Nature Reviews Immunology, Published online: 14 January 2025; doi:10.1038/s41577-025-01133-wA study in Cell shows that gasdermin D pores can be transferred from cell to cell via extracellular vesicles and induce pyroptotic cell death i…
Nature Reviews Immunology, Published online: 14 January 2025; doi:10.1038/s41577-025-01134-9A phenomenon called ‘autosomal random monoallelic expression’ (aRMAE) may explain phenotypic variability of clinical disease in carriers of mut…
Nature Reviews Immunology, Published online: 08 January 2025; doi:10.1038/s41577-024-01128-zA preprint by Xu et al. shows that MHC-pseudotyped retroviruses can reprogramme, activate and expand tumour-specific T cell populations in vivo.
Nature Reviews Immunology, Published online: 07 January 2025; doi:10.1038/s41577-024-01124-3This Perspective discusses current knowledge of the diverse roles played by different macrophage populations within the Mycobacterium tuberculo…
Nature Reviews Immunology, Published online: 07 January 2025; doi:10.1038/s41577-024-01112-7This Review summarizes mechanisms for the regulation of cGAS–STING signalling, describes its crosstalk with other signalling pathways, and outl…
Nature Reviews Immunology, Published online: 06 January 2025; doi:10.1038/s41577-024-01119-0This Review discusses recent advances in our understanding of the biology of endogenous tissue regeneration in the thymus, highlighting the cli…
Nature Reviews Immunology, Published online: 02 January 2025; doi:10.1038/s41577-024-01111-8Here the authors describe the different ways that cancer cells evade the immune system and how these mechanisms impact immunoediting and tumour…
Nature Reviews Immunology, Published online: 02 January 2025; doi:10.1038/s41577-024-01127-0Stress-induced gut leakage and immune activation lead to the release of IL-22, which acts directly on septal neurons in the brain to dampen the…
Nature Reviews Immunology, Published online: 19 December 2024; doi:10.1038/s41577-024-01126-1A transposon-derived isoform of the type I interferon (IFN) receptor IFNAR2 can serve as a decoy receptor to regulate IFN signalling.
Nature Reviews Immunology, Published online: 16 December 2024; doi:10.1038/s41577-024-01125-2Yan et al. report the identification of a population of muscle spindle macrophages, which regulate the muscle stretch reflex through glutamate…
Nature Reviews Immunology, Published online: 09 December 2024; doi:10.1038/s41577-024-01104-7This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore th…
Nature Reviews Immunology, Published online: 09 December 2024; doi:10.1038/s41577-024-01118-1A preprint by Chung et al. presents a framework for the use of transcriptomic and epigenomic data to identify novel transcription factors driv…
Nature Reviews Immunology, Published online: 05 December 2024; doi:10.1038/s41577-024-01123-4Author Correction: Inflammasome components as new therapeutic targets in inflammatory disease
Nature Reviews Immunology, Published online: 05 December 2024; doi:10.1038/s41577-024-01122-5Publisher Correction: Inflammasome components as new therapeutic targets in inflammatory disease
Nature Reviews Immunology, Published online: 03 December 2024; doi:10.1038/s41577-024-01121-6Endogenous self-peptides derived from CNS antigens are presented on MHC class II molecules at the borders of the CNS and expand suppressive po…
Nature Reviews Immunology, Published online: 29 November 2024; doi:10.1038/s41577-024-01120-7Sialylated IgG protects against severe influenza by inducing the transcriptional repressor REST, which dampens the inflammatory response and p…
Nature Reviews Immunology, Published online: 12 November 2024; doi:10.1038/s41577-024-01100-xThe oral mucosa is a critical barrier tissue that is continually exposed to pathogens, but antiviral immune responses in this tissue are poorl…
Nature Reviews Immunology, Published online: 11 November 2024; doi:10.1038/s41577-024-01105-6The basic-residue-rich sequence (BRS) is a common motif located in the cytoplasmic tail of most immunoreceptors. This Perspective highlights t…
Nature Reviews Immunology, Published online: 07 November 2024; doi:10.1038/s41577-024-01103-8This Review discusses how adipose tissue can regulate host immune function via the release of adipokines, including adiponectin, leptin and va…
Nature Reviews Immunology, Published online: 07 November 2024; doi:10.1038/s41577-024-01102-9Thirty years ago, Polly Matzinger introduced the ‘danger theory of immunity’, which proposed that danger and damage have a decisive role in im…
Nature Reviews Immunology, Published online: 31 October 2024; doi:10.1038/s41577-024-01099-1Single-cell multi-omic profiling has revealed how the immune system is established in the human embryo, mapping in unprecedented detail the eme…
Nature Reviews Immunology, Published online: 30 October 2024; doi:10.1038/s41577-024-01109-2Inflammation and fibrosis are linked to organ dysfunction. Two studies in Nature investigate the cross-talk between immune cells and fibroblast…
Nature Reviews Immunology, Published online: 28 October 2024; doi:10.1038/s41577-024-01107-4Blocking the RNase activity of IRE1α can convert ‘cold’ tumours to immunologically ‘hot’ ones that respond to chemo-immunotherapy.
Nature Reviews Immunology, Published online: 28 October 2024; doi:10.1038/s41577-024-01110-9Increased intratumoral acidity associated with a high-fat diet accelarates tumour growth through the acid-sensing receptor GPR65 on tumour-asso…
Nature Reviews Immunology, Published online: 22 October 2024; doi:10.1038/s41577-024-01106-5Two studies in Cell Stem Cell and Nature use single-cell transcriptomics of human fetal tissue to investigate the roles of tissue-resident macr…
Nature Reviews Immunology, Published online: 21 October 2024; doi:10.1038/s41577-024-01093-7CAR T cells have transformed the treatment of some haematological cancers. This Perspective explores how insights into T cell receptor signalli…
Nature Reviews Immunology, Published online: 21 October 2024; doi:10.1038/s41577-024-01091-9This Perspective considers present and historical paradigms of therapeutic cancer vaccines and describes a conceptual framework, termed Vax-Inn…
Nature Reviews Immunology, Published online: 17 October 2024; doi:10.1038/s41577-024-01098-2This Review provides an overview of arginine and arginase function in immune cells, at the steady state and during disease. It considers the re…
Nature Reviews Immunology, Published online: 16 October 2024; doi:10.1038/s41577-024-01088-4The aryl hydrocarbon receptor (AHR) can sense and initiate immune responses to many different infectious organisms. Here, Moura-Alves and colle…
Nature Reviews Immunology, Published online: 11 October 2024; doi:10.1038/s41577-024-01101-wFebrile temperatures disrupt metabolism and induce DNA damage disproportionately in T helper 1 cell subsets. Cells that survive apoptosis and a…
Nature Reviews Immunology, Published online: 04 October 2024; doi:10.1038/s41577-024-01097-3CD8+ T cells are functionally impaired during chronic HBV infection. Recent findings from preclinical models and studies of chronically infecte…
Nature Reviews Immunology, Published online: 30 September 2024; doi:10.1038/s41577-024-01087-5Oxygen levels vary throughout the body and immune cells must adapt to these changes, both during homeostasis and in disease. Here, the author…
Nature Reviews Immunology, Published online: 27 September 2024; doi:10.1038/s41577-024-01081-xMacrophages are associated with many human diseases but are challenging to study in vivo. Here, Ginhoux and colleagues discuss how iMacs — ma…
Nature Reviews Immunology, Published online: 24 September 2024; doi:10.1038/s41577-024-01083-9Technological advances in cellular and molecular immunology are providing unprecedented new insights into evolutionary immunology. This Persp…
Nature Reviews Immunology, Published online: 24 September 2024; doi:10.1038/s41577-024-01094-6Publisher Correction: Role of thymic stromal lymphopoietin in allergy and beyond
Nature Reviews Immunology, Published online: 24 September 2024; doi:10.1038/s41577-024-01096-4MICL regulates neutrophil responses by serving as an inhibitory pattern-recognition receptor for NETs.
Nature Reviews Immunology, Published online: 20 September 2024; doi:10.1038/s41577-024-01095-5A study in Cell describes a platform to supply exogenous mitochondria to CD8+ T cells via nanotubes, which boosts their antitumour efficacy.
Nature Reviews Immunology, Published online: 18 September 2024; doi:10.1038/s41577-024-01080-yMacrophages are innate immune sentinels providing frontline defence against infection. This Review describes the inducible mechanisms used by…
Nature Reviews Immunology, Published online: 18 September 2024; doi:10.1038/s41577-024-01076-8For effective central T cell tolerance, developing thymocytes must encounter a diverse range of self-antigens presented by various thymic cel…
Nature Reviews Immunology, Published online: 17 September 2024; doi:10.1038/s41577-024-01079-5Dendritic cells (DCs) act as gatekeepers between immunity and tolerance. Initially, it was postulated that mature DCs promote effector T cell…
Nature Reviews Immunology, Published online: 16 September 2024; doi:10.1038/s41577-024-01090-wFrancesca Di Rosa works on T cells and is committed to science outreach. Together with Adrian Hayday, she recently conceptualized and deliver…
Nature Reviews Immunology, Published online: 16 September 2024; doi:10.1038/s41577-024-01089-3Starkl et al. show that mast cells have a key role in the metabolic network that underlies postoperative pain and demonstrate that this can b…
Nature Reviews Immunology, Published online: 10 September 2024; doi:10.1038/s41577-024-01073-xThe mechanisms by which antigen triggers B-cell activation are incompletely understood. In this Review, Degn and Tolar discuss the different …
Nature Reviews Immunology, Published online: 09 September 2024; doi:10.1038/s41577-024-01075-9Inflammasomes are signalling machines that drive inflammation. This Review highlights the signalling biology of inflammasomes and how we can …
Nature Reviews Immunology, Published online: 09 September 2024; doi:10.1038/s41577-024-01085-7Anne Spurkland is a professor of medicine, and her research interests include T cell activation and autoimmunity. She is also an avid baker o…
Nature Reviews Immunology, Published online: 06 September 2024; doi:10.1038/s41577-024-01077-7Oral tolerance describes how the oral administration of harmless antigens (such as dietary proteins) leads to systemic immune unresponsivenes…
Nature Reviews Immunology, Published online: 04 September 2024; doi:10.1038/s41577-024-01070-0Sex-specific differences in immunity are determined by genetics and by hormones. This Comment discusses first insights into the consequences …
Nature Reviews Immunology, Published online: 30 August 2024; doi:10.1038/s41577-024-01084-8In this Tools of the Trade article, Mayar Allam and Ahmet Coskun describe how they combined spatial metabolomics and proteomics profiling — in a…
Nature Reviews Immunology, Published online: 30 August 2024; doi:10.1038/s41577-024-01064-yThis Review provides an overview of the immune system of the eye at steady state and in ocular disease, and it describes the links between ocula…
Nature Reviews Immunology, Published online: 23 August 2024; doi:10.1038/s41577-024-01082-wOrganoids generated from individuals with coeliac disease identify a role for IL-7 in disease pathogenesis.
Nature Reviews Immunology, Published online: 23 August 2024; doi:10.1038/s41577-024-01086-6Kloosterman, Erbani et al. describe a lipid-mediated, metabolic crosstalk between tumour-associated macrophages and glioblastoma cells that supp…
Nature Reviews Immunology, Published online: 09 August 2024; doi:10.1038/s41577-024-01067-9This Review discusses the different mechanisms of antibody-dependent enhancement (ADE) of infectious disease, including how antibodies can incre…
Nature Reviews Immunology, Published online: 08 August 2024; doi:10.1038/s41577-024-01078-6Thierry, Baudon et al. show that non-classical monocytes are nurtured by endothelial cell expression of CSF1 throughout the whole vascular tree.
Nature Reviews Immunology, Published online: 29 July 2024; doi:10.1038/s41577-024-01069-7In this Tools of the Trade article, Camilla Engblom and colleagues describe their elegant technique ‘Spatial VDJ’ to detect and map antigen recept…
Nature Reviews Immunology, Published online: 29 July 2024; doi:10.1038/s41577-024-01074-wNeuroinflammation in response to infection or chronic disease can cause non-neural symptoms such as fatigue and muscle pain. Yang et al. show that…
Nature Reviews Immunology, Published online: 29 July 2024; doi:10.1038/s41577-024-01072-yTransient depletion of the gut microbiome by antibiotics in early life reduces systemic levels of the metabolite indole-3-propionic acid, which ca…
Nature Reviews Immunology, Published online: 25 July 2024; doi:10.1038/s41577-024-01061-1This Review covers recent advances in our understanding of CD28 co-stimulation of T cells and discusses an emerging paradigm that positions CD28 a…
Nature Reviews Immunology, Published online: 24 July 2024; doi:10.1038/s41577-024-01071-zThe pyroptotic secretome can be beneficial in promoting tissue repair.
Nature Reviews Immunology, Published online: 15 July 2024; doi:10.1038/s41577-024-01057-xHere, Raffatellu and co-workers discuss our growing understanding of how primary bile acids (which are cholesterol-derived molecules synthesized i…
Nature Reviews Immunology, Published online: 12 July 2024; doi:10.1038/s41577-024-01066-wIn this Comment article, organizers of the International School of Immunotherapy (Immunoschool) reflect on the experience gained from the past ten…
Nature Reviews Immunology, Published online: 12 July 2024; doi:10.1038/s41577-024-01068-8Two papers in Nature Immunology provide a comprehensive atlas of human natural killer cells in health and in different types of cancer.
Nature Reviews Immunology, Published online: 12 July 2024; doi:10.1038/s41577-024-01065-xAge-associated defects in dendritic cells can be corrected by hyperactivating adjuvants containing an oxidized phospholipid to induce effective an…
Nature Reviews Immunology, Published online: 09 July 2024; doi:10.1038/s41577-024-01048-yThis Review by Arnold and Munitz discusses the diverse roles of eosinophils in the settings of tissue homeostasis, infection, allergy and cancer. …
Nature Reviews Immunology, Published online: 05 July 2024; doi:10.1038/s41577-024-01062-0In this Viewpoint, Nature Reviews Immunology invites eight experts in the field to share their thoughts on the key questions and challenges in MDS…
Nature Reviews Immunology, Published online: 04 July 2024; doi:10.1038/s41577-024-01058-wA preprint by Ngo et al. reports a new mouse model for the constitutive depletion of pDCs, showing that pDCs are dispensable for antiviral immunity.
Nature Reviews Immunology, Published online: 04 July 2024; doi:10.1038/s41577-024-01063-zAhmed et al. report that IL-23-dependent CTLA4 expression by ILC3s restrains T cell-mediated inflammation in the intestine.
Nature Reviews Immunology, Published online: 04 July 2024; doi:10.1038/s41577-024-01059-9A preprint by Stevens et al. establishes a novel mechanism by which the gut micobiota provides protection against neonatal respiratory tract infec…
Nature Reviews Immunology, Published online: 02 July 2024; doi:10.1038/s41577-024-01060-2A preprint by Kaltenbach et al. shows a role for cytoskeletal control mechanisms in contributing to the tissue maintenance of mast cells.
Nature Reviews Immunology, Published online: 24 June 2024; doi:10.1038/s41577-024-01043-3Here, the authors review the single-cell sequencing studies of rheumatic and allergic diseases, providing insight into disease pathogenesis, bioma…
Nature Reviews Immunology, Published online: 11 June 2024; doi:10.1038/s41577-024-01054-0A study by Nakayama et al. shows that heart failure causes epigenetic changes in haematopoietic stem cells that predispose to further heart diseas…
Nature Reviews Immunology, Published online: 11 June 2024; doi:10.1038/s41577-024-01056-yAn adoptive cellular therapy based on γδ T cells, which were engineered to secrete a tumour-targeting opsonin as well as an IL-15 superagonist, co…
Nature Reviews Immunology, Published online: 11 June 2024; doi:10.1038/s41577-024-01041-5Malaria remains a devastating human disease. Although malaria vaccines are available, their limited efficacy and protective duration are problemat…
Nature Reviews Immunology, Published online: 10 June 2024; doi:10.1038/s41577-024-01055-zCAR T cell therapy alleviates type 2 airway inflammation in mouse models of asthma.
Nature Reviews Immunology, Published online: 03 June 2024; doi:10.1038/s41577-024-01049-xThis Comment discusses the potential effects of ultra-processed foods (UPFs) on the immune system independently of obesity, by which UPFs might dy…
Nature Reviews Immunology, Published online: 03 June 2024; doi:10.1038/s41577-024-01040-6This Review provides a guide to the memory cells of the adaptive immune system, comprising memory T cells, memory B cells and plasma cells; it cov…
Nature Reviews Immunology, Published online: 03 June 2024; doi:10.1038/s41577-024-01035-3Recent clinical studies show that chimeric antigen receptor (CAR) T cells, best known for treating B cell malignancies, can be used to treat patie…
Nature Reviews Immunology, Published online: 31 May 2024; doi:10.1038/s41577-024-01053-1CD8+ T cells become exhausted when exposed to the mechanical forces of stiff solid tumours, owing to signalling through the transcription factor OSR2.
Nature Reviews Immunology, Published online: 28 May 2024; doi:10.1038/s41577-024-01051-3Author Correction: Cancer cell metabolism and antitumour immunity
Nature Reviews Immunology, Published online: 24 May 2024; doi:10.1038/s41577-024-01052-2Two papers in Immunity report the effects of acetylcholine secretion by intestinal tuft cells on epithelial cells and helminths that contribute to …
Nature Reviews Immunology, Published online: 24 May 2024; doi:10.1038/s41577-024-01050-4A preprint by Ben-Chetrit et al. investigates the molecular and cellular mechanisms that regulate macrophage heterogeneity in solid breast cancer t…
Nature Reviews Immunology, Published online: 23 May 2024; doi:10.1038/s41577-024-01047-zIn this Tools of the Trade article, Sandra Nakandakari-Higa (of the Gabriel Victora lab) describes the latest version of their LIPSTIC technique fo…
Nature Reviews Immunology, Published online: 08 May 2024; doi:10.1038/s41577-024-01042-4Commensal bacteria induce liver macrophages that protect the tissue against inflammation.
Nature Reviews Immunology, Published online: 07 May 2024; doi:10.1038/s41577-024-01025-5This Review from Comerford and McColl discusses recent advances that have been made in understanding the biology of the atypical chemokine receptor…
Nature Reviews Immunology, Published online: 02 May 2024; doi:10.1038/s41577-024-01029-1An optimal immune response to influenza virus strikes a balance between protective antiviral immune mechanisms and detrimental immunopathology. Her…
Nature Reviews Immunology, Published online: 02 May 2024; doi:10.1038/s41577-024-01030-8Compared with many other vaccines, current vaccines against influenza provide only limited protection. Here, the authors describe the challenges an…
Nature Reviews Immunology, Published online: 29 April 2024; doi:10.1038/s41577-024-01027-3Here, Rongbin Zhou and colleagues review the different types of damage-associated molecular pattern (DAMP) that trigger sterile inflammation via …
Nature Reviews Immunology, Published online: 26 April 2024; doi:10.1038/s41577-024-01039-zWei et al. report a role for membrane perforation mediated by gasdermin D pores in disruption of the blood–brain barrier.
Nature Reviews Immunology, Published online: 26 April 2024; doi:10.1038/s41577-024-01038-0A preprint by Yi et al. shows a role for the FAS signalling pathway in controlling the persistence of CAR-modified lymphocytes.
Nature Reviews Immunology, Published online: 24 April 2024; doi:10.1038/s41577-024-01022-8Genome editing approaches can be used to confer immune-evasive properties to allogeneic cellular immunotherapies, with the aim of achieving persi…
Nature Reviews Immunology, Published online: 24 April 2024; doi:10.1038/s41577-024-01036-2Sex hormones in male mice negatively regulate type 2 innate lymphoid cells in the skin, impairing the induction and activation of dendritic cells…
Nature Reviews Immunology, Published online: 24 April 2024; doi:10.1038/s41577-024-01037-1Adrian Liston, professor of pathology at the University of Cambridge, UK, has published several illustrated children’s books on the topic of vacc…
Nature Reviews Immunology, Published online: 22 April 2024; doi:10.1038/s41577-024-01026-4This Review discusses the mechanisms by which common alterations of cancer cell metabolism interfere with immune functions to promote immunoevasi…
Nature Reviews Immunology, Published online: 09 April 2024; doi:10.1038/s41577-024-01031-7Depletion of myeloid-biased haematopoietic stem cells can mitigate age-associated immune dysfunction.
