Journal of Leukocyte Biology

Nature Reviews Immunology, Published online: 23 June 2026; doi:10.1038/s41577-026-01325-yTwentieth-century immunology was shaped by questions of recognition, diversity, response and tolerance. The next era may be defined by a different…

Trends Immunol. 2026 Jun 23:S1471-4906(26)00138-9. doi: 10.1016/j.it.2026.06.001. Online ahead of print. ABSTRACT Growing evidence indicates that gut microbiota-derived metabolites are key regulators of immunometabolism in inflammatory bowel disease (IBD). Intestinal epithelial cells and immune cells exhibit profound metabolic alterations in IBD. Microbial metabolites act as intermediates in host-microbe communication, reshaping mitochondrial functions and cellular metabolic … Read more

Curr Opin Immunol. 2026 Jun 22;101:102805. doi: 10.1016/j.coi.2026.102805. Online ahead of print. ABSTRACT Solid‑phase assays for the detection of antiphospholipid antibodies (aPL) are central to the laboratory evaluation of antiphospholipid syndrome (APS). Growing insights into the molecular immunology underlying these assays challenge traditional interpretations. It is now evident that the antigenic drivers are phospholipids (PL)‑binding … Read more

Mucosal Immunol. 2026 Jun 22:100365. doi: 10.1016/j.mucimm.2026.100365. Online ahead of print. ABSTRACT Adaptive immune responses, including B and T cell responses, play important roles in establishing and maintaining the mutualistic relationship between the host and intestinal microbiota. Host-microbiota mutualism is disrupted in various immune-mediated inflammatory diseases, including Crohn’s disease (CD). Aberrant inflammatory memory CD4+ T … Read more

The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a key component of the innate immune system, responding to the presence of DNA within cells to trigger an inflammatory response. A growing body of research s…