- TCR-based therapy directed against kallikrein-related peptidase 4 is safe and effective against prostate cancerby inmunoadminCancer Immunol Res. 2025 May 19. doi: 10.1158/2326-6066.CIR-24-0119. Online ahead of print. ABSTRACT The efficacy of most immunotherapies for prostate cancer is limited by poor tumor immunogenicity, evidenced by minimal T-cell infiltration. Treatment with T cells engineered to express T-cell receptors (TCR) targeting prostate-specific antigens offers a potential solution by bypassing endogenous T-cell repertoire limitations. … Read more
- Combination Therapy Approaches to Enhance the Efficacy of ERV-Targeting Vaccines in Cancerby inmunoadminCancer Immunol Res. 2025 May 19:OF1-OF12. doi: 10.1158/2326-6066.CIR-24-1192. Online ahead of print. ABSTRACT Endogenous retroviruses (ERV) are the genetic remnants of retroviruses in which proviral sequences integrated into germline cells of our ancestors. Although the vast majority of ERV sequences have accumulated mutations over the course of human evolution, some still contain open reading frames … Read more
- Targeting Lp-PLA2 inhibits profibrotic monocyte-derived macrophages in silicosis through restoring cardiolipin-mediated mitophagyby Shifeng LiCellular & Molecular Immunology, Published online: 19 May 2025; doi:10.1038/s41423-025-01288-5Targeting Lp-PLA2 inhibits profibrotic monocyte-derived macrophages in silicosis through restoring cardiolipin-mediated mitophagy
- Notch-activated basophils support intestinal CD4+ T cell fate and function during helminth infection. Lauren M Webbby inmunoadminMucosal Immunol. 2025 May 16:S1933-0219(25)00051-0. doi: 10.1016/j.mucimm.2025.05.004. Online ahead of print. ABSTRACT Helminth infections affect billions of people worldwide and cause substantial morbidity. Intestinal helminth infection provokes Type 2 inflammation orchestrated by CD4+ T helper type 2 (Th2) cells. Th2 cells cooperate with group 2 innate lymphoid cells (ILC2s) to produce interleukin (IL)-4 and IL-13 … Read more
- A role of CD20+ T cells in early multiple sclerosisby Marina Rode von EssenRelapsing-remitting multiple sclerosis (RRMS) is a chronic immune-mediated disease of the central nervous system (CNS) characterized by episodic relapses of neurological symptoms. Early diagnosis and treatment of patients is key to prevent relapses and…