- Thymus engraftment and developmental progression of adoptively transferred progenitor T cells are affected by host conditioningby inmunoadminJ Immunol. 2026 Apr 15;215(4):vkag086. doi: 10.1093/jimmun/vkag086. ABSTRACT Hematopoietic stem cell transplantation as treatment for patients with leukemia relies on chemotherapy and/or irradiation-based conditioning regimens to prevent graft rejection and cancer relapse. Despite advances in radiotherapy, total body irradiation for myeloablative conditioning is associated with dose and temporal heterogeneity, and how these variables impact thymus … Read more
- Calibrating T cell responsiveness through interactions with selfby Judith N. MandlNature Reviews Immunology, Published online: 08 May 2026; doi:10.1038/s41577-026-01305-2T cells integrate signals from self-ligands not only during thymic development but also as they circulate through secondary lymphoid organs. These …
- VISTA neutralization by immunization reprograms immunosuppression and augments vaccine efficacy in renal carcinomaby inmunoadminBackground Renal carcinoma remains a highly lethal malignancy, and tumor vaccine efficacy is frequently hampered by a profoundly immunosuppressive tumor microenvironment. V-domain Ig suppressor of T-cell activation (VISTA), an inhibitory immune checkp…
- Phase 1 multicenter study of the NKG2A targeting antibody S095029 as a single agent and in combination with anti-PD-1 in patients with advanced malignanciesby inmunoadminBackground NKG2A is a C-type lectin that heterodimerizes with CD94 creating an inhibitory immunoreceptor. S095029 is a fully human monoclonal IgG1 anti-NKG2A antibody with attenuated Fc-effector functions that specifically binds the NKG2A/CD94 heterod…
- LGALS9 blockade augments vaccine-induced immune responses against prostate cancerby Lu, B., Liu, N., Zhao, W., Chen, H., Shao, Y., Lu, H., Liu, S., Yang, J., Zheng, Y., Ding, J., Chai, D., Mao, L.Background Prostate-specific membrane antigen (PSMA)-based vaccination represents a promising immunotherapeutic strategy for prostate cancer; however, its efficacy remains constrained by tumor-induced immune evasion and insufficient activation of anti…