/jimmunol.2400189. Online ahead of print. ABSTRACT Autophagy serves as a critical regulator of immune responses in sepsis. Macrophages are vital constituents of both innate and adaptive immunity. In this study, we delved into the intricate role of p120-catenin (p120) in orchestrating autophagy in macrophages in response to endotoxin stimulation. … Read more
- Myeloid Cell-Specific Deletion of AMPKα1 Worsens Ocular Bacterial Infection by Skewing Macrophage Phenotypesby inmunoadminJ Immunol. 2024 Oct 16:ji2400282. doi: 10.4049/jimmunol.2400282. Online ahead of print. ABSTRACT AMP-activated protein kinase (AMPK) plays a crucial role in governing essential cellular functions such as growth, proliferation, and survival. Previously, we observed increased vulnerability to bacterial (Staphylococcus aureus) endophthalmitis in global AMPKα1 knockout mice. In this study, we investigated the specific involvement of … Read more
- Alarm Functions of PD-1+ Brain-Resident Memory T Cellsby inmunoadminJ Immunol. 2024 Oct 16:ji2400295. doi: 10.4049/jimmunol.2400295. Online ahead of print. ABSTRACT Resident memory T cells (TRM cells) have been described in barrier tissues as having a “sensing and alarm” function where, upon sensing cognate Ag, they alarm the surrounding tissue and orchestrate local recruitment and activation of immune cells. In the immunologically unique and … Read more
- Hepatitis B Virus Increases SphK1-S1P Synthesis by Promoting the Availability of the Transcription Factor USF1by inmunoadminJ Immunol. 2024 Oct 14:ji2400088. doi: 10.4049/jimmunol.2400088. Online ahead of print. ABSTRACT Hepatitis B virus (HBV) is the most common chronic viral infection globally, affecting ∼360 million people and causing about 1 million deaths annually due to end-stage liver disease or hepatocellular carcinoma. Current antiviral treatments rarely achieve a functional cure for chronic hepatitis B, … Read more
- IDO2 Drives Autoantibody Production and Joint Inflammation in a Preclinical Model of Arthritis by Repressing Runx1 Function in B Cellsby inmunoadminJ Immunol. 2024 Oct 14:ji2400445. doi: 10.4049/jimmunol.2400445. Online ahead of print. ABSTRACT The immunomodulatory enzyme IDO2 is an essential mediator of autoantibody production and joint inflammation in preclinical models of autoimmune arthritis. Although originally identified as a tryptophan-catabolizing enzyme, we recently discovered a previously unknown nonenzymatic pathway is essential for the proarthritic function of IDO2. … Read more
- Fth1-mScarlet Reports Monocyte State during Lipopolysaccharide-induced Lung Inflammationby inmunoadminJ Immunol. 2024 Oct 11:ji2400215. doi: 10.4049/jimmunol.2400215. Online ahead of print. ABSTRACT Monocytes and macrophages are central to host defense but also contribute to inflammation-associated pathology. Efforts to manipulate monocyte and macrophage function are limited by our ability to effectively quantify the functional programs of these cells. We identified the gene Fth1, which encodes the … Read more
- NK Cell and Monocyte Dysfunction in Multisystem Inflammatory Syndrome in Childrenby inmunoadminJ Immunol. 2024 Oct 11:ji2400395. doi: 10.4049/jimmunol.2400395. Online ahead of print. ABSTRACT Multisystem inflammatory syndrome in children (MIS-C) is a severe complication of SARS-CoV-2 infection characterized by multiorgan involvement and inflammation. Testing of cellular function ex vivo to understand the aberrant immune response in MIS-C is limited. Despite strong Ab production in MIS-C, SARS-CoV-2 nucleic … Read more
- Correction: CCR1 and CCR2 Coexpression on Monocytes Is Nonredundant and Delineates a Distinct Monocyte Subpopulationby inmunoadminJ Immunol. 2024 Oct 9:ji2400470. doi: 10.4049/jimmunol.2400470. Online ahead of print. ABSTRACT Medina-Ruiz, L., R. Bartolini, H. Mathie, H. A. Halawa, F. Schuette, M. Cunningham, and G. J. Graham. 2024. CCR1 and CCR2 coexpression on monocytes is nonredundant and delineates a distinct monocyte subpopulation. J. Immunol. 213: 214-225. Fabian Schuette was inadvertently left off the … Read more
- Repeated CXCR4 Blockade by Plerixafor Attenuates Transplant Vasculopathy in Murine Aortic Allograftsby inmunoadminJ Immunol. 2024 Oct 9:ji2300632. doi: 10.4049/jimmunol.2300632. Online ahead of print. ABSTRACT Plerixafor, a hematopoietic stem cell mobilization agent, increases the peripheral blood content of effector and regulatory T cells and may have beneficial effects on cardiac allograft vasculopathy. The aim of the current study was to evaluate its effects in a murine aortic allograft … Read more
- Top Readsby inmunoadminJ Immunol. 2024 Jul 15;213(2):107. doi: 10.4049/jimmunol.2490007. NO ABSTRACT PMID:39382447 | DOI:10.4049/jimmunol.2490007
- IL-17: A Critical Cytokine for Defense against Oral Candidiasisby inmunoadminJ Immunol. 2024 Oct 15;213(8):1049-1051. doi: 10.4049/jimmunol.2400510. ABSTRACT This Pillars of Immunology article is a commentary on “Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis,” a pivotal article written by H. R. Conti, F. Shen, N. Nayyar, E. Stocum, J. N. Sun, M. J. Lindemann, A. W. Ho, … Read more
- Top Readsby inmunoadminJ Immunol. 2024 Oct 15;213(8):1047. doi: 10.4049/jimmunol.2490014. NO ABSTRACT PMID:39374467 | DOI:10.4049/jimmunol.2490014
- The Type 1 Diabetes-Associated Single Nucleotide Polymorphism rs1990760 in IFIH1 Is Associated with Increased Basal Type I IFNs and IFN-stimulated Gene Expressionby inmunoadminJ Immunol. 2024 Oct 7:ji2400344. doi: 10.4049/jimmunol.2400344. Online ahead of print. ABSTRACT Type 1 diabetes (T1D) is a chronic autoimmune disease that is caused by a combination of genetic and environmental risk factors. In this study, we sought to determine whether a known genetic risk factor, the rs1990760 single nucleotide polymorphism (SNP) (A946T) in IFIH1, … Read more
- In Vivo CRISPR Screening Reveals CHD7 as a Positive Regulator of Short-lived Effector Cellsby inmunoadminJ Immunol. 2024 Oct 7:ji2400213. doi: 10.4049/jimmunol.2400213. Online ahead of print. ABSTRACT CD8+ T cells differentiate into two subpopulations in response to acute viral infection: memory precursor effector cells (MPECs) and short-lived effector cells (SLECs). MPECs and SLECs are epigenetically distinct; however, the epigenetic regulators required for formation of these subpopulations are mostly unknown. In … Read more
- High-dimensional Immune Profiles and Machine Learning May Predict Acute Myeloid Leukemia Relapse Early following Transplantby inmunoadminJ Immunol. 2024 Oct 7:ji2300827. doi: 10.4049/jimmunol.2300827. Online ahead of print. ABSTRACT Identification of early immune signatures associated with acute myeloid leukemia (AML) relapse following hematopoietic stem cell transplant (HSCT) is critical for patient outcomes. We analyzed PBMCs from 58 patients with AML undergoing HSCT, focusing on T cell subsets and functional profiles. High-dimensional flow … Read more
- Immunometabolic Mechanisms of LANCL2 in CD4+ T Cells and Phagocytes Provide Protection from Systemic Lupus Erythematosusby inmunoadminJ Immunol. 2024 Oct 4:ji2400127. doi: 10.4049/jimmunol.2400127. Online ahead of print. ABSTRACT Lanthionine synthetase C-like 2 (LANCL2) is an immunoregulatory therapeutic target for autoimmune diseases. NIM-1324 is an investigational new drug aimed at addressing the unmet clinical needs of patients with systemic lupus erythematosus (SLE) by targeting the LANCL2 immunometabolic pathway. In R848 and bm12 … Read more
- Microbe-binding Antibodies in the Female Genital Tract: Associations with the Vaginal Microbiome and Genital Immunologyby inmunoadminJ Immunol. 2024 Sep 30:ji2400233. doi: 10.4049/jimmunol.2400233. Online ahead of print. ABSTRACT Bacteria-Ig interactions maintain homeostasis in the gut through the clearance of pathogenic bacteria and the development of immune tolerance to inflammatory bacteria; whether similar interactions modulate inflammation and bacterial colonization in the female genital tract is uncertain. In this study, we used a … Read more
- Tim-3 Is Required for Regulatory T Cell-Mediated Promotion of T Cell Exhaustion and Viral Persistence during Chronic Lymphocytic Choriomeningitis Virus Infectionby inmunoadminJ Immunol. 2024 Sep 30:ji2400119. doi: 10.4049/jimmunol.2400119. Online ahead of print. ABSTRACT Expression of T cell Ig and mucin domain-containing protein 3 (Tim-3) is upregulated on regulatory T cells (Tregs) during chronic viral infections. In several murine and human chronic infections, the expression of Tim-3 is associated with poor control of viral burden and impaired … Read more
- Intravenous Bacillus Calmette-Guérin (BCG) Induces a More Potent Airway and Lung Immune Response than Intradermal BCG in Simian Immunodeficiency Virus-infected Macaquesby inmunoadminJ Immunol. 2024 Sep 23:ji2400417. doi: 10.4049/jimmunol.2400417. Online ahead of print. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis, is one of the leading causes of death due to an infectious agent. Coinfection with HIV exacerbates M. tuberculosis infection outcomes in people living with HIV. Bacillus Calmette-Guérin (BCG), the only approved TB vaccine, is effective in … Read more
- MARCH8 Mediates K27-Linked Polyubiquitination of IL-7 Receptor α to Negatively Regulate IL-7-Triggered T Cell Homeostasisby inmunoadminJ Immunol. 2024 Sep 23:ji2400253. doi: 10.4049/jimmunol.2400253. Online ahead of print. ABSTRACT IL-7 is a cytokine produced by stromal cells, which binds to IL-7Rα and plays an important role for homeostasis of T lymphocytes. Excessive activities of IL-7-triggered signaling pathways causes autoimmune diseases. How IL-7-triggered signaling and immune effects are regulated is not fully understood. … Read more
- Type I IFN Induces TCR-dependent and -independent Antimicrobial Responses in γδ Intraepithelial Lymphocytesby inmunoadminJ Immunol. 2024 Sep 23:ji2400138. doi: 10.4049/jimmunol.2400138. Online ahead of print. ABSTRACT Intraepithelial lymphocytes (IELs) expressing the TCRγδ survey the intestinal epithelium to limit the invasion of microbial pathogens. The production of type I IFN is a central component of an antiviral immune response, yet how these proinflammatory cytokines contribute to γδ IEL effector function … Read more
- Circulating Immune Cells from Early- and Late-onset Pre-eclampsia Displays Distinct Profiles with Differential Impact on Endothelial Activationby inmunoadminJ Immunol. 2024 Sep 20:ji2400196. doi: 10.4049/jimmunol.2400196. Online ahead of print. ABSTRACT Pre-eclampsia (PE) affects 5-8% of pregnancies and has detrimental effects on maternal-fetal health. PE is characterized by de novo hypertension after 20 wk of gestation and end-organ damage. Systemic inflammatory imbalance has been associated with PE, but its contribution to the pathology is … Read more
- IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translationby inmunoadminJ Immunol. 2024 Sep 20:ji2400331. doi: 10.4049/jimmunol.2400331. Online ahead of print. ABSTRACT Expression of IL-15 on the surface of human graft endothelial cells (ECs) bound to the IL-15Rα subunit can increase the activation of CTLs, potentiating allograft rejection. Our previous work showed that surface expression of this protein complex could be induced by alloantibody-mediated complement … Read more
- Rapamycin Prevents Expansion of Costimulation Blockade-resistant CD8+ Alloreactive Memory Cells following Depletional Induction in Renal Transplant Recipientsby inmunoadminJ Immunol. 2024 Sep 20:ji2400146. doi: 10.4049/jimmunol.2400146. Online ahead of print. ABSTRACT Alemtuzumab induction with belatacept/rapamycin-based maintenance immunotherapy (ABR) prevents kidney allograft rejection and specifically limits early costimulation blockade-resistant rejection (CoBRR). To evaluate the mechanisms by which this regimen alters CoBRR, we characterized the phenotype and functional response of preexisting memory cells to allogeneic endothelial … Read more
- Chitinase 3-like-1 Inhibits Innate Antitumor and Tissue Remodeling Immune Responses by Regulating CD47-SIRPα- and CD24-Siglec10-Mediated Phagocytosisby inmunoadminJ Immunol. 2024 Sep 18:ji2400035. doi: 10.4049/jimmunol.2400035. Online ahead of print. ABSTRACT Innate immune responses such as phagocytosis are critically linked to the generation of adaptive immune responses against the neoantigens in cancer and the efferocytosis that is essential for homeostasis in diseases characterized by lung injury, inflammation, and remodeling as in chronic obstructive pulmonary … Read more
- Integrins α5β1 and αvβ3 Differentially Participate in the Recruitment and Reprogramming of Tumor-associated Macrophages in the In Vitro and In Vivo Models of Breast Tumorby inmunoadminJ Immunol. 2024 Sep 27:ji2400180. doi: 10.4049/jimmunol.2400180. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) drive the protumorigenic responses and facilitate tumor progression via matrix remodeling, angiogenesis, and immunosuppression by interacting with extracellular matrix proteins via integrins. However, the expression dynamics of integrin and its correlation with TAM functional programming in the tumors remain unexplored. … Read more
- Developmental Vitamin D Deficiency and the Vitamin D Receptor Control Hematopoiesisby inmunoadminJ Immunol. 2024 Sep 25:ji2400292. doi: 10.4049/jimmunol.2400292. Online ahead of print. ABSTRACT Vitamin D status, the vitamin D receptor (VDR), and the ability to produce active vitamin D [1,25(OH)2D, regulated by Cyp27b1] regulate fetal and adult hematopoiesis. Transgenic reporter mice that express the tdTomato RFP as an indication of Vdr expression were used to identify … Read more
- The G Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell Migrationby inmunoadminJ Immunol. 2024 Sep 25:ji2400228. doi: 10.4049/jimmunol.2400228. Online ahead of print. ABSTRACT G protein-coupled receptors (GPCRs) represent the largest family of surface receptors and are responsible for key physiological functions, including cell growth, neurotransmission, hormone release, and cell migration. The GPCR 56 (GPR56), encoded by ADGRG1, is an adhesion GPCR found on diverse cell types, … Read more